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      <content:encoded><![CDATA[<div><p style="color: #4aa564;">Environ Heal ...

Source: http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ

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<link>https://pubmed.ncbi.nlm.nih.gov/rss-feed/?feed_id=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&utm_source=Feedvalidator</link>
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<pubDate>Sat, 18 May 2024 06:00:00 -0400</pubDate>
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<title>A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38762486/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>BACKGROUND: The primary objective of this randomized controlled trial (RCT) is to establish the effectiveness of time-restricted eating (TRE) compared with the Mediterranean diet for people with bipolar disorder (BD) who have symptoms of sleep disorders or circadian rhythm sleep-wake disruption. This work builds on the growing evidence that TRE has benefits for improving circadian rhythms. TRE and Mediterranean diet guidance will be offered remotely using self-help materials and an app, with...</description>
<content:encoded><![CDATA[<div>BMC Psychiatry. 2024 May 18;24(1):374. doi: 10.1186/s12888-024-05790-4.ABSTRACTBACKGROUND: The primary objective of this randomized controlled trial (RCT) is to establish the effectiveness of time-restricted eating (TRE) compared with the Mediterranean diet for people with bipolar disorder (BD) who have symptoms of sleep disorders or circadian rhythm sleep-wake disruption. This work builds on the growing evidence that TRE has benefits for improving circadian rhythms. TRE and Mediterranean diet guidance will be offered remotely using self-help materials and an app, with coaching support.METHODS: This study is an international RCT to compare the effectiveness of TRE and the Mediterranean diet. Three hundred participants will be recruited primarily via social media. Main inclusion criteria are: receiving treatment for a diagnosis of BD I or II (confirmed via DIAMOND structured diagnostic interview), endorsement of sleep or circadian problems, self-reported eating window of ≥ 12 h, and no current mood episode, acute suicidality, eating disorder, psychosis, alcohol or substance use disorder, or other health conditions that would interfere with or limit the safety of following the dietary guidance. Participants will be asked to complete baseline daily food logging for two weeks and then will be randomly allocated to follow TRE or the Mediterranean diet for 8 weeks, during which time, they will continue to complete daily food logging. Intervention content will be delivered via an app. Symptom severity interviews will be conducted at baseline; mid-intervention (4 weeks after the intervention begins); end of intervention; and at 6, 9, and 15 months post-baseline by phone or videoconference. Self-rated symptom severity and quality of life data will be gathered at those timepoints, as well as at 16 weeks post baseline. To provide a more refined index of whether TRE successfully decreases emotional lability and improves sleep, participants will be asked to complete a sleep diary (core CSD) each morning and complete six mood assessments per day for eight days at baseline and again at mid-intervention.DISCUSSION: The planned research will provide novel and important information on whether TRE is more beneficial than the Mediterranean diet for reducing mood symptoms and improving quality of life in individuals with BD who also experience sleep or circadian problems.TRIAL REGISTRATION: ClinicalTrials.gov ID NCT06188754.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38762486/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38762486</a> | DOI:<a href=https://doi.org/10.1186/s12888-024-05790-4>10.1186/s12888-024-05790-4</a></div>]]></content:encoded>
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<pubDate>Sat, 18 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Sheri L Johnson</dc:creator>
<dc:creator>Greg Murray</dc:creator>
<dc:creator>Lance J Kriegsfeld</dc:creator>
<dc:creator>Emily N C Manoogian</dc:creator>
<dc:creator>Liam Mason</dc:creator>
<dc:creator>J D Allen</dc:creator>
<dc:creator>Michael Berk</dc:creator>
<dc:creator>Satchidanda Panda</dc:creator>
<dc:creator>Nandini A Rajgopal</dc:creator>
<dc:creator>Jake C Gibson</dc:creator>
<dc:creator>Keanan J Joyner</dc:creator>
<dc:creator>Robert Villanueva</dc:creator>
<dc:creator>Erin E Michalak</dc:creator>
<dc:date>2024-05-18</dc:date>
<dc:source>BMC psychiatry</dc:source>
<dc:title>A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder</dc:title>
<dc:identifier>pmid:38762486</dc:identifier>
<dc:identifier>doi:10.1186/s12888-024-05790-4</dc:identifier>
</item>
<item>
<title>Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38761895/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: SOAT1-mediated esterification may underlie cholesterol crystals associated with MASH by concentrating it in lipid droplets. These findings imply that inhibiting hepatocyte SOAT1 may be able to alleviate cholesterol associated MASH. Moreover, that either a lipid droplet localized cholesteryl ester hydrolase is required for cholesterol crystal formation, or the crystals are composed of cholesteryl ester.</description>
<content:encoded><![CDATA[<div>Biochim Biophys Acta Mol Cell Biol Lipids. 2024 May 16:159512. doi: 10.1016/j.bbalip.2024.159512. Online ahead of print.ABSTRACTOBJECTIVE: Excess cholesterol storage can induce the formation of cholesterol crystals in hepatocyte lipid droplets. Such crystals distinguish metabolic dysfunction associated steatohepatitis (MASH) from simple steatosis and may underlie its pathogenesis by causing cell damage that triggers liver inflammation. The mechanism linking cholesterol excess to its crystallization in lipid droplets is unclear. As cholesteryl esters localize to and accumulate in lipid droplets more readily than unesterified free cholesterol, we investigated whether cholesterol esterification by sterol O-acyltransferase (SOAT), also known as acyl co-A cholesterol acyltransferase (ACAT), is required for hepatocyte lipid droplet crystal formation.METHOD: Cholesterol crystals were measured in cholesterol loaded Hep3B hepatocytes, RAW264.7 macrophages, and mouse liver using polarizing light microscopy. We examined the effect of blocking SOAT activity on crystal formation and compared these results to features of cholesterol metabolism and the progression to intracellular crystal deposits.RESULTS: Cholesterol loading of Hep3B cells caused robust levels of lipid droplet localized crystal formation in a dose- and time-dependent manner. Co-treatment with SOAT inhibitors and genetic ablation of SOAT1 blocked crystal formation. SOAT inhibitor also blocked crystal formation in low density lipoprotein (LDL) treated Hep3B cells, acetylated LDL treated RAW 264.7 macrophages, and in the liver of mice genetically predisposed to hepatic cholesterol overload and in mice with cholesterol enriched diet-induced MASH.CONCLUSION: SOAT1-mediated esterification may underlie cholesterol crystals associated with MASH by concentrating it in lipid droplets. These findings imply that inhibiting hepatocyte SOAT1 may be able to alleviate cholesterol associated MASH. Moreover, that either a lipid droplet localized cholesteryl ester hydrolase is required for cholesterol crystal formation, or the crystals are composed of cholesteryl ester.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38761895/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38761895</a> | DOI:<a href=https://doi.org/10.1016/j.bbalip.2024.159512>10.1016/j.bbalip.2024.159512</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38761895</guid>
<pubDate>Sat, 18 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jordan A Bairos</dc:creator>
<dc:creator>Uche Njoku</dc:creator>
<dc:creator>Maria Zafar</dc:creator>
<dc:creator>May G Akl</dc:creator>
<dc:creator>Lei Li</dc:creator>
<dc:creator>Gunes Parlakgul</dc:creator>
<dc:creator>Ana Paula Arruda</dc:creator>
<dc:creator>Scott B Widenmaier</dc:creator>
<dc:date>2024-05-18</dc:date>
<dc:source>Biochimica et biophysica acta. Molecular and cell biology of lipids</dc:source>
<dc:title>Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets</dc:title>
<dc:identifier>pmid:38761895</dc:identifier>
<dc:identifier>doi:10.1016/j.bbalip.2024.159512</dc:identifier>
</item>
<item>
<title>Prenatal maternal Inflammation, childhood cognition and adolescent depressive symptoms</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38761818/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: Lower childhood cognitive performance, such as that indicated by a lower PPVT score, represents a potential mechanism through which prenatal maternal inflammation contributes to adolescent depression risk in offspring.</description>
<content:encoded><![CDATA[<div>Brain Behav Immun. 2024 May 16:S0889-1591(24)00400-8. doi: 10.1016/j.bbi.2024.05.012. Online ahead of print.ABSTRACTBACKGROUND: Accumulating evidence indicates that higher prenatal maternal inflammation is associated with increased depression risk in adolescent and adult-aged offspring. Prenatal maternal inflammation (PNMI) may increase the likelihood for offspring to have lower cognitive performance, which, in turn, may heighten risk for depression onset. Therefore, this study explored the potential mediating role of childhood cognitive performance in the relationship between PNMI and adolescent depressive symptoms in offspring.METHODS: Participants included 696 mother-offspring dyads from the Child Health and Development Studies (CHDS) cohort. Biomarkers of maternal inflammation [interleukin (IL)-6, IL-8, IL-1 receptor antagonist (IL-1RA) and soluble TNF receptor-II (sTNF-RII)] were assayed from first (T1) and second trimester (T2) sera. Childhood (ages 9-11) cognitive performance was assessed via standardized Peabody Picture Vocabulary Test (PPVT), a measure of receptive vocabulary correlated with general intelligence. Adolescent (ages 15-17) depressive symptoms were assessed via self-report.RESULTS: There were no significant associations between T1 biomarkers and childhood PPVT or adolescent depressive symptoms. Higher T2 IL1-RA was directly associated with lower childhood PPVT (b = -0.21, SE = 0.08, t = -2.55, p = 0.01), but not with adolescent depressive symptoms. T2 IL-6 was not directly associated with childhood PPVT, but higher T2 IL-6 was directly associated at borderline significance with greater depressive symptoms in adolescence (b = 0.05, SE = 0.03, t = 1.96, p = 0.05). Lower childhood PPVT predicted significantly higher adolescent depressive symptoms (b = -0.07, SE = 0.02, t = -2.99, p < 0.01). There was a significant indirect effect of T2 IL-1RA on adolescent depressive symptoms via childhood PPVT (b = 0.03, 95 % CI = 0.002-0.03) indicating a partially mediated effect. No significant associations were found with T2 sTNF-RII nor IL-8.CONCLUSIONS: Lower childhood cognitive performance, such as that indicated by a lower PPVT score, represents a potential mechanism through which prenatal maternal inflammation contributes to adolescent depression risk in offspring.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38761818/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38761818</a> | DOI:<a href=https://doi.org/10.1016/j.bbi.2024.05.012>10.1016/j.bbi.2024.05.012</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38761818</guid>
<pubDate>Sat, 18 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Madeline R Pike</dc:creator>
<dc:creator>Emily Lipner</dc:creator>
<dc:creator>Kathleen J O'Brien</dc:creator>
<dc:creator>Elizabeth C Breen</dc:creator>
<dc:creator>Barbara A Cohn</dc:creator>
<dc:creator>Piera M Cirillo</dc:creator>
<dc:creator>Nickilou Y Krigbaum</dc:creator>
<dc:creator>Ann M Kring</dc:creator>
<dc:creator>Thomas M Olino</dc:creator>
<dc:creator>Lauren B Alloy</dc:creator>
<dc:creator>Lauren M Ellman</dc:creator>
<dc:date>2024-05-18</dc:date>
<dc:source>Brain, behavior, and immunity</dc:source>
<dc:title>Prenatal maternal Inflammation, childhood cognition and adolescent depressive symptoms</dc:title>
<dc:identifier>pmid:38761818</dc:identifier>
<dc:identifier>doi:10.1016/j.bbi.2024.05.012</dc:identifier>
</item>
<item>
<title>Conspicuity of staircase configuration: Effects of markings and contrast</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38761017/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: Adding marking patterns such as high-contrast transverse stripes to stairs may help enhance the visibility of the stairs and judgements of staircase geometry. This might be particularly useful for people with visual impairment or normally sighted individuals under compromised environmental conditions.</description>
<content:encoded><![CDATA[<div>Ophthalmic Physiol Opt. 2024 May 18. doi: 10.1111/opo.13333. Online ahead of print.ABSTRACTPURPOSE: To be able to walk safely up or down a staircase, we must be able to judge the configuration and slope of the staircase and our viewing position. Adding markings to the stairs might help form correct perceptions of the staircase geometry. In this study, we examined how visual judgements about staircase configuration are affected by different marking patterns.METHODS: Fifteen normally sighted young participants viewed computer-generated images of staircases as seen from the top landing of the stairs. Marking patterns included contrasting baseboard, transverse edge-stripes, longitudinal side-stripes, longitudinal stripes, diamond patterns, longitudinal stripes extended to landing and diamond patterns extended to landing. For comparison, we included the no-marking condition as a control. We tested several contrast levels of marking patterns (3.2%-50%), pitch lines of the staircases (shallow/medium/steep) and viewing positions (left/centre/right). The effect of the overall shape cue of the staircase on participants' performance was also evaluated. We measured participants' accuracies in judging whether the staircase was shallow, medium or steep, and whether the viewing position was located to the left, centre or right.RESULTS: Transverse edge-stripes markings yielded fewer underestimations of slope (9% [transverse] vs. 18% [others]) when compared with other markers. The presence of an overall shape cue helped both slope (67% [presence] vs. 51% [absence]) and viewing position judgements (79% [presence] vs. 62% [absence]). When the overall shape cue was present, only the transverse edge-stripes markings yielded a significant improvement in performance (compared with no-marking condition). When the cue was absent, performance was significantly better with markings with high and moderate contrasts.CONCLUSIONS: Adding marking patterns such as high-contrast transverse stripes to stairs may help enhance the visibility of the stairs and judgements of staircase geometry. This might be particularly useful for people with visual impairment or normally sighted individuals under compromised environmental conditions.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38761017/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38761017</a> | DOI:<a href=https://doi.org/10.1111/opo.13333>10.1111/opo.13333</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38761017</guid>
<pubDate>Sat, 18 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Deyue Yu</dc:creator>
<dc:creator>Susana T L Chung</dc:creator>
<dc:creator>Ian L Bailey</dc:creator>
<dc:date>2024-05-18</dc:date>
<dc:source>Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)</dc:source>
<dc:title>Conspicuity of staircase configuration: Effects of markings and contrast</dc:title>
<dc:identifier>pmid:38761017</dc:identifier>
<dc:identifier>doi:10.1111/opo.13333</dc:identifier>
</item>
<item>
<title>Beclin-mediated Autophagy Drives Dorsal Longitudinal Flight Muscle Histolysis in the Variable Field Cricket, Gryllus lineaticeps</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38760886/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Flight muscle histolysis is a widespread strategy used by insects to break down functional flight muscle and modulate the energetic costs associated with flight muscle use and maintenance. The variable field cricket, Gryllus lineaticeps, undergoes histolysis during their transition between dispersal flight and reproduction. Despite the importance of histolysis on insect reproduction and fitness, the molecular mechanisms driving this flight muscle breakdown are not well understood. Here, we show...</description>
<content:encoded><![CDATA[<div>Integr Comp Biol. 2024 May 17:icae042. doi: 10.1093/icb/icae042. Online ahead of print.ABSTRACTFlight muscle histolysis is a widespread strategy used by insects to break down functional flight muscle and modulate the energetic costs associated with flight muscle use and maintenance. The variable field cricket, Gryllus lineaticeps, undergoes histolysis during their transition between dispersal flight and reproduction. Despite the importance of histolysis on insect reproduction and fitness, the molecular mechanisms driving this flight muscle breakdown are not well understood. Here, we show that beclin-mediated autophagy, a conserved lysosomal-dependent degradation process, drives breakdown of dorsal longitudinal flight muscle in female flight capable G. lineaticeps. We found that female G. lineaticeps activate autophagy in their dorsal longitudinal flight muscle (DLM), but to a greater extent than the neighboring dorsoventral flight muscle (DVM) during histolysis. RNA interference knockdown of beclin, a gene which encodes a critical autophagy initiation protein, delayed DLM histolysis, but did not affect DVM histolysis. This suggests that crickets selectively activate autophagy to break down the DLMs, while maintaining DVM function for other fitness-relevant activities such as walking. Overall, we confirmed that autophagy is a critical pathway used to remodel flight muscle cells during flight muscle histolysis, providing novel insights into the mechanisms underlying a major life history transition between dispersal and reproduction.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38760886/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38760886</a> | DOI:<a href=https://doi.org/10.1093/icb/icae042>10.1093/icb/icae042</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38760886</guid>
<pubDate>Sat, 18 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Tomás Diaz</dc:creator>
<dc:creator>Lisa A Treidel</dc:creator>
<dc:creator>Michael A Menze</dc:creator>
<dc:creator>Caroline M Williams</dc:creator>
<dc:creator>Jacqueline E Lebenzon</dc:creator>
<dc:date>2024-05-18</dc:date>
<dc:source>Integrative and comparative biology</dc:source>
<dc:title>Beclin-mediated Autophagy Drives Dorsal Longitudinal Flight Muscle Histolysis in the Variable Field Cricket, Gryllus lineaticeps</dc:title>
<dc:identifier>pmid:38760886</dc:identifier>
<dc:identifier>doi:10.1093/icb/icae042</dc:identifier>
</item>
<item>
<title>Bidirectional epigenetic editing reveals hierarchies in gene regulation</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38760566/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CRISPR perturbation methods are limited in their ability to study non-coding elements and genetic interactions. In this study, we developed a system for bidirectional epigenetic editing, called CRISPRai, in which we apply activating (CRISPRa) and repressive (CRISPRi) perturbations to two loci simultaneously in the same cell. We developed CRISPRai Perturb-seq by coupling dual perturbation gRNA detection with single-cell RNA sequencing, enabling study of pooled perturbations in a mixed single-cell...</description>
<content:encoded><![CDATA[<div>Nat Biotechnol. 2024 May 17. doi: 10.1038/s41587-024-02213-3. Online ahead of print.ABSTRACTCRISPR perturbation methods are limited in their ability to study non-coding elements and genetic interactions. In this study, we developed a system for bidirectional epigenetic editing, called CRISPRai, in which we apply activating (CRISPRa) and repressive (CRISPRi) perturbations to two loci simultaneously in the same cell. We developed CRISPRai Perturb-seq by coupling dual perturbation gRNA detection with single-cell RNA sequencing, enabling study of pooled perturbations in a mixed single-cell population. We applied this platform to study the genetic interaction between two hematopoietic lineage transcription factors, SPI1 and GATA1, and discovered novel characteristics of their co-regulation on downstream target genes, including differences in SPI1 and GATA1 occupancy at genes that are regulated through different modes. We also studied the regulatory landscape of IL2 (interleukin-2) in Jurkat T cells, primary T cells and chimeric antigen receptor (CAR) T cells and elucidated mechanisms of enhancer-mediated IL2 gene regulation. CRISPRai facilitates investigation of context-specific genetic interactions, provides new insights into gene regulation and will enable exploration of non-coding disease-associated variants.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38760566/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38760566</a> | DOI:<a href=https://doi.org/10.1038/s41587-024-02213-3>10.1038/s41587-024-02213-3</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38760566</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Naomi M Pacalin</dc:creator>
<dc:creator>Zachary Steinhart</dc:creator>
<dc:creator>Quanming Shi</dc:creator>
<dc:creator>Julia A Belk</dc:creator>
<dc:creator>Dmytro Dorovskyi</dc:creator>
<dc:creator>Katerina Kraft</dc:creator>
<dc:creator>Kevin R Parker</dc:creator>
<dc:creator>Brian R Shy</dc:creator>
<dc:creator>Alexander Marson</dc:creator>
<dc:creator>Howard Y Chang</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Nature biotechnology</dc:source>
<dc:title>Bidirectional epigenetic editing reveals hierarchies in gene regulation</dc:title>
<dc:identifier>pmid:38760566</dc:identifier>
<dc:identifier>doi:10.1038/s41587-024-02213-3</dc:identifier>
</item>
<item>
<title>Addressing Fecal Contamination in Rural Kenyan Households: The Roles of Environmental Interventions and Animal Ownership</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38760010/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Combined water, sanitation, and handwashing (WSH) interventions could reduce fecal contamination along more transmission pathways than single interventions alone. We measured Escherichia coli levels in 3909 drinking water samples, 2691 child hand rinses, and 2422 toy ball rinses collected from households enrolled in a 2-year cluster-randomized controlled trial evaluating single and combined WSH interventions. Water treatment with chlorine reduced E. coli in drinking water. A combined WSH...</description>
<content:encoded><![CDATA[<div>Environ Sci Technol. 2024 May 17. doi: 10.1021/acs.est.3c09419. Online ahead of print.ABSTRACTCombined water, sanitation, and handwashing (WSH) interventions could reduce fecal contamination along more transmission pathways than single interventions alone. We measured Escherichia coli levels in 3909 drinking water samples, 2691 child hand rinses, and 2422 toy ball rinses collected from households enrolled in a 2-year cluster-randomized controlled trial evaluating single and combined WSH interventions. Water treatment with chlorine reduced E. coli in drinking water. A combined WSH intervention improved water quality by the same magnitude but did not affect E. coli levels on hands or toys. One potential explanation for the limited impact of the sanitation intervention (upgraded latrines) is failure to address dog and livestock fecal contamination. Small ruminant (goat or sheep) ownership was associated with increased E. coli levels in stored water and on child hands. Cattle and poultry ownership was protective against child stunting, and domesticated animal ownership was not associated with child diarrhea. Our findings do not support restricting household animal ownership to prevent child diarrheal disease or stunting but do support calls for WSH infrastructure that can more effectively reduce household fecal contamination.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38760010/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38760010</a> | DOI:<a href=https://doi.org/10.1021/acs.est.3c09419>10.1021/acs.est.3c09419</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38760010</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jenna M Swarthout</dc:creator>
<dc:creator>Maryanne Mureithi</dc:creator>
<dc:creator>John Mboya</dc:creator>
<dc:creator>Benjamin F Arnold</dc:creator>
<dc:creator>Marlene K Wolfe</dc:creator>
<dc:creator>Holly N Dentz</dc:creator>
<dc:creator>Audrie Lin</dc:creator>
<dc:creator>Charles D Arnold</dc:creator>
<dc:creator>Gouthami Rao</dc:creator>
<dc:creator>Christine P Stewart</dc:creator>
<dc:creator>Thomas Clasen</dc:creator>
<dc:creator>John M Colford</dc:creator>
<dc:creator>Clair Null</dc:creator>
<dc:creator>Amy J Pickering</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Environmental science & technology</dc:source>
<dc:title>Addressing Fecal Contamination in Rural Kenyan Households: The Roles of Environmental Interventions and Animal Ownership</dc:title>
<dc:identifier>pmid:38760010</dc:identifier>
<dc:identifier>doi:10.1021/acs.est.3c09419</dc:identifier>
</item>
<item>
<title>Association of body mass index with progression from binge-eating behavior into binge-eating disorder among adolescents in the United States: a prospective analysis of pooled data</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38759754/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The association between body mass index (BMI) and binge-eating disorder (BED) is well-established. However, data on the extent to which BMI is associated with progression from binge-eating behavior into BED among adolescents are limited, which was the aim of this investigation. Participants were 9,964 U.S. adolescents from the Adolescent Brain Cognitive Development (ABCD) Study, aged 9-13 at the time of study enrollment. A computerized parent-reported assessment was used to establish...</description>
<content:encoded><![CDATA[<div>Appetite. 2024 May 15:107419. doi: 10.1016/j.appet.2024.107419. Online ahead of print.ABSTRACTThe association between body mass index (BMI) and binge-eating disorder (BED) is well-established. However, data on the extent to which BMI is associated with progression from binge-eating behavior into BED among adolescents are limited, which was the aim of this investigation. Participants were 9,964 U.S. adolescents from the Adolescent Brain Cognitive Development (ABCD) Study, aged 9-13 at the time of study enrollment. A computerized parent-reported assessment was used to establish adolescents' binge-eating behaviors and BED. Cox proportional hazards models adjusting for sociodemographic covariates were used to examine prospective associations between BMI and likelihood of BED onset among a) adolescents with binge-eating behavior, and b) adolescents with no binge-eating behavior. Of 975 adolescents who met study criteria for binge-eating behavior, 89 (9.1%) subsequently met study criteria for BED. Of 8,989 adolescents with no binge-eating behavior, 82 (0.9%) subsequently met study criteria for BED. BMI percentile was significantly associated with the likelihood of BED onset in participants with [ adjusted HR =1.03 (1.00, 1.06)] and participants without [adjusted HR =1.05 (1.03, 1.07)] binge-eating behavior. Results were also significant when examining BMI as a dichotomous predictor (above and below 85th percentile) among those with [adjusted HR =2.60 (1.00, 6.68) and those without [adjusted HR =6.01 (3.90, 11.10)] binge-eating behavior. Overall, results indicate that elevated BMI is prospectively associated with a greater risk for BED onset among U.S. adolescents with or without binge-eating behavior. Adolescents with a higher BMI may benefit from screening for binge eating, and prevention/early intervention strategies to mitigate the risk for developing BED.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38759754/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38759754</a> | DOI:<a href=https://doi.org/10.1016/j.appet.2024.107419>10.1016/j.appet.2024.107419</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38759754</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Abubakr A A Al-Shoaibi</dc:creator>
<dc:creator>Jason M Lavender</dc:creator>
<dc:creator>Sean J Kim</dc:creator>
<dc:creator>Iris Yuefan Shao</dc:creator>
<dc:creator>Kyle T Ganson</dc:creator>
<dc:creator>Alexander Testa</dc:creator>
<dc:creator>Jinbo He</dc:creator>
<dc:creator>David V Glidden</dc:creator>
<dc:creator>Fiona C Baker</dc:creator>
<dc:creator>Jason M Nagata</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Appetite</dc:source>
<dc:title>Association of body mass index with progression from binge-eating behavior into binge-eating disorder among adolescents in the United States: a prospective analysis of pooled data</dc:title>
<dc:identifier>pmid:38759754</dc:identifier>
<dc:identifier>doi:10.1016/j.appet.2024.107419</dc:identifier>
</item>
<item>
<title>Evolutionary patterns of cat-like carnivorans unveil drivers of the sabertooth morphology</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38759651/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The sabertooth morphology stands as a classic case of convergence, manifesting recurrently across various vertebrate groups, prominently within two carnivorans clades: felids and nimravids. Nonetheless, the evolutionary mechanisms driving these recurring phenotypes remain insufficiently understood, lacking a robust phylogenetic and spatiotemporal framework. We reconstruct the tempo and mode of craniomandibular evolution of Felidae and Nimravidae and evaluate the strength of the dichotomy between...</description>
<content:encoded><![CDATA[<div>Curr Biol. 2024 May 13:S0960-9822(24)00529-3. doi: 10.1016/j.cub.2024.04.055. Online ahead of print.ABSTRACTThe sabertooth morphology stands as a classic case of convergence, manifesting recurrently across various vertebrate groups, prominently within two carnivorans clades: felids and nimravids. Nonetheless, the evolutionary mechanisms driving these recurring phenotypes remain insufficiently understood, lacking a robust phylogenetic and spatiotemporal framework. We reconstruct the tempo and mode of craniomandibular evolution of Felidae and Nimravidae and evaluate the strength of the dichotomy between conical and saber-toothed species, as well as within saber-toothed morphotypes. To do so, we investigate morphological variation, convergence, phenotypic integration, and evolutionary rates, employing a comprehensive dataset of nearly 200 3D models encompassing mandibles and crania from both extinct and extant feline-like carnivorans, spanning their entire evolutionary timeline. Our results reject the hypothesis of a distinctive sabertooth morphology, revealing instead a continuous spectrum of feline-like phenotypes in both the cranium and mandible, with sporadic instances of unequivocal convergence. Disparity peaked at the end of the Miocene and is usually higher in clades containing taxa with extreme sabertoothed adaptations. We show that taxa with saberteeth exhibit a lower degree of craniomandibular integration, allowing to exhibit a greater range of phenotypes. Those same groups usually show a burst of morphological evolutionary rate at the beginning of their evolutionary history. Consequently, we propose that a reduced degree of integration coupled with rapid evolutionary rates emerge as key components in the development of a sabertooth morphology in multiple clades.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38759651/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38759651</a> | DOI:<a href=https://doi.org/10.1016/j.cub.2024.04.055>10.1016/j.cub.2024.04.055</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38759651</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Narimane Chatar</dc:creator>
<dc:creator>Margot Michaud</dc:creator>
<dc:creator>Davide Tamagnini</dc:creator>
<dc:creator>Valentin Fischer</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Current biology : CB</dc:source>
<dc:title>Evolutionary patterns of cat-like carnivorans unveil drivers of the sabertooth morphology</dc:title>
<dc:identifier>pmid:38759651</dc:identifier>
<dc:identifier>doi:10.1016/j.cub.2024.04.055</dc:identifier>
</item>
<item>
<title>Tuber, or not tuber: Molecular and morphological basis of underground storage organ development</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38759482/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Underground storage organs occur in phylogenetically diverse plant taxa and arise from multiple tissue types including roots and stems. Thickening growth allows underground storage organs to accommodate carbohydrates and other nutrients and requires proliferation at various lateral meristems followed by cell expansion. The WOX-CLE module regulates thickening growth via the vascular cambium in several eudicot systems, but the molecular mechanisms of proliferation at other lateral meristems are...</description>
<content:encoded><![CDATA[<div>Curr Opin Plant Biol. 2024 May 16;80:102544. doi: 10.1016/j.pbi.2024.102544. Online ahead of print.ABSTRACTUnderground storage organs occur in phylogenetically diverse plant taxa and arise from multiple tissue types including roots and stems. Thickening growth allows underground storage organs to accommodate carbohydrates and other nutrients and requires proliferation at various lateral meristems followed by cell expansion. The WOX-CLE module regulates thickening growth via the vascular cambium in several eudicot systems, but the molecular mechanisms of proliferation at other lateral meristems are not well understood. In potato, onion, and other systems, members of the phosphatidylethanolamine-binding protein (PEBP) gene family induce underground storage organ development in response to photoperiod cues. While molecular mechanisms of tuber development in potato are well understood, we lack detailed mechanistic knowledge for the extensive morphological and taxonomic diversity of underground storage organs in plants.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38759482/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38759482</a> | DOI:<a href=https://doi.org/10.1016/j.pbi.2024.102544>10.1016/j.pbi.2024.102544</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38759482</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Madison L Plunkert</dc:creator>
<dc:creator>Jesús Martínez-Gómez</dc:creator>
<dc:creator>Yesenia Madrigal</dc:creator>
<dc:creator>Adriana I Hernández</dc:creator>
<dc:creator>Carrie M Tribble</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Current opinion in plant biology</dc:source>
<dc:title>Tuber, or not tuber: Molecular and morphological basis of underground storage organ development</dc:title>
<dc:identifier>pmid:38759482</dc:identifier>
<dc:identifier>doi:10.1016/j.pbi.2024.102544</dc:identifier>
</item>
<item>
<title>Allysine-Targeted Molecular MRI Enables Early Prediction of Chemotherapy Response in Pancreatic Cancer</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38759082/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Neoadjuvant therapy (NAT) is routinely used in pancreatic ductal adenocarcinoma (PDAC), but not all tumors respond to this treatment. Current clinical imaging techniques are not able to precisely evaluate and predict the response to neoadjuvant therapies over several weeks. A strong fibrotic reaction is a hallmark of a positive response, and during fibrogenesis allysine residues are formed on collagen proteins by the action of lysyl oxidases (LOX). Here we report the application of an...</description>
<content:encoded><![CDATA[<div>Cancer Res. 2024 May 17. doi: 10.1158/0008-5472.CAN-23-3548. Online ahead of print.ABSTRACTNeoadjuvant therapy (NAT) is routinely used in pancreatic ductal adenocarcinoma (PDAC), but not all tumors respond to this treatment. Current clinical imaging techniques are not able to precisely evaluate and predict the response to neoadjuvant therapies over several weeks. A strong fibrotic reaction is a hallmark of a positive response, and during fibrogenesis allysine residues are formed on collagen proteins by the action of lysyl oxidases (LOX). Here we report the application of an allysine-targeted molecular magnetic resonance imaging (MRI) probe, MnL3, to provide an early, noninvasive assessment of treatment response in PDAC. Allysine increased 2- to 3-fold after one dose of NAT with FOLFIRINOX in sensitive human PDAC xenografts in mice. Molecular MRI with MnL3 could specifically detect and quantify fibrogenesis in PDAC xenografts. Comparing the MnL3 signal before and 3 days after one dose of FOLFIRINOX predicted subsequent treatment response. The MnL3 tumor signal increased by 70% from day 0 to day 3 in mice that responded to subsequent doses of FOLFIRINOX, while no signal increase was observed in FOLFIRINOX-resistant tumors. This study indicates the promise of allysine-targeted molecular MRI as a noninvasive tool to predict chemotherapy outcomes.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38759082/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38759082</a> | DOI:<a href=https://doi.org/10.1158/0008-5472.CAN-23-3548>10.1158/0008-5472.CAN-23-3548</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38759082</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Hua Ma</dc:creator>
<dc:creator>Shadi A Esfahani</dc:creator>
<dc:creator>Shriya Krishna</dc:creator>
<dc:creator>Bahar Ataeinia</dc:creator>
<dc:creator>Iris Y Zhou</dc:creator>
<dc:creator>Nicholas J Rotile</dc:creator>
<dc:creator>Jonah Weigand-Whittier</dc:creator>
<dc:creator>Avery T Boice</dc:creator>
<dc:creator>Andrew S Liss</dc:creator>
<dc:creator>Kenneth K Tanabe</dc:creator>
<dc:creator>Peter Caravan</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Cancer research</dc:source>
<dc:title>Allysine-Targeted Molecular MRI Enables Early Prediction of Chemotherapy Response in Pancreatic Cancer</dc:title>
<dc:identifier>pmid:38759082</dc:identifier>
<dc:identifier>doi:10.1158/0008-5472.CAN-23-3548</dc:identifier>
</item>
<item>
<title>Screening p-hackers: Dissemination noise as bait</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38758697/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>We show that adding noise before publishing data effectively screens [Formula: see text]-hacked findings: spurious explanations produced by fitting many statistical models (data mining). Noise creates "baits" that affect two types of researchers differently. Uninformed [Formula: see text]-hackers, who are fully ignorant of the true mechanism and engage in data mining, often fall for baits. Informed researchers, who start with an ex ante hypothesis, are minimally affected. We show that as the...</description>
<content:encoded><![CDATA[<div>Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2400787121. doi: 10.1073/pnas.2400787121. Epub 2024 May 17.ABSTRACTWe show that adding noise before publishing data effectively screens [Formula: see text]-hacked findings: spurious explanations produced by fitting many statistical models (data mining). Noise creates "baits" that affect two types of researchers differently. Uninformed [Formula: see text]-hackers, who are fully ignorant of the true mechanism and engage in data mining, often fall for baits. Informed researchers, who start with an ex ante hypothesis, are minimally affected. We show that as the number of observations grows large, dissemination noise asymptotically achieves optimal screening. In a tractable special case where the informed researchers' theory can identify the true causal mechanism with very few data, we characterize the optimal level of dissemination noise and highlight the relevant trade-offs. Dissemination noise is a tool that statistical agencies currently use to protect privacy. We argue this existing practice can be repurposed to screen [Formula: see text]-hackers and thus improve research credibility.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38758697/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38758697</a> | DOI:<a href=https://doi.org/10.1073/pnas.2400787121>10.1073/pnas.2400787121</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38758697</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Federico Echenique</dc:creator>
<dc:creator>Kevin He</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Proceedings of the National Academy of Sciences of the United States of America</dc:source>
<dc:title>Screening p-hackers: Dissemination noise as bait</dc:title>
<dc:identifier>pmid:38758697</dc:identifier>
<dc:identifier>doi:10.1073/pnas.2400787121</dc:identifier>
</item>
<item>
<title>A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38758646/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin. Here, through live-cell imaging, we quantify the alterations in PARP1 dynamics and activity elicited by seven PARPis over a wide range of concentrations to deliver a unified mechanism of PARPi-induced PARP1 chromatin retention. We find that gross PARP1 retention at DNA damage sites is jointly governed by catalytic inhibition and allosteric...</description>
<content:encoded><![CDATA[<div>Cell Rep. 2024 May 16;43(5):114234. doi: 10.1016/j.celrep.2024.114234. Online ahead of print.ABSTRACTPoly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin. Here, through live-cell imaging, we quantify the alterations in PARP1 dynamics and activity elicited by seven PARPis over a wide range of concentrations to deliver a unified mechanism of PARPi-induced PARP1 chromatin retention. We find that gross PARP1 retention at DNA damage sites is jointly governed by catalytic inhibition and allosteric trapping, albeit in a strictly independent manner-catalytic inhibition causes multiple unproductive binding-dissociation cycles of PARP1, while allosteric trapping prolongs the lesion-bound state of PARP1 to greatly increase overall retention. Importantly, stronger PARP1 retention produces greater temporal shifts in downstream DNA repair events and superior cytotoxicity, highlighting PARP1 retention, a complex but precisely quantifiable characteristic of PARPis, as a valuable biomarker for PARPi efficacy. Our approach can be promptly repurposed for interrogating the properties of DNA-repair-targeting compounds beyond PARPis.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38758646/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38758646</a> | DOI:<a href=https://doi.org/10.1016/j.celrep.2024.114234>10.1016/j.celrep.2024.114234</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38758646</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Petar-Bogomil Kanev</dc:creator>
<dc:creator>Sylvia Varhoshkova</dc:creator>
<dc:creator>Irina Georgieva</dc:creator>
<dc:creator>Maria Lukarska</dc:creator>
<dc:creator>Dilyana Kirova</dc:creator>
<dc:creator>Georgi Danovski</dc:creator>
<dc:creator>Stoyno Stoynov</dc:creator>
<dc:creator>Radoslav Aleksandrov</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Cell reports</dc:source>
<dc:title>A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells</dc:title>
<dc:identifier>pmid:38758646</dc:identifier>
<dc:identifier>doi:10.1016/j.celrep.2024.114234</dc:identifier>
</item>
<item>
<title>Near Infrared Autofluorescence Lifetime Imaging of Human Retinal Pigment Epithelium Using Adaptive Optics Scanning Light Ophthalmoscopy</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38758638/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: NIR-AOFLIO was repeatable and allowed visualization of the RPE cellular mosaic. An observed signal in only the pigmented mouse extract infers the fluorescence signal originates predominantly from melanin. Variations observed across the retina with intermediate age-related macular degeneration suggest NIR-AOFLIO may act as a functional measure of a biomarker for in vivo monitoring of early alterations in retinal health.</description>
<content:encoded><![CDATA[<div>Invest Ophthalmol Vis Sci. 2024 May 1;65(5):27. doi: 10.1167/iovs.65.5.27.ABSTRACTPURPOSE: To demonstrate the first near-infrared adaptive optics fluorescence lifetime imaging ophthalmoscopy (NIR-AOFLIO) measurements in vivo of the human retinal pigment epithelial (RPE) cellular mosaic and to visualize lifetime changes at different retinal eccentricities.METHODS: NIR reflectance and autofluorescence were captured using a custom adaptive optics scanning light ophthalmoscope in 10 healthy subjects (23-64 years old) at seven eccentricities and in two eyes with retinal abnormalities. Repeatability was assessed across two visits up to 8 weeks apart. Endogenous retinal fluorophores and hydrophobic whole retinal extracts of Abca4-/- pigmented and albino mice were imaged to probe the fluorescence origin of NIR-AOFLIO.RESULTS: The RPE mosaic was resolved at all locations in five of seven younger subjects (<35 years old). The mean lifetime across near-peripheral regions (8° and 12°) was longer compared to near-foveal regions (0° and 2°). Repeatability across two visits showed moderate to excellent correlation (intraclass correlation: 0.88 [τm], 0.75 [τ1], 0.65 [τ2], 0.98 [a1]). The mean lifetime across drusen-containing eyes was longer than in age-matched healthy eyes. Fluorescence was observed in only the extracts from pigmented Abca4-/- mouse.CONCLUSIONS: NIR-AOFLIO was repeatable and allowed visualization of the RPE cellular mosaic. An observed signal in only the pigmented mouse extract infers the fluorescence signal originates predominantly from melanin. Variations observed across the retina with intermediate age-related macular degeneration suggest NIR-AOFLIO may act as a functional measure of a biomarker for in vivo monitoring of early alterations in retinal health.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38758638/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38758638</a> | DOI:<a href=https://doi.org/10.1167/iovs.65.5.27>10.1167/iovs.65.5.27</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38758638</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Karteek Kunala</dc:creator>
<dc:creator>Janet A H Tang</dc:creator>
<dc:creator>Kristen E Bowles Johnson</dc:creator>
<dc:creator>Khang T Huynh</dc:creator>
<dc:creator>Keith Parkins</dc:creator>
<dc:creator>Hye-Jin Kim</dc:creator>
<dc:creator>Qiang Yang</dc:creator>
<dc:creator>Janet R Sparrow</dc:creator>
<dc:creator>Jennifer J Hunter</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Investigative ophthalmology & visual science</dc:source>
<dc:title>Near Infrared Autofluorescence Lifetime Imaging of Human Retinal Pigment Epithelium Using Adaptive Optics Scanning Light Ophthalmoscopy</dc:title>
<dc:identifier>pmid:38758638</dc:identifier>
<dc:identifier>doi:10.1167/iovs.65.5.27</dc:identifier>
</item>
<item>
<title>The Impact of Back Optic Zone Design in Orthokeratology on Visual Performance</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38758570/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: The difference induced by varying OZD was significant only in the smaller pupil condition. The selection of OZD in OrthoK designs in real-world patient management should be done while considering individual pupil size.</description>
<content:encoded><![CDATA[<div>Transl Vis Sci Technol. 2024 May 1;13(5):12. doi: 10.1167/tvst.13.5.12.ABSTRACTPURPOSE: To evaluate the visual performance in adolescents undergoing orthokeratology (OrthoK) treatment with two different optical zone diameters (OZDs).METHODS: This randomized, double-masked, self-controlled prospective study was conducted at Tianjin Eye Hospital (Tianjin, China) in June 2022. Thirty-six eligible schoolchildren were enrolled and fitted with corneal refractive therapy lenses with two sizes of OZDs (5 mm [5OZ] and 6 mm [6OZ]). Each participant was randomized to wear the 5OZ in one eye and the 6OZ in the contralateral eye. Subjective visual quality was assessed using visual acuity, refraction, contrast sensitivity function, and visual symptoms, and the objective optical quality was assessed using ocular higher order aberrations (HOAs) and modulation transfer function (MTF).RESULTS: Thirty-five myopic children completed a 1-month follow-up visit. The 5OZ lens induced significantly smaller treatment zone diameters than the 6OZ lens (P < 0.001). Subjective visual quality did not differ significantly between the two groups. Compared to baseline, aberrations of Z40, coma-like, spherical-like, and total HOAs in both groups increased significantly (P < 0.05). For the 3-mm pupils, spherical aberration in the 5OZ group was significantly higher than that in the 6OZ group (P < 0.05). The MTF value of the 6OZ group was significantly higher than that of 5OZ group for 0.3 and 1.5 cycles per degree for the 3-mm pupils (P = 0.006 and P = 0.026, respectively). However, HOAs or MTF did not differ significantly between the two groups for the 5-mm pupils.CONCLUSIONS: The difference induced by varying OZD was significant only in the smaller pupil condition. The selection of OZD in OrthoK designs in real-world patient management should be done while considering individual pupil size.TRANSLATIONAL RELEVANCE: This study revealed that the objective visual quality of small OZD lenses was only slightly affected for the small pupil size.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38758570/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38758570</a> | DOI:<a href=https://doi.org/10.1167/tvst.13.5.12>10.1167/tvst.13.5.12</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38758570</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Xiaoqin Chen</dc:creator>
<dc:creator>Ying Guo</dc:creator>
<dc:creator>Hua Bi</dc:creator>
<dc:creator>Xuewei Liu</dc:creator>
<dc:creator>Yiyuan Wu</dc:creator>
<dc:creator>Ting Wang</dc:creator>
<dc:creator>Lihua Li</dc:creator>
<dc:creator>Wenli Lu</dc:creator>
<dc:creator>Maria Liu</dc:creator>
<dc:creator>Yan Wang</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Translational vision science & technology</dc:source>
<dc:title>The Impact of Back Optic Zone Design in Orthokeratology on Visual Performance</dc:title>
<dc:identifier>pmid:38758570</dc:identifier>
<dc:identifier>doi:10.1167/tvst.13.5.12</dc:identifier>
</item>
<item>
<title>Estimating and Rewarding the Value of Healthcare Interventions Beyond the Healthcare Sector: A Conceptual Framework</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38758291/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: The conceptual framework provides insights for enhancing HTAs to incorporate the broader economic and societal impacts of healthcare interventions. By integrating DCEA, extended HTA analysis with input-output modeling, and a voting scheme, decision makers can make informed choices aligned with societal priorities, although further research and validation are necessary for practical implementation across diverse healthcare contexts.</description>
<content:encoded><![CDATA[<div>Pharmacoeconomics. 2024 May 17. doi: 10.1007/s40273-024-01392-w. Online ahead of print.ABSTRACTBACKGROUND: Evaluating healthcare interventions for their impacts beyond health outcomes may result in recognition of changes in human capital, income level, tax revenue, and government spending, which could affect economic growth and population health. In this paper, we document instances where current health technology assessment (HTA) practices fail to account for the impacts of healthcare interventions on broader society beyond the healthcare sector.METHODS: We propose a novel conceptual framework, highlighting its three components (distributional cost-effectiveness analysis [DCEA], input-output model, and voting scheme) and their contributions to capturing the economic and societal ripple effects of healthcare interventions. This manuscript also outlines a case study in which the framework is applied to the reassessment of a previously evaluated digital health therapeutic for the treatment of opioid use disorder (OUD) compared with standard of care, demonstrating its practical application.RESULTS: The DCEA health value metric indicates that digital therapeutic is more equitable, favoring socioeconomically disadvantaged groups, while standard of care exacerbates health inequality by benefiting the already advantaged. Additionally, digital therapeutic shows potential for boosting productivity, raising income, and creating jobs, supporting its consideration by employer-sponsored health plans to optimize resource allocation for treating OUD.CONCLUSION: The conceptual framework provides insights for enhancing HTAs to incorporate the broader economic and societal impacts of healthcare interventions. By integrating DCEA, extended HTA analysis with input-output modeling, and a voting scheme, decision makers can make informed choices aligned with societal priorities, although further research and validation are necessary for practical implementation across diverse healthcare contexts.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38758291/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38758291</a> | DOI:<a href=https://doi.org/10.1007/s40273-024-01392-w>10.1007/s40273-024-01392-w</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38758291</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Askal Ayalew Ali</dc:creator>
<dc:creator>Amit Kulkarni</dc:creator>
<dc:creator>Sandipan Bhattacharjee</dc:creator>
<dc:creator>Vakaramoko Diaby</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>PharmacoEconomics</dc:source>
<dc:title>Estimating and Rewarding the Value of Healthcare Interventions Beyond the Healthcare Sector: A Conceptual Framework</dc:title>
<dc:identifier>pmid:38758291</dc:identifier>
<dc:identifier>doi:10.1007/s40273-024-01392-w</dc:identifier>
</item>
<item>
<title>Molecular beam scattering of ammonia from a dodecane flat liquid jet</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38757959/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The evaporation and scattering of ND(3) from a dodecane flat liquid jet are investigated and the results are compared with previous studies on molecular beam scattering from liquid surfaces. Evaporation is well-described by a Maxwell-Boltzmann flux distribution with a cos θ angular distribution at the liquid temperature. Scattering experiments at E(i) = 28.8 kJ mol^(-1) over a range of deflection angles show evidence for impulsive scattering and thermal desorption. At a deflection angle of 90°,...</description>
<content:encoded><![CDATA[<div>Faraday Discuss. 2024 May 17. doi: 10.1039/d3fd00169e. Online ahead of print.ABSTRACTThe evaporation and scattering of ND3 from a dodecane flat liquid jet are investigated and the results are compared with previous studies on molecular beam scattering from liquid surfaces. Evaporation is well-described by a Maxwell-Boltzmann flux distribution with a cos θ angular distribution at the liquid temperature. Scattering experiments at Ei = 28.8 kJ mol-1 over a range of deflection angles show evidence for impulsive scattering and thermal desorption. At a deflection angle of 90°, the thermal desorption fraction is 0.49, which is higher than that of other molecules previously scattered from dodecane and consistent with work performed on NH3 scattering from a squalane-wetted wheel. ND3 scattering from dodecane results in super-specular scattering, as seen in previous experiments on dodecane. The impulsive scattering channel is fitted to a "soft-sphere" model, yielding an effective surface mass of 55 amu and an internal excitation of 5.08 kJ mol-1. Overall, impulsively scattered ND3 behaves similarly to other small molecules scattered from dodecane.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38757959/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38757959</a> | DOI:<a href=https://doi.org/10.1039/d3fd00169e>10.1039/d3fd00169e</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38757959</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Steven Saric</dc:creator>
<dc:creator>Walt Yang</dc:creator>
<dc:creator>Daniel M Neumark</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Faraday discussions</dc:source>
<dc:title>Molecular beam scattering of ammonia from a dodecane flat liquid jet</dc:title>
<dc:identifier>pmid:38757959</dc:identifier>
<dc:identifier>doi:10.1039/d3fd00169e</dc:identifier>
</item>
<item>
<title>The Better Care Plan: a blueprint for improving America's healthcare system</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38756832/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The United States falls far short of its potential for delivering care that is effective, efficient, safe, timely, patient-centered, and equitable. We put forward the Better Care Plan, an overarching blueprint to address the flaws in our current system. The plan calls for continuously improving care, moving all payers to risk-adjusted prospective payment, and creating national entities for collecting, analyzing, and reporting patient safety and quality-of-care outcomes data. A number of...</description>
<content:encoded><![CDATA[<div>Health Aff Sch. 2023 Jun 20;1(1):qxad007. doi: 10.1093/haschl/qxad007. eCollection 2023 Jul.ABSTRACTThe United States falls far short of its potential for delivering care that is effective, efficient, safe, timely, patient-centered, and equitable. We put forward the Better Care Plan, an overarching blueprint to address the flaws in our current system. The plan calls for continuously improving care, moving all payers to risk-adjusted prospective payment, and creating national entities for collecting, analyzing, and reporting patient safety and quality-of-care outcomes data. A number of recommendations are made to achieve these goals.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38756832/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38756832</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10986211/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC10986211</a> | DOI:<a href=https://doi.org/10.1093/haschl/qxad007>10.1093/haschl/qxad007</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38756832</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Stephen M Shortell</dc:creator>
<dc:creator>John S Toussaint</dc:creator>
<dc:creator>George C Halvorson</dc:creator>
<dc:creator>Jon M Kingsdale</dc:creator>
<dc:creator>Richard M Scheffler</dc:creator>
<dc:creator>Allyson Y Schwartz</dc:creator>
<dc:creator>Peter A Wadsworth</dc:creator>
<dc:creator>Gail Wilensky</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Health affairs scholar</dc:source>
<dc:title>The Better Care Plan: a blueprint for improving America's healthcare system</dc:title>
<dc:identifier>pmid:38756832</dc:identifier>
<dc:identifier>pmc:PMC10986211</dc:identifier>
<dc:identifier>doi:10.1093/haschl/qxad007</dc:identifier>
</item>
<item>
<title>The association of safety-net program participation with government perceptions, welfare stigma, and discrimination</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38756395/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Safety-net programs in the United States offered critical support to counter food insecurity and poverty during the first year of the COVID-19 pandemic. The Supplemental Nutrition Assistance Program (SNAP) and the Earned Income Tax Credit (EITC) are both means-tested programs with significant benefits. Take-up of SNAP and EITC is lower in California than nationwide and reasons for this difference are unclear. We examined associations of participation in SNAP and receipt of the EITC and...</description>
<content:encoded><![CDATA[<div>Health Aff Sch. 2023 Dec 21;2(1):qxad084. doi: 10.1093/haschl/qxad084. eCollection 2024 Jan.ABSTRACTSafety-net programs in the United States offered critical support to counter food insecurity and poverty during the first year of the COVID-19 pandemic. The Supplemental Nutrition Assistance Program (SNAP) and the Earned Income Tax Credit (EITC) are both means-tested programs with significant benefits. Take-up of SNAP and EITC is lower in California than nationwide and reasons for this difference are unclear. We examined associations of participation in SNAP and receipt of the EITC and perceptions of the US government, 2 types of welfare stigma (program stigma and social stigma), and perceived discrimination. We interviewed a sample of 497 caregivers of young children from families with low income in California during the COVID-19 pandemic (August 2020-May 2021). We found that participation in SNAP (odds ratio [OR] = 1.24 [1.05, 1.47]) and receiving the EITC (OR = 1.39 [1.05, 1.84]) were both associated with greater reported perceptions of social stigma, but not with perceptions of government, program stigma, or discrimination. Among food-insecure respondents, we found that participation in SNAP was additionally associated with program stigma and discrimination. These findings suggest that perceived social stigma may be a reason that people with low income may not participate in programs for which they are eligible.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38756395/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38756395</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC10986270/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC10986270</a> | DOI:<a href=https://doi.org/10.1093/haschl/qxad084>10.1093/haschl/qxad084</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38756395</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Richard Pulvera</dc:creator>
<dc:creator>Kaitlyn Jackson</dc:creator>
<dc:creator>Wendi Gosliner</dc:creator>
<dc:creator>Rita Hamad</dc:creator>
<dc:creator>Lia C H Fernald</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Health affairs scholar</dc:source>
<dc:title>The association of safety-net program participation with government perceptions, welfare stigma, and discrimination</dc:title>
<dc:identifier>pmid:38756395</dc:identifier>
<dc:identifier>pmc:PMC10986270</dc:identifier>
<dc:identifier>doi:10.1093/haschl/qxad084</dc:identifier>
</item>
<item>
<title>Bifurcation delay and front propagation in the real Ginzburg-Landau equation on a time-dependent domain</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38755931/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>This work analyzes bifurcation delay and front propagation in the one-dimensional real Ginzburg-Landau equation with periodic boundary conditions on isotropically growing or shrinking domains. First, we obtain closed-form expressions for the delay of primary bifurcations on a growing domain and show that the additional domain growth before the appearance of a pattern is independent of the growth time scale. We also quantify primary bifurcation delay on a shrinking domain; in contrast with a...</description>
<content:encoded><![CDATA[<div>Phys Rev E. 2024 Apr;109(4-1):044210. doi: 10.1103/PhysRevE.109.044210.ABSTRACTThis work analyzes bifurcation delay and front propagation in the one-dimensional real Ginzburg-Landau equation with periodic boundary conditions on isotropically growing or shrinking domains. First, we obtain closed-form expressions for the delay of primary bifurcations on a growing domain and show that the additional domain growth before the appearance of a pattern is independent of the growth time scale. We also quantify primary bifurcation delay on a shrinking domain; in contrast with a growing domain, the time scale of domain compression is reflected in the additional compression before the pattern decays. For secondary bifurcations such as the Eckhaus instability, we obtain a lower bound on the delay of phase slips due to a time-dependent domain. We also construct a heuristic model to classify regimes with arrested phase slips, i.e., phase slips that fail to develop. Then, we study how propagating fronts are influenced by a time-dependent domain. We identify three types of pulled fronts: homogeneous, pattern spreading, and Eckhaus fronts. By following the linear dynamics, we derive expressions for the velocity and profile of homogeneous fronts on a time-dependent domain. We also derive the natural "asymptotic" velocity and front profile and show that these deviate from predictions based on the marginal stability criterion familiar from fixed domain theory. This difference arises because the time dependence of the domain lifts the degeneracy of the spatial eigenvalues associated with speed selection and represents a fundamental distinction from the fixed domain theory that we verify using direct numerical simulations. The effect of a growing domain on pattern spreading and Eckhaus front velocities is inspected qualitatively and found to be similar to that of homogeneous fronts. These more complex fronts can also experience delayed onset. Lastly, we show that dilution-an effect present when the order parameter is conserved-increases bifurcation delay and amplifies changes in the homogeneous front velocity on time-dependent domains. The study provides general insight into the effects of domain growth on pattern onset, pattern transitions, and front propagation in systems across different scientific fields.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38755931/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38755931</a> | DOI:<a href=https://doi.org/10.1103/PhysRevE.109.044210>10.1103/PhysRevE.109.044210</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38755931</guid>
<pubDate>Fri, 17 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Troy Tsubota</dc:creator>
<dc:creator>Chang Liu</dc:creator>
<dc:creator>Benjamin Foster</dc:creator>
<dc:creator>Edgar Knobloch</dc:creator>
<dc:date>2024-05-17</dc:date>
<dc:source>Physical review. E</dc:source>
<dc:title>Bifurcation delay and front propagation in the real Ginzburg-Landau equation on a time-dependent domain</dc:title>
<dc:identifier>pmid:38755931</dc:identifier>
<dc:identifier>doi:10.1103/PhysRevE.109.044210</dc:identifier>
</item>
<item>
<title>Intercalation in 2D materials and in situ studies</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38755296/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Intercalation of atoms, ions and molecules is a powerful tool for altering or tuning the properties - interlayer interactions, in-plane bonding configurations, Fermi-level energies, electronic band structures and spin-orbit coupling - of 2D materials. Intercalation can induce property changes in materials related to photonics, electronics, optoelectronics, thermoelectricity, magnetism, catalysis and energy storage, unlocking or improving the potential of 2D materials in present and future...</description>
<content:encoded><![CDATA[<div>Nat Rev Chem. 2024 May 16. doi: 10.1038/s41570-024-00605-2. Online ahead of print.ABSTRACTIntercalation of atoms, ions and molecules is a powerful tool for altering or tuning the properties - interlayer interactions, in-plane bonding configurations, Fermi-level energies, electronic band structures and spin-orbit coupling - of 2D materials. Intercalation can induce property changes in materials related to photonics, electronics, optoelectronics, thermoelectricity, magnetism, catalysis and energy storage, unlocking or improving the potential of 2D materials in present and future applications. In situ imaging and spectroscopy technologies are used to visualize and trace intercalation processes. These techniques provide the opportunity for deciphering important and often elusive intercalation dynamics, chemomechanics and mechanisms, such as the intercalation pathways, reversibility, uniformity and speed. In this Review, we discuss intercalation in 2D materials, beginning with a brief introduction of the intercalation strategies, then we look into the atomic and intrinsic effects of intercalation, followed by an overview of their in situ studies, and finally provide our outlook.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38755296/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38755296</a> | DOI:<a href=https://doi.org/10.1038/s41570-024-00605-2>10.1038/s41570-024-00605-2</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38755296</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Ruijie Yang</dc:creator>
<dc:creator>Liang Mei</dc:creator>
<dc:creator>Zhaoyang Lin</dc:creator>
<dc:creator>Yingying Fan</dc:creator>
<dc:creator>Jongwoo Lim</dc:creator>
<dc:creator>Jinghua Guo</dc:creator>
<dc:creator>Yijin Liu</dc:creator>
<dc:creator>Hyeon Suk Shin</dc:creator>
<dc:creator>Damien Voiry</dc:creator>
<dc:creator>Qingye Lu</dc:creator>
<dc:creator>Ju Li</dc:creator>
<dc:creator>Zhiyuan Zeng</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Nature reviews. Chemistry</dc:source>
<dc:title>Intercalation in 2D materials and in situ studies</dc:title>
<dc:identifier>pmid:38755296</dc:identifier>
<dc:identifier>doi:10.1038/s41570-024-00605-2</dc:identifier>
</item>
<item>
<title>Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38753487/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>R2 non-long terminal repeat (non-LTR) retrotransposons are among the most extensively distributed mobile genetic elements in multicellular eukaryotes and show promise for applications in transgene supplementation of the human genome. They insert new gene copies into a conserved site in 28S ribosomal DNA with exquisite specificity. R2 clades are defined by the number of zinc fingers (ZFs) at the N terminus of the retrotransposon-encoded protein, postulated to additively confer DNA site...</description>
<content:encoded><![CDATA[<div>Cell Rep. 2024 May 15;43(5):114239. doi: 10.1016/j.celrep.2024.114239. Online ahead of print.ABSTRACTR2 non-long terminal repeat (non-LTR) retrotransposons are among the most extensively distributed mobile genetic elements in multicellular eukaryotes and show promise for applications in transgene supplementation of the human genome. They insert new gene copies into a conserved site in 28S ribosomal DNA with exquisite specificity. R2 clades are defined by the number of zinc fingers (ZFs) at the N terminus of the retrotransposon-encoded protein, postulated to additively confer DNA site specificity. Here, we illuminate general principles of DNA recognition by R2 N-terminal domains across and between clades, with extensive, specific recognition requiring only one or two compact domains. DNA-binding and protection assays demonstrate broadly shared as well as clade-specific DNA interactions. Gene insertion assays in cells identify the N-terminal domains sufficient for target-site insertion and reveal roles in second-strand cleavage or synthesis for clade-specific ZFs. Our results have implications for understanding evolutionary diversification of non-LTR retrotransposon insertion mechanisms and the design of retrotransposon-based gene therapies.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38753487/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38753487</a> | DOI:<a href=https://doi.org/10.1016/j.celrep.2024.114239>10.1016/j.celrep.2024.114239</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38753487</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Rosa Jooyoung Lee</dc:creator>
<dc:creator>Connor A Horton</dc:creator>
<dc:creator>Briana Van Treeck</dc:creator>
<dc:creator>Jeremy J R McIntyre</dc:creator>
<dc:creator>Kathleen Collins</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Cell reports</dc:source>
<dc:title>Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains</dc:title>
<dc:identifier>pmid:38753487</dc:identifier>
<dc:identifier>doi:10.1016/j.celrep.2024.114239</dc:identifier>
</item>
<item>
<title>A functional survey of the regulatory landscape of estrogen-receptor-positive breast cancer evolution</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38753319/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Only a handful of somatic alterations have been linked to endocrine therapy resistance in hormone-dependent breast cancer (HDBC), potentially explaining ~40% of relapses. If other mechanisms underlie the evolution of HDBC under adjuvant therapy is currently unknown. In this work, we employ functional genomics to dissect the contribution of cis-regulatory elements (CREs) to cancer evolution by focusing on 12 megabases of non-coding DNA, including clonal enhancers, gene promoters, and boundaries...</description>
<content:encoded><![CDATA[<div>Cancer Discov. 2024 May 16. doi: 10.1158/2159-8290.CD-23-1157. Online ahead of print.ABSTRACTOnly a handful of somatic alterations have been linked to endocrine therapy resistance in hormone-dependent breast cancer (HDBC), potentially explaining ~40% of relapses. If other mechanisms underlie the evolution of HDBC under adjuvant therapy is currently unknown. In this work, we employ functional genomics to dissect the contribution of cis-regulatory elements (CREs) to cancer evolution by focusing on 12 megabases of non-coding DNA, including clonal enhancers, gene promoters, and boundaries of topologically associating domains. Parallel epigenetic perturbation (CRISPRi) in vitro reveals context-dependent roles for many of these CREs, with a specific impact on dormancy entrance and endocrine therapy resistance. Profiling of CRE somatic alterations in a unique, longitudinal cohort of patients treated with endocrine therapies identifies a limited set of non-coding changes potentially involved in therapy resistance. Overall, our data uncover how endocrine therapies triggers the emergence of transient features which could ultimately be exploited to hinder the adaptive process.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38753319/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38753319</a> | DOI:<a href=https://doi.org/10.1158/2159-8290.CD-23-1157>10.1158/2159-8290.CD-23-1157</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38753319</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Iros Barozzi</dc:creator>
<dc:creator>Neil Slaven</dc:creator>
<dc:creator>Eleonora Canale</dc:creator>
<dc:creator>Rui Lopes</dc:creator>
<dc:creator>Ines Amorim Monteiro Barbosa</dc:creator>
<dc:creator>Melusine Bleu</dc:creator>
<dc:creator>Diana Ivanoiu</dc:creator>
<dc:creator>Claudia Pacini</dc:creator>
<dc:creator>Emanuela Mensa</dc:creator>
<dc:creator>Alfie Chambers</dc:creator>
<dc:creator>Sara Bravaccini</dc:creator>
<dc:creator>Sara Ravaioli</dc:creator>
<dc:creator>Balazs Gyorffy</dc:creator>
<dc:creator>Maria Vittoria Dieci</dc:creator>
<dc:creator>Giancarlo Pruneri</dc:creator>
<dc:creator>Giorgio G Galli</dc:creator>
<dc:creator>Luca Magnani</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Cancer discovery</dc:source>
<dc:title>A functional survey of the regulatory landscape of estrogen-receptor-positive breast cancer evolution</dc:title>
<dc:identifier>pmid:38753319</dc:identifier>
<dc:identifier>doi:10.1158/2159-8290.CD-23-1157</dc:identifier>
</item>
<item>
<title>Erratum: A Constrained Metropolis-Hastings Robbins-Monro Algorithm for Q Matrix Estimation in DINA Models</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38753255/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>No abstract</description>
<content:encoded><![CDATA[<div>Psychometrika. 2024 May 16. doi: 10.1007/s11336-024-09974-5. Online ahead of print.NO ABSTRACTPMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38753255/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38753255</a> | DOI:<a href=https://doi.org/10.1007/s11336-024-09974-5>10.1007/s11336-024-09974-5</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38753255</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Chen-Wei Liu</dc:creator>
<dc:creator>Björn Andersson</dc:creator>
<dc:creator>Anders Skrondal</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Psychometrika</dc:source>
<dc:title>Erratum: A Constrained Metropolis-Hastings Robbins-Monro Algorithm for Q Matrix Estimation in DINA Models</dc:title>
<dc:identifier>pmid:38753255</dc:identifier>
<dc:identifier>doi:10.1007/s11336-024-09974-5</dc:identifier>
</item>
<item>
<title>Water Fluoridation and Birth Outcomes in California</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38752991/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: We estimated that a reduction in water fluoride levels would modestly decrease birth weight and birth-weight-for-gestational-age z-scores in California. https://doi.org/10.1289/EHP13732.</description>
<content:encoded><![CDATA[<div>Environ Health Perspect. 2024 May;132(5):57004. doi: 10.1289/EHP13732. Epub 2024 May 16.ABSTRACTBACKGROUND: There is a lack of research on the relationship between water fluoridation and pregnancy outcomes.OBJECTIVES: We assessed whether hypothetical interventions to reduce fluoride levels would improve birth outcomes in California.METHODS: We linked California birth records from 2000 to 2018 to annual average fluoride levels by community water system. Fluoride levels were collected from consumer confidence reports using publicly available data and public record requests. We estimated the effects of a hypothetical intervention reducing water fluoride levels to <mml:math><mml:mrow><mml:mn>0.7</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math> (the current level recommended by the US Department of Health and Human Services) and <mml:math><mml:mrow><mml:mn>0.5</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math> (below the current recommendation) on birth weight, birth-weight-for-gestational age z-scores, gestational age, preterm birth, small-for-gestational age, large-for-gestational age, and macrosomia using linear regression with natural cubic splines and G-computation. Inference was calculated using a clustered bootstrap with Wald-type confidence intervals. We evaluated race/ethnicity, health insurance type, fetal sex, and arsenic levels as potential effect modifiers.RESULTS: Fluoride levels ranged from 0 to <mml:math><mml:mrow><mml:mn>2.5</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math>, with a median of <mml:math><mml:mrow><mml:mn>0.51</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math>. There was a small negative association on birth weight with the hypothetical intervention to reduce fluoride levels to <mml:math><mml:mrow><mml:mn>0.7</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math> [<mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>2.2</mml:mn><mml:mspace></mml:mspace><mml:mi>g</mml:mi></mml:mrow></mml:math>; 95% confidence interval (CI): <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>4.4</mml:mn></mml:mrow></mml:math>, 0.0] and to <mml:math><mml:mrow><mml:mn>0.5</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math> (<mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>5.8</mml:mn><mml:mspace></mml:mspace><mml:mi>g</mml:mi></mml:mrow></mml:math>; 95% CI: <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>10.0</mml:mn></mml:mrow></mml:math>, <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>1.6</mml:mn></mml:mrow></mml:math>). There were small negative associations with birth-weight-for-gestational-age z-scores for both hypothetical interventions (<mml:math><mml:mrow><mml:mn>0.7</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math>: <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>0.004</mml:mn></mml:mrow></mml:math>; 95% CI: <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>0.007</mml:mn></mml:mrow></mml:math>, 0.000 and <mml:math><mml:mrow><mml:mn>0.5</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math>: <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>0.006</mml:mn></mml:mrow></mml:math>; 95% CI: <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>0.013</mml:mn></mml:mrow></mml:math>, 0.000). We also observed small negative associations for risk of large-for-gestational age for both the hypothetical interventions to <mml:math><mml:mrow><mml:mn>0.7</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math> [<mml:math><mml:mrow><mml:mtext>risk difference </mml:mtext><mml:mrow><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mtext>RD</mml:mtext></mml:mrow><mml:mo>)</mml:mo></mml:mrow></mml:mrow><mml:mo>=</mml:mo><mml:mo>-</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>; 95% CI: <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>0.002</mml:mn></mml:mrow></mml:math>, 0.000 and <mml:math><mml:mrow><mml:mn>0.5</mml:mn><mml:mtext> ppm</mml:mtext></mml:mrow></mml:math> (<mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>; 95% CI: <mml:math><mml:mrow><mml:mo>-</mml:mo><mml:mn>0.003</mml:mn></mml:mrow></mml:math>, 0.000)]. We did not observe any associations with preterm birth or with being small for gestational age for either hypothetical intervention. We did not observe any associations with risk of preterm birth or small-for-gestational age for either hypothetical intervention.CONCLUSION: We estimated that a reduction in water fluoride levels would modestly decrease birth weight and birth-weight-for-gestational-age z-scores in California. https://doi.org/10.1289/EHP13732.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38752991/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38752991</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11098007/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11098007</a> | DOI:<a href=https://doi.org/10.1289/EHP13732>10.1289/EHP13732</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38752991</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Dana E Goin</dc:creator>
<dc:creator>Amy M Padula</dc:creator>
<dc:creator>Tracey J Woodruff</dc:creator>
<dc:creator>Allison Sherris</dc:creator>
<dc:creator>Kiley Charbonneau</dc:creator>
<dc:creator>Rachel Morello-Frosch</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Environmental health perspectives</dc:source>
<dc:title>Water Fluoridation and Birth Outcomes in California</dc:title>
<dc:identifier>pmid:38752991</dc:identifier>
<dc:identifier>pmc:PMC11098007</dc:identifier>
<dc:identifier>doi:10.1289/EHP13732</dc:identifier>
</item>
<item>
<title>A Large-Scale Fabrication of Flexible, Ultrathin, and Robust solid Electrolyte for Solid-State Lithium-Sulfur Batteries</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38752837/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>solid-state electrolytes, 3D supporting skeleton, mechanical strength, uniform Li deposition, F-enriched SEIAll-solid-state lithium metal batteries (ASSLMBs) are considered as the most promising candidates for the next-generation high-safety batteries. To achieve high energy density in ASSLMBs, it is essential that the solid-state electrolytes (SSEs) are lightweight, thin, and possess superior electrochemical stability. In this study, we propose a feasible and scalable fabrication approach to...</description>
<content:encoded><![CDATA[<div>Adv Mater. 2024 May 16:e2400115. doi: 10.1002/adma.202400115. Online ahead of print.ABSTRACTsolid-state electrolytes, 3D supporting skeleton, mechanical strength, uniform Li deposition, F-enriched SEIAll-solid-state lithium metal batteries (ASSLMBs) are considered as the most promising candidates for the next-generation high-safety batteries. To achieve high energy density in ASSLMBs, it is essential that the solid-state electrolytes (SSEs) are lightweight, thin, and possess superior electrochemical stability. In this study, we propose a feasible and scalable fabrication approach to construct 3D supporting skeleton using an electro-blown spinning technique. This skeleton not only enhances the mechanical strength, but also hinders the migration of Li-salt anions, improving the lithium-ion transference number of the SSE. This provides a homogeneous distribution of Li-ion flux and local current density, promoting uniform Li deposition. As a result, based on the mechanically robust and thin SSEs, the Li symmetric cells show outstanding Li plating/stripping reversibility. Besides, a stable interface contact between SSE and Li anode has been established with the formation of a F-enriched solid electrolyte interface (SEI) layer. The solid-state Li|sulfurized polyacrylonitrile (Li|SPAN) cell achieves a capacity retention ratio of 94.0% after 350 cycles at 0.5 C. Also, the high-voltage Li|LCO cell shows a capacity retention of 92.4% at 0.5 C after 500 cycles. This fabrication approach for SSEs is applicable for commercially large-scale production and application in high-energy-density and high-safety ASSLMBs. This article is protected by copyright. All rights reserved.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38752837/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38752837</a> | DOI:<a href=https://doi.org/10.1002/adma.202400115>10.1002/adma.202400115</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38752837</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Lu Nie</dc:creator>
<dc:creator>Jinling Zhu</dc:creator>
<dc:creator>Xiaoyan Wu</dc:creator>
<dc:creator>Mengtian Zhang</dc:creator>
<dc:creator>Xiao Xiao</dc:creator>
<dc:creator>Runhua Gao</dc:creator>
<dc:creator>Xinru Wu</dc:creator>
<dc:creator>Yanfei Zhu</dc:creator>
<dc:creator>Shaojie Chen</dc:creator>
<dc:creator>Zhiyuan Han</dc:creator>
<dc:creator>Yi Yu</dc:creator>
<dc:creator>Shaogang Wang</dc:creator>
<dc:creator>Shengjie Ling</dc:creator>
<dc:creator>Guangmin Zhou</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Advanced materials (Deerfield Beach, Fla.)</dc:source>
<dc:title>A Large-Scale Fabrication of Flexible, Ultrathin, and Robust solid Electrolyte for Solid-State Lithium-Sulfur Batteries</dc:title>
<dc:identifier>pmid:38752837</dc:identifier>
<dc:identifier>doi:10.1002/adma.202400115</dc:identifier>
</item>
<item>
<title>Socio-environmental Opportunities for Organic Material Management in California's Sustainability Transition</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38752553/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Contemporary resource management is doubly burdened by high rates of organic material disposal in landfills, generating potent greenhouse gases (GHG), and globally degraded soils, which threaten future food security. Expansion of composting can provide a resilient alternative, by avoiding landfill GHG emissions, returning valuable nutrients to the soil to ensure continued agricultural production, and sequestering carbon while supporting local communities. Recognizing this opportunity, California...</description>
<content:encoded><![CDATA[<div>Environ Sci Technol. 2024 May 16. doi: 10.1021/acs.est.3c10711. Online ahead of print.ABSTRACTContemporary resource management is doubly burdened by high rates of organic material disposal in landfills, generating potent greenhouse gases (GHG), and globally degraded soils, which threaten future food security. Expansion of composting can provide a resilient alternative, by avoiding landfill GHG emissions, returning valuable nutrients to the soil to ensure continued agricultural production, and sequestering carbon while supporting local communities. Recognizing this opportunity, California has set ambitious organics diversion targets in the Short-Lived Climate Pollutant Law (SB1383) which will require significant increases (5 to 8 million tonnes per year) in organic material processing capacity. This paper develops a spatial optimization model to consider how to handle this flow of additional material while achieving myriad social and ecological benefits through compost production. We consider community-based and on-farm facilities alongside centralized, large-scale infrastructure to explore decentralized and diversified alternative futures of composting infrastructure in the state of California. We find using a diversity of facilities would provide opportunity for cost savings while achieving significant emissions reductions of approximately 3.4 ± 1 MMT CO2e and demonstrate that it is possible to incorporate community protection into compost infrastructure planning while meeting economic and environmental objectives.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38752553/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38752553</a> | DOI:<a href=https://doi.org/10.1021/acs.est.3c10711>10.1021/acs.est.3c10711</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38752553</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Anaya L Hall</dc:creator>
<dc:creator>Aleksandra I Ponomareva</dc:creator>
<dc:creator>Margaret S Torn</dc:creator>
<dc:creator>Matthew D Potts</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Environmental science & technology</dc:source>
<dc:title>Socio-environmental Opportunities for Organic Material Management in California's Sustainability Transition</dc:title>
<dc:identifier>pmid:38752553</dc:identifier>
<dc:identifier>doi:10.1021/acs.est.3c10711</dc:identifier>
</item>
<item>
<title>Antibacterial efficacy of copper-based metal-organic frameworks against Escherichia coli and Lactobacillus</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38752161/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The widespread and excessive use of antimicrobial drugs has resulted in a concerning rise in bacterial resistance, leading to a risk of untreatable infections. The aim of this study was to formulate a robust and efficient antibacterial treatment to address this challenge. Previous work focused on the effectiveness of the Cu-BTC metal-organic framework (MOF; BTC stands for 1,3,5-benzenetricarboxylate) in combatting various bacterial strains. Herein, we compare the antibacterial properties of...</description>
<content:encoded><![CDATA[<div>RSC Adv. 2024 May 15;14(22):15821-15831. doi: 10.1039/d4ra01241k. eCollection 2024 May 10.ABSTRACTThe widespread and excessive use of antimicrobial drugs has resulted in a concerning rise in bacterial resistance, leading to a risk of untreatable infections. The aim of this study was to formulate a robust and efficient antibacterial treatment to address this challenge. Previous work focused on the effectiveness of the Cu-BTC metal-organic framework (MOF; BTC stands for 1,3,5-benzenetricarboxylate) in combatting various bacterial strains. Herein, we compare the antibacterial properties of Cu-BTC with our newly designed Cu-GA MOF, consisting of copper ions bridged by deprotonated gallate ligands (H2gal2-), against Escherichia coli (E. coli) and Lactobacillus bacteria. Cu-GA was synthesized hydrothermally from copper salt and naturally derived gallic acid (H4gal) and characterized for antibacterial evaluation. The gradual breakdown of Cu(H2gal) resulted in a significant antibacterial effect that is due to the release of copper ions and gallate ligands from the framework. Both copper MOFs were nontoxic to bacteria at low concentrations and growth was completely inhibited at high concentrations when treated with Cu-BTC (1500 μg for E. coli and 1700 μg for Lactobacillus) and Cu-GA (2000 μg for both bacterial strains). Furthermore, our agarose gel electrophoresis results indicate that both MOFs could disrupt bacterial cell membranes, hindering the synthesis of DNA. These findings confirm the antibacterial properties of Cu-BTC and the successful internalization of Cu2+ ions and gallic acid by bacteria from the Cu-GA MOF framework, suggesting the potential for a sustained and effective therapeutic approach against pathogenic microorganisms.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38752161/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38752161</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11095089/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11095089</a> | DOI:<a href=https://doi.org/10.1039/d4ra01241k>10.1039/d4ra01241k</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38752161</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Sandy Elmehrath</dc:creator>
<dc:creator>Khansa Ahsan</dc:creator>
<dc:creator>Nayla Munawar</dc:creator>
<dc:creator>Ahmed Alzamly</dc:creator>
<dc:creator>Ha L Nguyen</dc:creator>
<dc:creator>Yaser Greish</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>RSC advances</dc:source>
<dc:title>Antibacterial efficacy of copper-based metal-organic frameworks against Escherichia coli and Lactobacillus</dc:title>
<dc:identifier>pmid:38752161</dc:identifier>
<dc:identifier>pmc:PMC11095089</dc:identifier>
<dc:identifier>doi:10.1039/d4ra01241k</dc:identifier>
</item>
<item>
<title>Conceptual framework for preterm birth review in San Francisco</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38751590/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Preterm birth persists as a leading cause of infant mortality and morbidity despite decades of intervention effort. Intervention null effects may reflect failure to account for social determinants of health (SDH) or jointly acting risk factors. In some communities, persistent preterm birth trends and disparities have been consistently associated with SDH such as race/ethnicity, zip code, and housing conditions. Health authorities recommend conceptual frameworks for targeted action on SDH and...</description>
<content:encoded><![CDATA[<div>Front Public Health. 2024 May 1;12:1332972. doi: 10.3389/fpubh.2024.1332972. eCollection 2024.ABSTRACTPreterm birth persists as a leading cause of infant mortality and morbidity despite decades of intervention effort. Intervention null effects may reflect failure to account for social determinants of health (SDH) or jointly acting risk factors. In some communities, persistent preterm birth trends and disparities have been consistently associated with SDH such as race/ethnicity, zip code, and housing conditions. Health authorities recommend conceptual frameworks for targeted action on SDH and precision public health approaches for preterm birth prevention. We document San Francisco, California's experience identifying the need, rationale, methods, and pilot work for developing a conceptual framework for preterm birth review (PTBR) in San Francisco. The PTBR conceptual framework is intended to enable essential public health services in San Francisco that prevent a range of preterm birth phenotypes by guiding plans for data collection, hypothesis testing, analytical methods, reports, and intervention strategy. Key elements of the PTBR conceptual framework are described including, 10 domains of SDH, 9 domains at the whole person level, such as lived experience and health behaviors, 8 domains at the within-person level, such as biomarkers and clinical measures, 18 preterm birth phenotypes, and the interconnections between domains. Assumptions for the PTBR conceptual framework were supported by a scoping review of literature on SDH effects on preterm birth, health authority consensus reports, and PTBR pilot data. Researcher and health authority interest in each of the domains warrants the framework to prompt systematic consideration of variables in each proposed domain. PTBR pilot data, illustrated in heatmaps, confirm the feasibility of data collection based on the framework, prevalence of co-occurring risk factors, potential for joint effects on specific preterm birth phenotypes, and opportunity for intervention to block SDH effects on preterm birth. The proposed PTBR conceptual framework has practical implications for specifying (1) population groups at risk, (2) grids or heatmap visualization of risk factors, (3) multi-level analyses, and (4) multi-component intervention design in terms of patterns of co-occurring risk factors. Lessons learned about PTBR data collection logistics, variable choice, and data management will be incorporated into future work to build PTBR infrastructure based on the PTBR conceptual framework.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38751590/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38751590</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11094341/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11094341</a> | DOI:<a href=https://doi.org/10.3389/fpubh.2024.1332972>10.3389/fpubh.2024.1332972</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38751590</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jodi D Stookey</dc:creator>
<dc:creator>Sylvia Guendelman</dc:creator>
<dc:creator>Brady McCallister</dc:creator>
<dc:creator>Paige Whittemore</dc:creator>
<dc:creator>Deena Abu-Amara</dc:creator>
<dc:creator>Maria A Elsasser</dc:creator>
<dc:creator>Fardowsa Dahir</dc:creator>
<dc:creator>Aline Armstrong</dc:creator>
<dc:creator>Rebecca Jackson</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Frontiers in public health</dc:source>
<dc:title>Conceptual framework for preterm birth review in San Francisco</dc:title>
<dc:identifier>pmid:38751590</dc:identifier>
<dc:identifier>pmc:PMC11094341</dc:identifier>
<dc:identifier>doi:10.3389/fpubh.2024.1332972</dc:identifier>
</item>
<item>
<title>Clinical Implications of HIV Treatment and Prevention for Polygamous Families in Kenya and Uganda: "My Co-Wife Is the One Who Used to Encourage Me"</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38751360/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Polygamy is the practice of marriage to multiple partners. Approximately 6-11% of households in Uganda and 4-11% of households in Kenya are polygamous. The complex families produced by polygamous marriage customs give rise to additional considerations for healthcare providers and public health messaging around HIV care. Using 27 in-depth, semi-structured qualitative interviews with participants in two studies in rural Kenya and Uganda, we analysed challenges and opportunities that polygamous...</description>
<content:encoded><![CDATA[<div>J Int Assoc Provid AIDS Care. 2024 Jan-Dec;23:23259582241255171. doi: 10.1177/23259582241255171.ABSTRACTPolygamy is the practice of marriage to multiple partners. Approximately 6-11% of households in Uganda and 4-11% of households in Kenya are polygamous. The complex families produced by polygamous marriage customs give rise to additional considerations for healthcare providers and public health messaging around HIV care. Using 27 in-depth, semi-structured qualitative interviews with participants in two studies in rural Kenya and Uganda, we analysed challenges and opportunities that polygamous families presented in the diagnosis, treatment and prevention of HIV, and provider roles in improving HIV outcomes in these families. Overall, prevention methods seemed more justifiable to families where co-wives live far apart than when all members live in the same household. In treatment, diagnosis of one member did not always lead to disclosure to other members, creating an adverse home environment; but sometimes diagnosis of one wife led not only to diagnosis of the other, but also to greater household support.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38751360/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38751360</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11100383/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11100383</a> | DOI:<a href=https://doi.org/10.1177/23259582241255171>10.1177/23259582241255171</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38751360</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jason Johnson-Peretz</dc:creator>
<dc:creator>Anjeline Onyango</dc:creator>
<dc:creator>Sarah A Gutin</dc:creator>
<dc:creator>Laura Balzer</dc:creator>
<dc:creator>Cecilia Akatukwasa</dc:creator>
<dc:creator>Lawrence Owino</dc:creator>
<dc:creator>Titus M O Arunga</dc:creator>
<dc:creator>Fred Atwine</dc:creator>
<dc:creator>Maya Petersen</dc:creator>
<dc:creator>Moses Kamya</dc:creator>
<dc:creator>James Ayieko</dc:creator>
<dc:creator>Ted Ruel</dc:creator>
<dc:creator>Diane Havlir</dc:creator>
<dc:creator>Carol S Camlin</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>Journal of the International Association of Providers of AIDS Care</dc:source>
<dc:title>Clinical Implications of HIV Treatment and Prevention for Polygamous Families in Kenya and Uganda: "My Co-Wife Is the One Who Used to Encourage Me"</dc:title>
<dc:identifier>pmid:38751360</dc:identifier>
<dc:identifier>pmc:PMC11100383</dc:identifier>
<dc:identifier>doi:10.1177/23259582241255171</dc:identifier>
</item>
<item>
<title>ASCC1 structures and bioinformatics reveal a novel Helix-Clasp-Helix RNA-binding motif linked to a two-histidine phosphodiesterase</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38750793/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with regulating splicing, transcriptional, and translation) and two-histidine phosphodiesterase (PDE) (associated with hydrolysis of cyclic nucleotide phosphate bonds). Germline mutations link loss of ASCC1 function to spinal muscular atrophy with congenital bone fractures 2...</description>
<content:encoded><![CDATA[<div>J Biol Chem. 2024 May 13:107368. doi: 10.1016/j.jbc.2024.107368. Online ahead of print.ABSTRACTActivating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with regulating splicing, transcriptional, and translation) and two-histidine phosphodiesterase (PDE) (associated with hydrolysis of cyclic nucleotide phosphate bonds). Germline mutations link loss of ASCC1 function to spinal muscular atrophy with congenital bone fractures 2 (SMABF2). Herein analysis of The Cancer Genome Atlas (TCGA) suggests ASCC1 RNA overexpression in certain tumors correlates with poor survival, Signatures 29 and 3 mutations, and genetic instability markers. We determined crystal structures of Alvinella pompejana (Ap) ASCC1 and Human (Hs) PDE domain revealing high resolution details and features conserved over 500 million years of evolution. Extending understanding of the KH domain Gly-X-X-Gly sequence motif, we define a novel structural Helix-Clasp-Helix (HCH) nucleotide binding motif and show ASCC1 sequence-specific binding to CGCG-containing RNA. The V-shaped PDE nucleotide binding channel has two His-Φ-Ser/Thr-Φ (HXT) motifs (Φ being hydrophobic) positioned to initiate cyclic phosphate bond hydrolysis. A conserved atypical active-site histidine torsion angle implies a novel PDE substrate. Flexible active site loop and arginine-rich domain linker appear regulatory. Small angle X-ray scattering (SAXS) revealed aligned KH-PDE RNA binding sites with limited flexibility in solution. Quantitative evolutionary bioinformatic analyses of disease and cancer-associated mutations support implied functional roles for RNA binding, phosphodiesterase activity, and regulation. Collective results inform ASCC1 roles in transactivation and alkylation damage responses, its targeting by structure-based inhibitors, and how ASCC1 mutations may impact inherited disease and cancer.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38750793/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38750793</a> | DOI:<a href=https://doi.org/10.1016/j.jbc.2024.107368>10.1016/j.jbc.2024.107368</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38750793</guid>
<pubDate>Thu, 16 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Naga Babu Chinnam</dc:creator>
<dc:creator>Roopa Thapar</dc:creator>
<dc:creator>Andrew S Arvai</dc:creator>
<dc:creator>Altaf H Sarker</dc:creator>
<dc:creator>Jennifer M Soll</dc:creator>
<dc:creator>Tanmoy Paul</dc:creator>
<dc:creator>Aleem Syed</dc:creator>
<dc:creator>Daniel J Rosenberg</dc:creator>
<dc:creator>Michal Hammel</dc:creator>
<dc:creator>Albino Bacolla</dc:creator>
<dc:creator>Panagiotis Katsonis</dc:creator>
<dc:creator>Abhishek Asthana</dc:creator>
<dc:creator>Miaw-Sheue Tsai</dc:creator>
<dc:creator>Ivaylo Ivanov</dc:creator>
<dc:creator>Olivier Lichtarge</dc:creator>
<dc:creator>Robert H Silverman</dc:creator>
<dc:creator>Nima Mosammaparast</dc:creator>
<dc:creator>Susan E Tsutakawa</dc:creator>
<dc:creator>John A Tainer</dc:creator>
<dc:date>2024-05-16</dc:date>
<dc:source>The Journal of biological chemistry</dc:source>
<dc:title>ASCC1 structures and bioinformatics reveal a novel Helix-Clasp-Helix RNA-binding motif linked to a two-histidine phosphodiesterase</dc:title>
<dc:identifier>pmid:38750793</dc:identifier>
<dc:identifier>doi:10.1016/j.jbc.2024.107368</dc:identifier>
</item>
<item>
<title>Temporal multiplexing of perception and memory codes in IT cortex</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38750353/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>A central assumption of neuroscience is that long-term memories are represented by the same brain areas that encode sensory stimuli¹. Neurons in inferotemporal (IT) cortex represent the sensory percept of visual objects using a distributed axis code^(2-4). Whether and how the same IT neural population represents the long-term memory of visual objects remains unclear. Here we examined how familiar faces are encoded in the IT anterior medial face patch (AM), perirhinal face patch (PR) and temporal...</description>
<content:encoded><![CDATA[<div>Nature. 2024 May 15. doi: 10.1038/s41586-024-07349-5. Online ahead of print.ABSTRACTA central assumption of neuroscience is that long-term memories are represented by the same brain areas that encode sensory stimuli1. Neurons in inferotemporal (IT) cortex represent the sensory percept of visual objects using a distributed axis code2-4. Whether and how the same IT neural population represents the long-term memory of visual objects remains unclear. Here we examined how familiar faces are encoded in the IT anterior medial face patch (AM), perirhinal face patch (PR) and temporal pole face patch (TP). In AM and PR we observed that the encoding axis for familiar faces is rotated relative to that for unfamiliar faces at long latency; in TP this memory-related rotation was much weaker. Contrary to previous claims, the relative response magnitude to familiar versus unfamiliar faces was not a stable indicator of familiarity in any patch5-11. The mechanism underlying the memory-related axis change is likely intrinsic to IT cortex, because inactivation of PR did not affect axis change dynamics in AM. Overall, our results suggest that memories of familiar faces are represented in AM and perirhinal cortex by a distinct long-latency code, explaining how the same cell population can encode both the percept and memory of faces.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38750353/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38750353</a> | DOI:<a href=https://doi.org/10.1038/s41586-024-07349-5>10.1038/s41586-024-07349-5</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38750353</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Liang She</dc:creator>
<dc:creator>Marcus K Benna</dc:creator>
<dc:creator>Yuelin Shi</dc:creator>
<dc:creator>Stefano Fusi</dc:creator>
<dc:creator>Doris Y Tsao</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Nature</dc:source>
<dc:title>Temporal multiplexing of perception and memory codes in IT cortex</dc:title>
<dc:identifier>pmid:38750353</dc:identifier>
<dc:identifier>doi:10.1038/s41586-024-07349-5</dc:identifier>
</item>
<item>
<title>Late-stage benzenoid-to-troponoid skeletal modification of the cephalotanes exemplified by the total synthesis of harringtonolide</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38750061/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Skeletal modifications enable elegant and rapid access to various derivatives of a compound that would otherwise be difficult to prepare. They are therefore a powerful tool, especially in the synthesis of natural products or drug discovery, to explore different natural products or to improve the properties of a drug candidate starting from a common intermediate. Inspired by the biosynthesis of the cephalotane natural products, we report here a single-atom insertion into the framework of the...</description>
<content:encoded><![CDATA[<div>Nat Commun. 2024 May 15;15(1):4125. doi: 10.1038/s41467-024-48586-6.ABSTRACTSkeletal modifications enable elegant and rapid access to various derivatives of a compound that would otherwise be difficult to prepare. They are therefore a powerful tool, especially in the synthesis of natural products or drug discovery, to explore different natural products or to improve the properties of a drug candidate starting from a common intermediate. Inspired by the biosynthesis of the cephalotane natural products, we report here a single-atom insertion into the framework of the benzenoid subfamily, providing access to the troponoid congeners - representing the reverse of the proposed biosynthesis (i.e., a contra-biosynthesis approach). Computational evaluation of our designed transformation prompted us to investigate a Büchner-Curtius-Schlotterbeck reaction of a p-quinol methylether, which ultimately results in the synthesis of harringtonolide in two steps from cephanolide A, which we had previously prepared. Additional computational studies reveal that unconventional selectivity outcomes are driven by the choice of a Lewis acid and the nucleophile, which should inform further developments of these types of reactions.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38750061/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38750061</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11096412/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11096412</a> | DOI:<a href=https://doi.org/10.1038/s41467-024-48586-6>10.1038/s41467-024-48586-6</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38750061</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Stefan Wiesler</dc:creator>
<dc:creator>Goh Sennari</dc:creator>
<dc:creator>Mihai V Popescu</dc:creator>
<dc:creator>Kristen E Gardner</dc:creator>
<dc:creator>Kazuhiro Aida</dc:creator>
<dc:creator>Robert S Paton</dc:creator>
<dc:creator>Richmond Sarpong</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Nature communications</dc:source>
<dc:title>Late-stage benzenoid-to-troponoid skeletal modification of the cephalotanes exemplified by the total synthesis of harringtonolide</dc:title>
<dc:identifier>pmid:38750061</dc:identifier>
<dc:identifier>pmc:PMC11096412</dc:identifier>
<dc:identifier>doi:10.1038/s41467-024-48586-6</dc:identifier>
</item>
<item>
<title>Effects of indoor air pollution from household solid fuel use on the risk of gastrointestinal and liver diseases in middle aged and elderly adults</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38749122/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Solid fuels are widely used in China and increase the concentrations of indoor air pollutants. Nevertheless, there is limited longitudinal evidence linking solid fuel use and Gastrointestinal (GI) and liver diseases. This study aimed to prospectively investigate the association between household solid fuel use and the risk of GI and liver diseases in middle aged and elderly adults. This work was based on the China Health and Retirement Longitudinal Study (CHARLS). Longitudinal data incorporate...</description>
<content:encoded><![CDATA[<div>Environ Int. 2024 May 10;188:108738. doi: 10.1016/j.envint.2024.108738. Online ahead of print.ABSTRACTSolid fuels are widely used in China and increase the concentrations of indoor air pollutants. Nevertheless, there is limited longitudinal evidence linking solid fuel use and Gastrointestinal (GI) and liver diseases. This study aimed to prospectively investigate the association between household solid fuel use and the risk of GI and liver diseases in middle aged and elderly adults. This work was based on the China Health and Retirement Longitudinal Study (CHARLS). Longitudinal data incorporate with cross-sectional data were analyzed. Compared with individuals using clean fuel for cooking, solid fuel users were observed to have higher risk of GI diseases (OR in 2011, 2013, 2015, 2018 wave separately: 1.37, 95 % CI: 1.24-1.50, P < 0.001; 1.24, 95 % CI: 1.11-1.39, P < 0.001; 1.18, 95 % CI: 1.06-1.33, P < 0.001; 1.23, 95 % CI: 1.04-1.45, P < 0.05). The associations between solid fuel use and liver diseases were not significant in most of the groups. Participants transforming from solid to clean cooking fuels had lower risk of GI and liver diseases than persistent solid fuel users. Moreover, biomass cooking fuel users were at a significant higher risk of both liver and GI diseases compared with clean fuel users. Overall, household solid fuel use, especially for cooking, was related to higher risk of GI and liver diseases, while switching from solid to clean fuels could reduce this risk. Using biomass for cooking was identified to be more associated with the increasing risk of GI and liver diseases than cooking with coal.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38749122/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38749122</a> | DOI:<a href=https://doi.org/10.1016/j.envint.2024.108738>10.1016/j.envint.2024.108738</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38749122</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Danrong Chen</dc:creator>
<dc:creator>Hongcheng Wei</dc:creator>
<dc:creator>Yuepei Zhang</dc:creator>
<dc:creator>Xu Yang</dc:creator>
<dc:creator>Yifan Xu</dc:creator>
<dc:creator>Quanquan Guan</dc:creator>
<dc:creator>Mingzhi Zhang</dc:creator>
<dc:creator>Bo Hang</dc:creator>
<dc:creator>Yankai Xia</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Environment international</dc:source>
<dc:title>Effects of indoor air pollution from household solid fuel use on the risk of gastrointestinal and liver diseases in middle aged and elderly adults</dc:title>
<dc:identifier>pmid:38749122</dc:identifier>
<dc:identifier>doi:10.1016/j.envint.2024.108738</dc:identifier>
</item>
<item>
<title>Nature and human well-being: The olfactory pathway</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38748806/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The world is undergoing massive atmospheric and ecological change, driving unprecedented challenges to human well-being. Olfaction is a key sensory system through which these impacts occur. The sense of smell influences quality of and satisfaction with life, emotion, emotion regulation, cognitive function, social interactions, dietary choices, stress, and depressive symptoms. Exposures via the olfactory pathway can also lead to (anti-)inflammatory outcomes. Increased understanding is needed...</description>
<content:encoded><![CDATA[<div>Sci Adv. 2024 May 17;10(20):eadn3028. doi: 10.1126/sciadv.adn3028. Epub 2024 May 15.ABSTRACTThe world is undergoing massive atmospheric and ecological change, driving unprecedented challenges to human well-being. Olfaction is a key sensory system through which these impacts occur. The sense of smell influences quality of and satisfaction with life, emotion, emotion regulation, cognitive function, social interactions, dietary choices, stress, and depressive symptoms. Exposures via the olfactory pathway can also lead to (anti-)inflammatory outcomes. Increased understanding is needed regarding the ways in which odorants generated by nature (i.e., natural olfactory environments) affect human well-being. With perspectives from a range of health, social, and natural sciences, we provide an overview of this unique sensory system, four consensus statements regarding olfaction and the environment, and a conceptual framework that integrates the olfactory pathway into an understanding of the effects of natural environments on human well-being. We then discuss how this framework can contribute to better accounting of the impacts of policy and land-use decision-making on natural olfactory environments and, in turn, on planetary health.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38748806/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38748806</a> | DOI:<a href=https://doi.org/10.1126/sciadv.adn3028>10.1126/sciadv.adn3028</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38748806</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Gregory N Bratman</dc:creator>
<dc:creator>Cecilia Bembibre</dc:creator>
<dc:creator>Gretchen C Daily</dc:creator>
<dc:creator>Richard L Doty</dc:creator>
<dc:creator>Thomas Hummel</dc:creator>
<dc:creator>Lucia F Jacobs</dc:creator>
<dc:creator>Peter H Kahn</dc:creator>
<dc:creator>Connor Lashus</dc:creator>
<dc:creator>Asifa Majid</dc:creator>
<dc:creator>John D Miller</dc:creator>
<dc:creator>Anna Oleszkiewicz</dc:creator>
<dc:creator>Hector Olvera-Alvarez</dc:creator>
<dc:creator>Valentina Parma</dc:creator>
<dc:creator>Anne M Riederer</dc:creator>
<dc:creator>Nancy Long Sieber</dc:creator>
<dc:creator>Jonathan Williams</dc:creator>
<dc:creator>Jieling Xiao</dc:creator>
<dc:creator>Chia-Pin Yu</dc:creator>
<dc:creator>John D Spengler</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Science advances</dc:source>
<dc:title>Nature and human well-being: The olfactory pathway</dc:title>
<dc:identifier>pmid:38748806</dc:identifier>
<dc:identifier>doi:10.1126/sciadv.adn3028</dc:identifier>
</item>
<item>
<title>Artificial neural networks for model identification and parameter estimation in computational cognitive models</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38748770/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Computational cognitive models have been used extensively to formalize cognitive processes. Model parameters offer a simple way to quantify individual differences in how humans process information. Similarly, model comparison allows researchers to identify which theories, embedded in different models, provide the best accounts of the data. Cognitive modeling uses statistical tools to quantitatively relate models to data that often rely on computing/estimating the likelihood of the data under the...</description>
<content:encoded><![CDATA[<div>PLoS Comput Biol. 2024 May 15;20(5):e1012119. doi: 10.1371/journal.pcbi.1012119. Online ahead of print.ABSTRACTComputational cognitive models have been used extensively to formalize cognitive processes. Model parameters offer a simple way to quantify individual differences in how humans process information. Similarly, model comparison allows researchers to identify which theories, embedded in different models, provide the best accounts of the data. Cognitive modeling uses statistical tools to quantitatively relate models to data that often rely on computing/estimating the likelihood of the data under the model. However, this likelihood is computationally intractable for a substantial number of models. These relevant models may embody reasonable theories of cognition, but are often under-explored due to the limited range of tools available to relate them to data. We contribute to filling this gap in a simple way using artificial neural networks (ANNs) to map data directly onto model identity and parameters, bypassing the likelihood estimation. We test our instantiation of an ANN as a cognitive model fitting tool on classes of cognitive models with strong inter-trial dependencies (such as reinforcement learning models), which offer unique challenges to most methods. We show that we can adequately perform both parameter estimation and model identification using our ANN approach, including for models that cannot be fit using traditional likelihood-based methods. We further discuss our work in the context of the ongoing research leveraging simulation-based approaches to parameter estimation and model identification, and how these approaches broaden the class of cognitive models researchers can quantitatively investigate.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38748770/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38748770</a> | DOI:<a href=https://doi.org/10.1371/journal.pcbi.1012119>10.1371/journal.pcbi.1012119</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38748770</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Milena Rmus</dc:creator>
<dc:creator>Ti-Fen Pan</dc:creator>
<dc:creator>Liyu Xia</dc:creator>
<dc:creator>Anne G E Collins</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>PLoS computational biology</dc:source>
<dc:title>Artificial neural networks for model identification and parameter estimation in computational cognitive models</dc:title>
<dc:identifier>pmid:38748770</dc:identifier>
<dc:identifier>doi:10.1371/journal.pcbi.1012119</dc:identifier>
</item>
<item>
<title>Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38748589/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The highly conserved angiosperm immune receptor HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) is a bacterial pathogen recognition hub that mediates resistance by guarding host kinases for modification by pathogen effectors. The pseudokinase HOPZ-ETI DEFICIENT 1 (ZED1) is the only known ZAR1-guarded protein that interacts directly with a pathogen effector, HopZ1a, from the bacterial pathogen Pseudomonas syringae, making it a promising system for rational design of effector recognition for plant immunity....</description>
<content:encoded><![CDATA[<div>Plant Physiol. 2024 May 15:kiae268. doi: 10.1093/plphys/kiae268. Online ahead of print.ABSTRACTThe highly conserved angiosperm immune receptor HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) is a bacterial pathogen recognition hub that mediates resistance by guarding host kinases for modification by pathogen effectors. The pseudokinase HOPZ-ETI DEFICIENT 1 (ZED1) is the only known ZAR1-guarded protein that interacts directly with a pathogen effector, HopZ1a, from the bacterial pathogen Pseudomonas syringae, making it a promising system for rational design of effector recognition for plant immunity. Here, we conducted an in-depth molecular analysis of ZED1. We generated a library of 164 random ZED1 mutants and identified 50 mutants that could not recognize the effector HopZ1a when transiently expressed in Nicotiana benthamiana. Based on our random mutants, we generated a library of 27 point mutants and found evidence of minor functional divergence between Arabidopsis (Arabidopsis thaliana) and N. benthamiana ZAR1 orthologs. We leveraged our point mutant library to identify regions in ZED1 critical for ZAR1 and HopZ1a interactions and identified two likely ZED1-HopZ1a binding conformations. We explored ZED1 nucleotide and cation binding activity and showed that ZED1 is a catalytically dead pseudokinase, functioning solely as an allosteric regulator upon effector recognition. We used our library of ZED1 point mutants to identify the ZED1 activation loop regions as the most likely cause of interspecies ZAR1-ZED1 incompatibility. Finally, we identified a mutation that abolished ZAR1-ZED1 interspecies incompatibility while retaining the ability to mediate HopZ1a recognition, which enabled recognition of HopZ1a through tomato (Solanum lycopersicum) ZAR1. This provides an example of expanded effector recognition through a ZAR1 ortholog from a non-model species.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38748589/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38748589</a> | DOI:<a href=https://doi.org/10.1093/plphys/kiae268>10.1093/plphys/kiae268</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38748589</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Nathan Diplock</dc:creator>
<dc:creator>Maël Baudin</dc:creator>
<dc:creator>Derek Xiang</dc:creator>
<dc:creator>Lung-Yu Liang</dc:creator>
<dc:creator>Weiwen Dai</dc:creator>
<dc:creator>James M Murphy</dc:creator>
<dc:creator>Isabelle S Lucet</dc:creator>
<dc:creator>Jana A Hassan</dc:creator>
<dc:creator>Jennifer D Lewis</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Plant physiology</dc:source>
<dc:title>Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1</dc:title>
<dc:identifier>pmid:38748589</dc:identifier>
<dc:identifier>doi:10.1093/plphys/kiae268</dc:identifier>
</item>
<item>
<title>Porous Nanographenes, Graphene Nanoribbons, and Nanoporous Graphene Selectively Synthesized from the Same Molecular Precursor</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747845/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>We demonstrate a family of molecular precursors based on 7,10-dibromo-triphenylenes that can selectively produce different varieties of atomically precise porous graphene nanomaterials through the use of different synthetic environments. Upon Yamamoto polymerization of these molecules in solution, the free rotations of the triphenylene units around the C-C bonds result in the formation of cyclotrimers in high yields. In contrast, in on-surface polymerization of the same molecules on Au(111)...</description>
<content:encoded><![CDATA[<div>J Am Chem Soc. 2024 May 15. doi: 10.1021/jacs.3c10842. Online ahead of print.ABSTRACTWe demonstrate a family of molecular precursors based on 7,10-dibromo-triphenylenes that can selectively produce different varieties of atomically precise porous graphene nanomaterials through the use of different synthetic environments. Upon Yamamoto polymerization of these molecules in solution, the free rotations of the triphenylene units around the C-C bonds result in the formation of cyclotrimers in high yields. In contrast, in on-surface polymerization of the same molecules on Au(111) these rotations are impeded, and the coupling proceeds toward the formation of long polymer chains. These chains can then be converted to porous graphene nanoribbons (pGNRs) by annealing. Correspondingly, the solution-synthesized cyclotrimers can also be deposited onto Au(111) and converted into porous nanographenes (pNGs) via thermal treatment. Thus, both processes start with the same molecular precursor and end with a porous graphene nanomaterial on Au(111), but the type of product, pNG or pGNR, depends on the specific coupling approach. We also produced extended nanoporous graphenes (NPGs) through the lateral fusion of highly aligned pGNRs on Au(111) that were grown at high coverage. The pNGs can also be synthesized directly in solution by Scholl oxidative cyclodehydrogenation of cyclotrimers. We demonstrate the generality of this approach by synthesizing two varieties of 7,10-dibromo-triphenylenes that selectively produced six nanoporous products with different dimensionalities. The basic 7,10-dibromo-triphenylene monomer is amenable to structural modifications, potentially providing access to many new porous graphene nanomaterials. We show that by constructing different porous structures from the same building blocks, it is possible to tune the energy band gap in a wide range.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747845/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747845</a> | DOI:<a href=https://doi.org/10.1021/jacs.3c10842>10.1021/jacs.3c10842</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747845</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Mamun Sarker</dc:creator>
<dc:creator>Christoph Dobner</dc:creator>
<dc:creator>Percy Zahl</dc:creator>
<dc:creator>Christian Fiankor</dc:creator>
<dc:creator>Jian Zhang</dc:creator>
<dc:creator>Anshul Saxena</dc:creator>
<dc:creator>Narayana Aluru</dc:creator>
<dc:creator>Axel Enders</dc:creator>
<dc:creator>Alexander Sinitskii</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Journal of the American Chemical Society</dc:source>
<dc:title>Porous Nanographenes, Graphene Nanoribbons, and Nanoporous Graphene Selectively Synthesized from the Same Molecular Precursor</dc:title>
<dc:identifier>pmid:38747845</dc:identifier>
<dc:identifier>doi:10.1021/jacs.3c10842</dc:identifier>
</item>
<item>
<title>Interface Effects in the Stability of 2D Silica, Silicide, and Silicene on Pt(111) and Rh(111)</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747629/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Ultrathin two-dimensional silica films have been suggested as highly defined conductive models for fundamental studies on silica-supported catalyst particles. Key requirements in this context are closed silica films that isolate the gas phase from the underlying metal substrate and stability under reaction conditions. Here, we present silica bilayer films grown on Pt(111) and Rh(111) and characterize them by scanning tunneling microscopy and X-ray photoelectron spectroscopy. We provide the first...</description>
<content:encoded><![CDATA[<div>ACS Appl Mater Interfaces. 2024 May 15. doi: 10.1021/acsami.4c05137. Online ahead of print.ABSTRACTUltrathin two-dimensional silica films have been suggested as highly defined conductive models for fundamental studies on silica-supported catalyst particles. Key requirements in this context are closed silica films that isolate the gas phase from the underlying metal substrate and stability under reaction conditions. Here, we present silica bilayer films grown on Pt(111) and Rh(111) and characterize them by scanning tunneling microscopy and X-ray photoelectron spectroscopy. We provide the first report of silica bilayer films on Rh(111) and have further successfully prepared fully closed films on Pt(111). Interestingly, surface and interface silicide phases play a decisive role in both cases: On platinum, closed films can be stabilized only when silicon is deposited in excess, which results in an interfacial silicide or silicate layer. We show that these silica films can also be grown directly from a surface silicide phase. In the case of rhodium, the silica phase is less stable and can be reduced to a silicide in reductive environments. Though similar in appearance to the "silicene" phases that have been controversially discussed on Ag(111), we conclude that an interpretation of the phase as a surface silicide is more consistent with our data. Finally, we show that the silica film on platinum is stable in 0.8 mbar CO but unstable at elevated temperatures. We thus conclude that these systems are only suitable as model catalyst supports to a limited extent.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747629/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747629</a> | DOI:<a href=https://doi.org/10.1021/acsami.4c05137>10.1021/acsami.4c05137</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747629</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Matthias Krinninger</dc:creator>
<dc:creator>Florian Kraushofer</dc:creator>
<dc:creator>Nils B Refvik</dc:creator>
<dc:creator>Monika Blum</dc:creator>
<dc:creator>Barbara A J Lechner</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>ACS applied materials & interfaces</dc:source>
<dc:title>Interface Effects in the Stability of 2D Silica, Silicide, and Silicene on Pt(111) and Rh(111)</dc:title>
<dc:identifier>pmid:38747629</dc:identifier>
<dc:identifier>doi:10.1021/acsami.4c05137</dc:identifier>
</item>
<item>
<title>Building momentum through networks: Bioimaging across the Americas</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747464/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>In September 2023, the two largest bioimaging networks in the Americas, Latin America Bioimaging (LABI) and BioImaging North America (BINA), came together during a 1-week meeting in Mexico. This meeting provided opportunities for participants to interact closely with decision-makers from imaging core facilities across the Americas. The meeting was held in a hybrid format and attended in-person by imaging scientists from across the Americas, including Canada, the United States, Mexico, Colombia,...</description>
<content:encoded><![CDATA[<div>J Microsc. 2024 May 15. doi: 10.1111/jmi.13318. Online ahead of print.ABSTRACTIn September 2023, the two largest bioimaging networks in the Americas, Latin America Bioimaging (LABI) and BioImaging North America (BINA), came together during a 1-week meeting in Mexico. This meeting provided opportunities for participants to interact closely with decision-makers from imaging core facilities across the Americas. The meeting was held in a hybrid format and attended in-person by imaging scientists from across the Americas, including Canada, the United States, Mexico, Colombia, Peru, Argentina, Chile, Brazil and Uruguay. The aims of the meeting were to discuss progress achieved over the past year, to foster networking and collaborative efforts among members of both communities, to bring together key members of the international imaging community to promote the exchange of experience and expertise, to engage with industry partners, and to establish future directions within each individual network, as well as common goals. This meeting report summarises the discussions exchanged, the achievements shared, and the goals set during the LABIxBINA2023: Bioimaging across the Americas meeting.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747464/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747464</a> | DOI:<a href=https://doi.org/10.1111/jmi.13318>10.1111/jmi.13318</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747464</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Mariana De Niz</dc:creator>
<dc:creator>Rodrigo Escobedo García</dc:creator>
<dc:creator>Celina Terán Ramirez</dc:creator>
<dc:creator>Ysa Pakowski</dc:creator>
<dc:creator>Yuriney Abonza</dc:creator>
<dc:creator>Nikki Bialy</dc:creator>
<dc:creator>Vanessa L Orr</dc:creator>
<dc:creator>Andres Olivera</dc:creator>
<dc:creator>Victor Abonza</dc:creator>
<dc:creator>Karina Alleva</dc:creator>
<dc:creator>Silvana Allodi</dc:creator>
<dc:creator>Michael F Almeida</dc:creator>
<dc:creator>Alexis Ricardo Becerril Cuevas</dc:creator>
<dc:creator>Frederic Bonnet</dc:creator>
<dc:creator>Armando Burgos Solorio</dc:creator>
<dc:creator>Teng-Leong Chew</dc:creator>
<dc:creator>Gustavo Chiabrando</dc:creator>
<dc:creator>Beth Cimini</dc:creator>
<dc:creator>Aurélie Cleret-Buhot</dc:creator>
<dc:creator>Gastón Contreras Jiménez</dc:creator>
<dc:creator>Laura Daza</dc:creator>
<dc:creator>Vanessa De Sá</dc:creator>
<dc:creator>Natalia De Val</dc:creator>
<dc:creator>Diego L Delgado-Álvarez</dc:creator>
<dc:creator>Kevin Eliceiri</dc:creator>
<dc:creator>Reto Fiolka</dc:creator>
<dc:creator>Hernan Grecco</dc:creator>
<dc:creator>Dorit Hanein</dc:creator>
<dc:creator>Paúl Hernández Herrera</dc:creator>
<dc:creator>Phil Hockberger</dc:creator>
<dc:creator>Haydee O Hernandez</dc:creator>
<dc:creator>Yael Hernandez Guadarrama</dc:creator>
<dc:creator>Michelle Itano</dc:creator>
<dc:creator>Caron A Jacobs</dc:creator>
<dc:creator>Luis F Jiménez-García</dc:creator>
<dc:creator>Vilma Jiménez Sabinina</dc:creator>
<dc:creator>Andres Kamaid</dc:creator>
<dc:creator>Antje Keppler</dc:creator>
<dc:creator>Abhishek Kumar</dc:creator>
<dc:creator>Judith Lacoste</dc:creator>
<dc:creator>Alenka Lovy</dc:creator>
<dc:creator>Kate Luby-Phelps</dc:creator>
<dc:creator>Anita Mahadevan-Jansen</dc:creator>
<dc:creator>Leonel Malacrida</dc:creator>
<dc:creator>Shalin B Mehta</dc:creator>
<dc:creator>Caroline Miller</dc:creator>
<dc:creator>Kildare Miranda</dc:creator>
<dc:creator>Joshua A Moore</dc:creator>
<dc:creator>Alison North</dc:creator>
<dc:creator>Peter O'Toole</dc:creator>
<dc:creator>Mariana Olivares Urbano</dc:creator>
<dc:creator>Lía I Pietrasanta</dc:creator>
<dc:creator>Rodrigo V Portugal</dc:creator>
<dc:creator>Andrés H Rossi</dc:creator>
<dc:creator>Jonathan Sanchez Contreras</dc:creator>
<dc:creator>Caterina Strambio-De-Castilla</dc:creator>
<dc:creator>Gloria Soldevila</dc:creator>
<dc:creator>Bruno Vale</dc:creator>
<dc:creator>Diana Vazquez</dc:creator>
<dc:creator>Chris Wood</dc:creator>
<dc:creator>Claire M Brown</dc:creator>
<dc:creator>Adan Guerrero</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Journal of microscopy</dc:source>
<dc:title>Building momentum through networks: Bioimaging across the Americas</dc:title>
<dc:identifier>pmid:38747464</dc:identifier>
<dc:identifier>doi:10.1111/jmi.13318</dc:identifier>
</item>
<item>
<title>The importance of input sequence set to consensus-derived proteins and their relationship to reconstructed ancestral proteins</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747388/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>A protein sequence encodes its energy landscape-all the accessible conformations, energetics, and dynamics. The evolutionary relationship between sequence and landscape can be probed phylogenetically by compiling a multiple sequence alignment of homologous sequences and generating common ancestors via Ancestral Sequence Reconstruction or a consensus protein containing the most common amino acid at each position. Both ancestral and consensus proteins are often more stable than their extant...</description>
<content:encoded><![CDATA[<div>Protein Sci. 2024 Jun;33(6):e5011. doi: 10.1002/pro.5011.ABSTRACTA protein sequence encodes its energy landscape-all the accessible conformations, energetics, and dynamics. The evolutionary relationship between sequence and landscape can be probed phylogenetically by compiling a multiple sequence alignment of homologous sequences and generating common ancestors via Ancestral Sequence Reconstruction or a consensus protein containing the most common amino acid at each position. Both ancestral and consensus proteins are often more stable than their extant homologs-questioning the differences between them and suggesting that both approaches serve as general methods to engineer thermostability. We used the Ribonuclease H family to compare these approaches and evaluate how the evolutionary relationship of the input sequences affects the properties of the resulting consensus protein. While the consensus protein derived from our full Ribonuclease H sequence alignment is structured and active, it neither shows properties of a well-folded protein nor has enhanced stability. In contrast, the consensus protein derived from a phylogenetically-restricted set of sequences is significantly more stable and cooperatively folded, suggesting that cooperativity may be encoded by different mechanisms in separate clades and lost when too many diverse clades are combined to generate a consensus protein. To explore this, we compared pairwise covariance scores using a Potts formalism as well as higher-order sequence correlations using singular value decomposition (SVD). We find the SVD coordinates of a stable consensus sequence are close to coordinates of the analogous ancestor sequence and its descendants, whereas the unstable consensus sequences are outliers in SVD space.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747388/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747388</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11094778/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11094778</a> | DOI:<a href=https://doi.org/10.1002/pro.5011>10.1002/pro.5011</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747388</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Charlotte Nixon</dc:creator>
<dc:creator>Shion A Lim</dc:creator>
<dc:creator>Matt Sternke</dc:creator>
<dc:creator>Doug Barrick</dc:creator>
<dc:creator>Michael J Harms</dc:creator>
<dc:creator>Susan Marqusee</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Protein science : a publication of the Protein Society</dc:source>
<dc:title>The importance of input sequence set to consensus-derived proteins and their relationship to reconstructed ancestral proteins</dc:title>
<dc:identifier>pmid:38747388</dc:identifier>
<dc:identifier>pmc:PMC11094778</dc:identifier>
<dc:identifier>doi:10.1002/pro.5011</dc:identifier>
</item>
<item>
<title>Warming effects on grassland soil microbial communities are amplified in cool months</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747385/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Global warming modulates soil respiration (RS) via microbial decomposition, which is seasonally dependent. Yet, the magnitude and direction of this modulation remain unclear, partly owing to the lack of knowledge on how microorganisms respond to seasonal changes. Here, we investigated the temporal dynamics of soil microbial communities over 12 consecutive months under experimental warming in a tallgrass prairie ecosystem. The interplay between warming and time altered (p < 0.05) the taxonomic...</description>
<content:encoded><![CDATA[<div>ISME J. 2024 May 15:wrae088. doi: 10.1093/ismejo/wrae088. Online ahead of print.ABSTRACTGlobal warming modulates soil respiration (RS) via microbial decomposition, which is seasonally dependent. Yet, the magnitude and direction of this modulation remain unclear, partly owing to the lack of knowledge on how microorganisms respond to seasonal changes. Here, we investigated the temporal dynamics of soil microbial communities over 12 consecutive months under experimental warming in a tallgrass prairie ecosystem. The interplay between warming and time altered (p < 0.05) the taxonomic and functional compositions of microbial communities. During the cool months (January to February and October to December), warming induced a soil microbiome with a higher genomic potential for carbon decomposition, community-level ribosomal RNA operon (rrn) copy numbers, and microbial metabolic quotients, suggesting that warming stimulated fast-growing microorganisms that enhanced carbon decomposition. Modeling analyses further showed that warming reduced the temperature sensitivity of microbial carbon use efficiency (CUE) by 28.7% when monthly average temperature was low, resulting in lower microbial CUE and higher heterotrophic respiration (Rh) potentials. Structural equation modeling showed that warming modulated both Rh and RS directly by altering soil temperature and indirectly by influencing microbial community traits, soil moisture, nitrate content, soil pH, and gross primary productivity. The modulation of Rh by warming was more pronounced in cooler months compared to warmer ones. Together, our findings reveal distinct warming-induced effects on microbial functional traits in cool months, challenging the norm of soil sampling only in the peak growing season, and advancing our mechanistic understanding of the seasonal pattern of RS and Rh sensitivity to warming.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747385/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747385</a> | DOI:<a href=https://doi.org/10.1093/ismejo/wrae088>10.1093/ismejo/wrae088</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747385</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jiesi Lei</dc:creator>
<dc:creator>Yuanlong Su</dc:creator>
<dc:creator>Siyang Jian</dc:creator>
<dc:creator>Xue Guo</dc:creator>
<dc:creator>Mengting Yuan</dc:creator>
<dc:creator>Colin T Bates</dc:creator>
<dc:creator>Zhou Jason Shi</dc:creator>
<dc:creator>Jiabao Li</dc:creator>
<dc:creator>Yifan Su</dc:creator>
<dc:creator>Daliang Ning</dc:creator>
<dc:creator>Liyou Wu</dc:creator>
<dc:creator>Jizhong Zhou</dc:creator>
<dc:creator>Yunfeng Yang</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>The ISME journal</dc:source>
<dc:title>Warming effects on grassland soil microbial communities are amplified in cool months</dc:title>
<dc:identifier>pmid:38747385</dc:identifier>
<dc:identifier>doi:10.1093/ismejo/wrae088</dc:identifier>
</item>
<item>
<title>Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747383/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The Sec61 translocon allows the translocation of secretory preproteins from the cytosol to the endoplasmic reticulum lumen during polypeptide biosynthesis. These proteins possess an N-terminal signal peptide (SP) which docks at the translocon. SP mutations can abolish translocation and cause diseases, suggesting an essential role for this SP/Sec61 interaction. However, a detailed biophysical characterization of this binding is still missing. Here, optical tweezers force spectroscopy was used to...</description>
<content:encoded><![CDATA[<div>Protein Sci. 2024 Jun;33(6):e4996. doi: 10.1002/pro.4996.ABSTRACTThe Sec61 translocon allows the translocation of secretory preproteins from the cytosol to the endoplasmic reticulum lumen during polypeptide biosynthesis. These proteins possess an N-terminal signal peptide (SP) which docks at the translocon. SP mutations can abolish translocation and cause diseases, suggesting an essential role for this SP/Sec61 interaction. However, a detailed biophysical characterization of this binding is still missing. Here, optical tweezers force spectroscopy was used to characterize the kinetic parameters of the dissociation process between Sec61 and the SP of prepro-alpha-factor. The unbinding parameters including off-rate constant and distance to the transition state were obtained by fitting rupture force data to Dudko-Hummer-Szabo models. Interestingly, the translocation inhibitor mycolactone increases the off-rate and accelerates the SP/Sec61 dissociation, while also weakening the interaction. Whereas the translocation deficient mutant containing a single point mutation in the SP abolished the specificity of the SP/Sec61 binding, resulting in an unstable interaction. In conclusion, we characterize quantitatively the dissociation process between the signal peptide and the translocon, and how the unbinding parameters are modified by a translocation inhibitor.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747383/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747383</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11094780/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11094780</a> | DOI:<a href=https://doi.org/10.1002/pro.4996>10.1002/pro.4996</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747383</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Luka Robeson</dc:creator>
<dc:creator>Nathalie Casanova-Morales</dc:creator>
<dc:creator>Francesca Burgos-Bravo</dc:creator>
<dc:creator>Hilda M Alfaro-Valdés</dc:creator>
<dc:creator>Robert Lesch</dc:creator>
<dc:creator>Carolina Ramírez-Álvarez</dc:creator>
<dc:creator>Mauricio Valdivia-Delgado</dc:creator>
<dc:creator>Marcela Vega</dc:creator>
<dc:creator>Ricardo A Matute</dc:creator>
<dc:creator>Randy Schekman</dc:creator>
<dc:creator>Christian A M Wilson</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Protein science : a publication of the Protein Society</dc:source>
<dc:title>Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers</dc:title>
<dc:identifier>pmid:38747383</dc:identifier>
<dc:identifier>pmc:PMC11094780</dc:identifier>
<dc:identifier>doi:10.1002/pro.4996</dc:identifier>
</item>
<item>
<title>Spontaneous Particle Ordering, Sorting, and Assembly on Soap Films</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747334/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Soap bubbles exhibit abundant fascinating phenomena throughout the entire life of evolution with different fundamental physics governing them. Nevertheless, the complicated dynamics of small objects in soap films are still unrevealed. Here, we report the first observation of spontaneous particle ordering in a complicated galaxy of soap films without any external energy. The balance of interfacial tension at two liquid-gas interfaces is theoretically predicted to govern belted wetted particles...</description>
<content:encoded><![CDATA[<div>Nano Lett. 2024 May 15. doi: 10.1021/acs.nanolett.4c01840. Online ahead of print.ABSTRACTSoap bubbles exhibit abundant fascinating phenomena throughout the entire life of evolution with different fundamental physics governing them. Nevertheless, the complicated dynamics of small objects in soap films are still unrevealed. Here, we report the first observation of spontaneous particle ordering in a complicated galaxy of soap films without any external energy. The balance of interfacial tension at two liquid-gas interfaces is theoretically predicted to govern belted wetted particles (BWPs) traveling along a specified path spontaneously. Such spontaneous particle path-finding is found to depend on the particle size and hydrophilic properties. Spontaneous particle sorting is directly realized via these discrete and distinctive paths for different particles. The deformation of the soap membrane facilitates 1D/2D particle organization along the path. This observation represents the discovery of a new spontaneous order phenomenon in soap film systems and provides a new energy-free approach for particle separation and soft colloidal crystal assembly.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747334/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747334</a> | DOI:<a href=https://doi.org/10.1021/acs.nanolett.4c01840>10.1021/acs.nanolett.4c01840</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747334</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Yang Shi</dc:creator>
<dc:creator>Danning Wang</dc:creator>
<dc:creator>Yuqing Xiao</dc:creator>
<dc:creator>Ting Pan</dc:creator>
<dc:creator>Wenpeng Liu</dc:creator>
<dc:creator>Luke P Lee</dc:creator>
<dc:creator>Hongbao Xin</dc:creator>
<dc:creator>Baojun Li</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Nano letters</dc:source>
<dc:title>Spontaneous Particle Ordering, Sorting, and Assembly on Soap Films</dc:title>
<dc:identifier>pmid:38747334</dc:identifier>
<dc:identifier>doi:10.1021/acs.nanolett.4c01840</dc:identifier>
</item>
<item>
<title>Cognitive Trajectories and Alzheimer Disease Biomarkers: From Successful Cognitive Aging to Clinical Impairment</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747315/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>OBJECTIVE: Cross-sectional definitions of successful cognitive aging have been widely utilized, but longitudinal measurements can identify people who do not decline. We performed this study to contrast maintenance with declining trajectories, including clinical conversion.</description>
<content:encoded><![CDATA[<div>Ann Neurol. 2024 May 15. doi: 10.1002/ana.26964. Online ahead of print.ABSTRACTOBJECTIVE: Cross-sectional definitions of successful cognitive aging have been widely utilized, but longitudinal measurements can identify people who do not decline. We performed this study to contrast maintenance with declining trajectories, including clinical conversion.METHODS: We included baseline cognitively unimpaired Alzheimer's Disease Neuroimaging Initiative participants with 3 or more cognitive testing sessions (n = 539, follow-up 6.1 ± 3.5 years) and calculated slopes of an episodic memory composite (MEM) to classify them into two groups: maintainers (slope ≥ 0) and decliners (slope < 0). Within decliners, we examined a subgroup of individuals who became clinically impaired during follow-up. These groups were compared on baseline characteristics and cognitive performance, as well as both cross-sectional and longitudinal Alzheimer disease (AD) biomarker measures (beta-amyloid [Aβ], tau, and hippocampal volume).RESULTS: Forty-one percent (n = 221) of the cohort were MEM maintainers, and 33% (n = 105) of decliners converted to clinical impairment during follow-up. Compared to those with superior baseline scores, maintainers had lower education and were more likely to be male. Maintainers and decliners did not differ on baseline MEM scores, but maintainers did have higher non-MEM cognitive scores. Maintainers had lower baseline global Aβ, lower tau pathology, and larger hippocampal volumes than decliners, even after removing converters. There were no differences in rates of change of any AD biomarkers between any cognitive trajectory groups except for a higher rate of hippocampal atrophy in clinical converters compared to maintainers.INTERPRETATION: Using longitudinal data to define cognitive trajectory groups reduces education and sex bias and reveals the prognostic importance of early onset of accumulation of AD pathology. ANN NEUROL 2024.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747315/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747315</a> | DOI:<a href=https://doi.org/10.1002/ana.26964>10.1002/ana.26964</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747315</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Theresa M Harrison</dc:creator>
<dc:creator>Trevor Chadwick</dc:creator>
<dc:creator>Stefania Pezzoli</dc:creator>
<dc:creator>JiaQie Lee</dc:creator>
<dc:creator>Susan M Landau</dc:creator>
<dc:creator>William J Jagust</dc:creator>
<dc:creator>Alzheimer's Disease Neuroimaging Initiative</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Annals of neurology</dc:source>
<dc:title>Cognitive Trajectories and Alzheimer Disease Biomarkers: From Successful Cognitive Aging to Clinical Impairment</dc:title>
<dc:identifier>pmid:38747315</dc:identifier>
<dc:identifier>doi:10.1002/ana.26964</dc:identifier>
</item>
<item>
<title>Reducing Commercial Tobacco Sales to Youth On and Around California Tribal Reservations with a Reward and Reminder Retail Intervention</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38747187/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: The intervention increased awareness of laws prohibiting CTP sales to minors and mandating age verification for young adults seeking to buy CTP. The intervention, which had support from all governing Tribal Nations, builds the evidence base of effective practices which Tribal public health authorities may utilize to reduce youth access to CTP on and around Tribal reservations.</description>
<content:encoded><![CDATA[<div>Nicotine Tob Res. 2024 May 15:ntae110. doi: 10.1093/ntr/ntae110. Online ahead of print.ABSTRACTINTRODUCTION: High prevalence of commercial tobacco product (CTP) use among American Indian and Alaska Native (AI/AN) youth is a public health crisis. A multi-level Tribal-community-based participatory research project under Tribal public health authority implemented a retailer-focused intervention to reduce AI/AN youth CTP use.METHODS: We sought resolutions in support of a retailer-focused CTP intervention from Tribal Nations organized by a tribally-directed research program. We identified tobacco retail outlets operating on and within 5 miles of 9 Tribal reservations, and CTP products sold at these outlets. We conducted a four-wave Reward and Reminder intervention with apparent minor buyers. Clerks who complied with the law received a modest reward and commendation in social media posts to the local Tribal communities, while clerks who sold without age verification were reminded of the laws.RESULTS: Of 18 retail outlets selling CTP, 8 sold e-cigarettes, and all sold combustible cigarettes. The Reward and Reminder intervention showed an approximate 25% reduction in sales of CTP to apparent minors, with a 33% baseline CTP sales rate without age verification and an 8% intervention CTP sales rate without age verification.CONCLUSIONS: The intervention increased awareness of laws prohibiting CTP sales to minors and mandating age verification for young adults seeking to buy CTP. The intervention, which had support from all governing Tribal Nations, builds the evidence base of effective practices which Tribal public health authorities may utilize to reduce youth access to CTP on and around Tribal reservations.IMPLICATIONS: Sovereign Tribes have authority over commercial businesses operating on their lands. Tobacco 21 laws aiming to restrict commercial tobacco availability to youth are supported by Tribes. A retailer intervention in which apparent minors attempt commercial tobacco purchases can offer accountability feedback to retailers both on and near Tribal reservations. Obtaining Tribal support and publicizing the interventions helps mobilize Tribal communities to support commercial tobacco prevention and promote healthy youth.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38747187/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38747187</a> | DOI:<a href=https://doi.org/10.1093/ntr/ntae110>10.1093/ntr/ntae110</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38747187</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Chase Kornacki</dc:creator>
<dc:creator>Joseph Rodriguez</dc:creator>
<dc:creator>Justin Rodriguez</dc:creator>
<dc:creator>Alec J Calac</dc:creator>
<dc:creator>Daniel Calac</dc:creator>
<dc:creator>Juliet Lee</dc:creator>
<dc:creator>Roland Moore</dc:creator>
<dc:creator>Lisa Brucks</dc:creator>
<dc:creator>Isabella Jacques</dc:creator>
<dc:creator>Maxine Yang</dc:creator>
<dc:creator>Veronica Almodovar</dc:creator>
<dc:creator>Samantha Starr Berber</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco</dc:source>
<dc:title>Reducing Commercial Tobacco Sales to Youth On and Around California Tribal Reservations with a Reward and Reminder Retail Intervention</dc:title>
<dc:identifier>pmid:38747187</dc:identifier>
<dc:identifier>doi:10.1093/ntr/ntae110</dc:identifier>
</item>
<item>
<title>The impact of pneumococcal serotype replacement on the effectiveness of a national immunization program: a population-based active surveillance cohort study in New Zealand</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38745973/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>BACKGROUND: In Aotearoa New Zealand (NZ) PCV7 was introduced in 2008, then PCV10 in 2011 and PCV13 in 2014. In 2017 PCV10 was re-introduced, replacing PCV13. In the present study, we investigate the resultant rapidly changing invasive pneumococcal disease (IPD) epidemiology.</description>
<content:encoded><![CDATA[<div>Lancet Reg Health West Pac. 2024 May 8;46:101082. doi: 10.1016/j.lanwpc.2024.101082. eCollection 2024 May.ABSTRACTBACKGROUND: In Aotearoa New Zealand (NZ) PCV7 was introduced in 2008, then PCV10 in 2011 and PCV13 in 2014. In 2017 PCV10 was re-introduced, replacing PCV13. In the present study, we investigate the resultant rapidly changing invasive pneumococcal disease (IPD) epidemiology.METHODS: We compare the IPD incidence rate ratio (IRR) in NZ (2022 versus 2020) with other countries, and describe the IPD epidemiology (including trends in overall IPD and serotype 19A, and antimicrobial resistance) within NZ. Additionally, we performed a genomic-epidemiology investigation identifying the most common 19A sequence types and associated risk factors.FINDINGS: Though IPD incidence rates have increased in the US and Australia (2021-22) after declines in 2020, in NZ the incidence rate is the highest since 2011 with a significantly higher IRR than US (p < 0.01). Incidence rates among children <2 and adults 65 or over in 2022 are the highest since 2009, driven by significant increases of serotype 19A (p = 0.01). Māori and Pacific peoples are experiencing the highest rates since 2009. Further, penicillin resistance among 19A isolates has increased from 39% (2012) to 84% (2021) (p = 0.02). Genomic sequencing identified the more virulent ST-2062 as most common among 19A isolates sequenced, increasing from 5% (2010) to 55% (2022).INTERPRETATION: With very high incidence rates of IPD in NZ, inadequate protection against 19A, increasing resistance, and a more virulent 19A clade, targeted public health campaigns and increased PCV13 availability are needed.FUNDING: The NZ Ministry of Health funds IPD surveillance and typing in NZ.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38745973/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38745973</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11091704/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11091704</a> | DOI:<a href=https://doi.org/10.1016/j.lanwpc.2024.101082>10.1016/j.lanwpc.2024.101082</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38745973</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Andrew Anglemyer</dc:creator>
<dc:creator>Xiaoyun Ren</dc:creator>
<dc:creator>Charlotte Gilkison</dc:creator>
<dc:creator>Zoe Kumbaroff</dc:creator>
<dc:creator>Julie Morgan</dc:creator>
<dc:creator>Kara DuBray</dc:creator>
<dc:creator>Audrey Tiong</dc:creator>
<dc:creator>Arthur Reingold</dc:creator>
<dc:creator>Tony Walls</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>The Lancet regional health. Western Pacific</dc:source>
<dc:title>The impact of pneumococcal serotype replacement on the effectiveness of a national immunization program: a population-based active surveillance cohort study in New Zealand</dc:title>
<dc:identifier>pmid:38745973</dc:identifier>
<dc:identifier>pmc:PMC11091704</dc:identifier>
<dc:identifier>doi:10.1016/j.lanwpc.2024.101082</dc:identifier>
</item>
<item>
<title>Trends of Acute Myocardial Infarction Mortality in People Over 65 Years Old in the United States From 1999-2020: Insight From the CDC-WONDER Database</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38745786/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Background Over the past two decades, there have been numerous advances in acute myocardial infarction (AMI) care. We assessed the impact of these advances on the trend of AMI-related mortality. Methods This retrospective analysis of the Centers for Disease Control's Wide-ranging Online Data for Epidemiologic Research (CDC_WONDER) database focused on AMI-related mortality in individuals aged 65 and older in the United States from 1999 to 2020. Trends -n crude and age-adjusted mortality rates...</description>
<content:encoded><![CDATA[<div>Cureus. 2024 Apr 14;16(4):e58225. doi: 10.7759/cureus.58225. eCollection 2024 Apr.ABSTRACTBackground Over the past two decades, there have been numerous advances in acute myocardial infarction (AMI) care. We assessed the impact of these advances on the trend of AMI-related mortality. Methods This retrospective analysis of the Centers for Disease Control's Wide-ranging Online Data for Epidemiologic Research (CDC_WONDER) database focused on AMI-related mortality in individuals aged 65 and older in the United States from 1999 to 2020. Trends -n crude and age-adjusted mortality rates (AAMR) were assessed based on socio-demographic and regional variables using Joinpoint Regression software (Joinpoint Regression Program, Version 5.0.2 - May 2023; Statistical Methodology and Applications Branch, Surveillance Research Program, National Cancer Institute Bethesda, Maryland). Annual percentage change (APC) with 95% confidence intervals (CIs) for the AAMRs were calculated for the line segments linking a Joinpoint using a data-driven weighted Bayesian Information Criterion (BIC) model. Results There were 2,354,971 AMI-related deaths with an overall decline in the AAMR from 474.6 in 1999 to 153.2 in 2020 and an average annual percentage change (AAPC) of -5.3 (95% CI -5.4 to -5.2). Notable declines were observed across gender, race, age groups, and urbanization levels. However, the rate of AMI-related deaths at decedents' homes slowed down between 2008 and 2020 and climbed up between 2018 and 2020. In addition to this, nonmetropolitan areas were found to have a significantly lower decline in mortality when compared to large and medium/small metropolitan areas. Conclusion While there is an overall positive trend in reducing AMI-associated mortality, disparities persist, emphasizing the need for targeted interventions.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38745786/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38745786</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11091843/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">PMC11091843</a> | DOI:<a href=https://doi.org/10.7759/cureus.58225>10.7759/cureus.58225</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38745786</guid>
<pubDate>Wed, 15 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Bekure B Siraw</dc:creator>
<dc:creator>Didien Meyahnwi</dc:creator>
<dc:creator>Yordanos T Tafesse</dc:creator>
<dc:creator>Biruk B Siraw</dc:creator>
<dc:creator>Juveriya Yasmeen</dc:creator>
<dc:creator>Samrawit Melka</dc:creator>
<dc:date>2024-05-15</dc:date>
<dc:source>Cureus</dc:source>
<dc:title>Trends of Acute Myocardial Infarction Mortality in People Over 65 Years Old in the United States From 1999-2020: Insight From the CDC-WONDER Database</dc:title>
<dc:identifier>pmid:38745786</dc:identifier>
<dc:identifier>pmc:PMC11091843</dc:identifier>
<dc:identifier>doi:10.7759/cureus.58225</dc:identifier>
</item>
<item>
<title>The speech neuroprosthesis</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38745103/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>Loss of speech after paralysis is devastating, but circumventing motor-pathway injury by directly decoding speech from intact cortical activity has the potential to restore natural communication and self-expression. Recent discoveries have defined how key features of speech production are facilitated by the coordinated activity of vocal-tract articulatory and motor-planning cortical representations. In this Review, we highlight such progress and how it has led to successful speech decoding,...</description>
<content:encoded><![CDATA[<div>Nat Rev Neurosci. 2024 May 14. doi: 10.1038/s41583-024-00819-9. Online ahead of print.ABSTRACTLoss of speech after paralysis is devastating, but circumventing motor-pathway injury by directly decoding speech from intact cortical activity has the potential to restore natural communication and self-expression. Recent discoveries have defined how key features of speech production are facilitated by the coordinated activity of vocal-tract articulatory and motor-planning cortical representations. In this Review, we highlight such progress and how it has led to successful speech decoding, first in individuals implanted with intracranial electrodes for clinical epilepsy monitoring and subsequently in individuals with paralysis as part of early feasibility clinical trials to restore speech. We discuss high-spatiotemporal-resolution neural interfaces and the adaptation of state-of-the-art speech computational algorithms that have driven rapid and substantial progress in decoding neural activity into text, audible speech, and facial movements. Although restoring natural speech is a long-term goal, speech neuroprostheses already have performance levels that surpass communication rates offered by current assistive-communication technology. Given this accelerated rate of progress in the field, we propose key evaluation metrics for speed and accuracy, among others, to help standardize across studies. We finish by highlighting several directions to more fully explore the multidimensional feature space of speech and language, which will continue to accelerate progress towards a clinically viable speech neuroprosthesis.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38745103/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38745103</a> | DOI:<a href=https://doi.org/10.1038/s41583-024-00819-9>10.1038/s41583-024-00819-9</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38745103</guid>
<pubDate>Tue, 14 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Alexander B Silva</dc:creator>
<dc:creator>Kaylo T Littlejohn</dc:creator>
<dc:creator>Jessie R Liu</dc:creator>
<dc:creator>David A Moses</dc:creator>
<dc:creator>Edward F Chang</dc:creator>
<dc:date>2024-05-14</dc:date>
<dc:source>Nature reviews. Neuroscience</dc:source>
<dc:title>The speech neuroprosthesis</dc:title>
<dc:identifier>pmid:38745103</dc:identifier>
<dc:identifier>doi:10.1038/s41583-024-00819-9</dc:identifier>
</item>
<item>
<title>Roadmap on nanoscale magnetic resonance imaging</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38744268/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&fc=None&ff=20240519083409&v=2.18.0.post9+e462414</link>
<description>The field of nanoscale magnetic resonance imaging (NanoMRI) was started 30 years ago. It was motivated by the desire to image single molecules and molecular assemblies, such as proteins and virus particles, with near-atomic spatial resolution and on a length scale of 100 nm. Over the years, the NanoMRI field has also expanded to include the goal of useful high-resolution nuclear magnetic resonance (NMR) spectroscopy of molecules under ambient conditions, including samples up to the micron-scale....</description>
<content:encoded><![CDATA[<div>Nanotechnology. 2024 May 14. doi: 10.1088/1361-6528/ad4b23. Online ahead of print.ABSTRACTThe field of nanoscale magnetic resonance imaging (NanoMRI) was started 30 years ago. It was motivated by the desire to image single molecules and molecular assemblies, such as proteins and virus particles, with near-atomic spatial resolution and on a length scale of 100 nm. Over the years, the NanoMRI field has also expanded to include the goal of useful high-resolution nuclear magnetic resonance (NMR) spectroscopy of molecules under ambient conditions, including samples up to the micron-scale. The realization of these goals requires the development of spin detection techniques that are many orders of magnitude more sensitive than conventional NMR and MRI, capable of detecting and controlling nanoscale ensembles of spins. Over the years, a number of different technical approaches to NanoMRI have emerged, each possessing a distinct set of capabilities for basic and applied areas of science. The goal of this roadmap article is to report the current state of the art in NanoMRI technologies, outline the areas where they are poised to have impact, identify the challenges that lie ahead, and propose methods to meet these challenges. This roadmap also shows how developments in NanoMRI techniques can lead to breakthroughs in emerging quantum science and technology applications.&#xD.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38744268/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1toH0ZWNzwdzzQZ8GDwDjd9sHxXJ9pr6UOGUP4egEIOYmwNMxJ&ff=20240519083409&v=2.18.0.post9+e462414">38744268</a> | DOI:<a href=https://doi.org/10.1088/1361-6528/ad4b23>10.1088/1361-6528/ad4b23</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38744268</guid>
<pubDate>Tue, 14 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Raffi Budakian</dc:creator>
<dc:creator>Amit Finkler</dc:creator>
<dc:creator>Alexander Eichler</dc:creator>
<dc:creator>Martino Poggio</dc:creator>
<dc:creator>Christian L Degen</dc:creator>
<dc:creator>Sahand Tabatabaei</dc:creator>
<dc:creator>Inhee Lee</dc:creator>
<dc:creator>P Chris Hammel</dc:creator>
<dc:creator>Eugene Polzik</dc:creator>
<dc:creator>Tim H Taminiau</dc:creator>
<dc:creator>Ronald L Walsworth</dc:creator>
<dc:creator>Paz London</dc:creator>
<dc:creator>Ania Bleszynski Jayich</dc:creator>
<dc:creator>Ashok Ajoy</dc:creator>
<dc:creator>Arjun Pillai</dc:creator>
<dc:creator>Jörg Wrachtrup</dc:creator>
<dc:creator>Fedor Jelezko</dc:creator>
<dc:creator>Yujeong Bae</dc:creator>
<dc:creator>Andreas J Heinrich</dc:creator>
<dc:creator>Christian R Ast</dc:creator>
<dc:creator>Patrice Bertet</dc:creator>
<dc:creator>Paola Cappellaro</dc:creator>
<dc:creator>Cristian Bonato</dc:creator>
<dc:creator>Yoann Altmann</dc:creator>
<dc:creator>Erik Manuel Gauger</dc:creator>
<dc:date>2024-05-14</dc:date>
<dc:source>Nanotechnology</dc:source>
<dc:title>Roadmap on nanoscale magnetic resonance imaging</dc:title>
<dc:identifier>pmid:38744268</dc:identifier>
<dc:identifier>doi:10.1088/1361-6528/ad4b23</dc:identifier>
</item>
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