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Source: http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk

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<title>neuromuscular disorders</title>
<link>https://pubmed.ncbi.nlm.nih.gov/rss-feed/?feed_id=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414&utm_medium=rss&utm_source=Feedvalidator&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk</link>
<description>neuromuscular disorders: Latest results from PubMed</description>
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<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
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<title>Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38710832/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein], and skin changes) is a rare systemic disorder characterized by various symptoms caused by underlying plasma cell (PC) dyscrasia. Detection of monoclonal PCs is mandatory for the diagnosis of POEMS syndrome; however, the usefulness of EuroFlow-based next-generation flow cytometry (EuroFlow-NGF) in POEMS syndrome for detecting monoclonal PCs in bone marrow (BM) and the gating strategy suitable for flow...</description>
<content:encoded><![CDATA[<div>Sci Rep. 2024 May 6;14(1):10362. doi: 10.1038/s41598-024-61034-1.ABSTRACTPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein], and skin changes) is a rare systemic disorder characterized by various symptoms caused by underlying plasma cell (PC) dyscrasia. Detection of monoclonal PCs is mandatory for the diagnosis of POEMS syndrome; however, the usefulness of EuroFlow-based next-generation flow cytometry (EuroFlow-NGF) in POEMS syndrome for detecting monoclonal PCs in bone marrow (BM) and the gating strategy suitable for flow cytometry study of POEMS syndrome remain unknown. We employed EuroFlow-NGF-based single-tube eight-color multiparameter flow cytometry (MM-flow) and established a new gating strategy (POEMS-flow) to detect the monoclonal PCs in POEMS syndrome, gating CD38 broadly from dim to bright and CD45 narrowly from negative to dim compared to MM-flow. MM-flow detected monoclonal PCs in 9/25 (36.0%) cases, including 2/2 immunofixation electrophoresis (IFE)-negative cases (100%). However, POEMS-flow detected monoclonal PCs in 18/25 cases (72.0%), including 2/2 IFE-negative cases (100%). POEMS-flow detected monoclonal PCs with immunophenotypes of CD19- in 17/18 (94.4%). In six cases where post-treatment samples were available, the size of the clones was significantly reduced after the treatment (P = 0.031). POEMS-flow can enhance the identification rate of monoclonal PCs in POEMS syndrome and become a valuable tool for the diagnosis of POEMS syndrome.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38710832/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38710832</a> | DOI:<a href=https://doi.org/10.1038/s41598-024-61034-1>10.1038/s41598-024-61034-1</a></div>]]></content:encoded>
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<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Arata Ishii</dc:creator>
<dc:creator>Shokichi Tsukamoto</dc:creator>
<dc:creator>Naoya Mimura</dc:creator>
<dc:creator>Yurie Miyamoto-Nagai</dc:creator>
<dc:creator>Yusuke Isshiki</dc:creator>
<dc:creator>Shinichiro Matsui</dc:creator>
<dc:creator>Sanshiro Nakao</dc:creator>
<dc:creator>Asuka Shibamiya</dc:creator>
<dc:creator>Yutaro Hino</dc:creator>
<dc:creator>Kensuke Kayamori</dc:creator>
<dc:creator>Nagisa Oshima-Hasegawa</dc:creator>
<dc:creator>Tomoya Muto</dc:creator>
<dc:creator>Yusuke Takeda</dc:creator>
<dc:creator>Tomoki Suichi</dc:creator>
<dc:creator>Sonoko Misawa</dc:creator>
<dc:creator>Chikako Ohwada</dc:creator>
<dc:creator>Koutaro Yokote</dc:creator>
<dc:creator>Satoshi Kuwabara</dc:creator>
<dc:creator>Chiaki Nakaseko</dc:creator>
<dc:creator>Hiroyuki Takamatsu</dc:creator>
<dc:creator>Emiko Sakaida</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Scientific reports</dc:source>
<dc:title>Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry</dc:title>
<dc:identifier>pmid:38710832</dc:identifier>
<dc:identifier>doi:10.1038/s41598-024-61034-1</dc:identifier>
</item>
<item>
<title>Neurological features of Hansen disease: a retrospective, multicenter cohort study</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38710787/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>To elucidate the neurological features of Hansen disease. The medical records of patients with confirmed Hansen disease transferred from the neurology department were reviewed, and all medical and neurological manifestations of Hansen disease were assessed. Eleven patients with confirmed Hansen disease, 10 with newly detected Hansen disease and 1 with relapsed Hansen disease, who visited neurology departments were enrolled. The newly detected patients with Hansen disease were classified as...</description>
<content:encoded><![CDATA[<div>Sci Rep. 2024 May 6;14(1):10374. doi: 10.1038/s41598-024-60457-0.ABSTRACTTo elucidate the neurological features of Hansen disease. The medical records of patients with confirmed Hansen disease transferred from the neurology department were reviewed, and all medical and neurological manifestations of Hansen disease were assessed. Eleven patients with confirmed Hansen disease, 10 with newly detected Hansen disease and 1 with relapsed Hansen disease, who visited neurology departments were enrolled. The newly detected patients with Hansen disease were classified as having lepromatous leprosy (LL, n = 1), borderline lepromatous leprosy (BL, n = 2), borderline leprosy (BB, n = 2), borderline tuberculoid leprosy (BT, n = 1), tuberculoid leprosy (TT, n = 2), or pure neural leprosy (PNL, n = 2). All of the patients with confirmed Hansen were diagnosed with peripheral neuropathy (100.00%, 11/11). The symptoms and signs presented were mainly limb numbness (100.00%, 11/11), sensory and motor dysfunction (100.00%, 11/11), decreased muscle strength (90.90%, 10/11), and skin lesions (81.81%, 9/11). Nerve morphological features in nerve ultrasonography (US) included peripheral nerve asymmetry and segmental thickening (100.00%, 9/9). For neuro-electrophysiology feature, the frequency of no response of sensory nerves was significantly higher than those of motor nerves [(51.21% 42/82) vs (24.70%, 21/85)(P = 0.0183*)] by electrodiagnostic (EDX) studies. Nerve histological features in nerve biopsy analysis included demyelination (100.00%, 5/5) and axonal damage (60.00%, 3/5). In addition to confirmed diagnoses by acid-fast bacteria (AFB) staining (54.54%, 6/11) and skin pathology analysis (100.00%, 8/8), serology and molecular technology were positive in 36.36% (4/11) and 100.00% (11/11) of confirmed patients of Hansen disease, respectively. It is not uncommon for patients of Hansen disease to visit neurology departments due to peripheral neuropathy. The main pathological features of affected nerves are demyelination and axonal damage. The combination of nerve US, EDX studies, nerve biopsy, and serological and molecular tests can improve the diagnosis of Hansen disease.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38710787/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38710787</a> | DOI:<a href=https://doi.org/10.1038/s41598-024-60457-0>10.1038/s41598-024-60457-0</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38710787</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Xiaohua Chen</dc:creator>
<dc:creator>Li Di</dc:creator>
<dc:creator>Min Qian</dc:creator>
<dc:creator>Dongchao Shen</dc:creator>
<dc:creator>Xinhong Feng</dc:creator>
<dc:creator>Xiqing Zhang</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Scientific reports</dc:source>
<dc:title>Neurological features of Hansen disease: a retrospective, multicenter cohort study</dc:title>
<dc:identifier>pmid:38710787</dc:identifier>
<dc:identifier>doi:10.1038/s41598-024-60457-0</dc:identifier>
</item>
<item>
<title>Neuropathic pain in cats: Mechanisms and multimodal management</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38710218/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Chronic pain is a significant welfare concern in cats, and neuropathic pain, which arises from aberrant processing of sensory signals within the nervous system, is a subcategory of this type of pain. To comprehend this condition and how multimodal pharmacotherapy plays a central role in alleviating discomfort, it is crucial to delve into the anatomy of nociception and pain perception. In addition, there is an intricate interplay between emotional health and chronic pain in cats, and...</description>
<content:encoded><![CDATA[<div>J Feline Med Surg. 2024 May;26(5):1098612X241246518. doi: 10.1177/1098612X241246518.ABSTRACTChronic pain is a significant welfare concern in cats, and neuropathic pain, which arises from aberrant processing of sensory signals within the nervous system, is a subcategory of this type of pain. To comprehend this condition and how multimodal pharmacotherapy plays a central role in alleviating discomfort, it is crucial to delve into the anatomy of nociception and pain perception. In addition, there is an intricate interplay between emotional health and chronic pain in cats, and understanding and addressing the emotional factors that contribute to pain perception, and vice versa, is essential for comprehensive care.Clinical approach:Neuropathic pain is suspected if there is abnormal sensation in the area of the distribution of pain, together with a positive response to trial treatment with drugs effective for neuropathic pain. Ideally, this clinical suspicion would be supported by confirmation of a lesion at this neurolocalisation using diagnostic modalities such as MRI and neuroelectrophysiology. Alternatively, there may be a history of known trauma at that site. A variety of therapies, including analgesic, anti-inflammatory and adjuvant drugs, and neuromodulation (eg, TENS or acupuncture), can be employed to address different facets of pain pathways.Aim:This review article, aimed at primary care/ general practitioners, focuses on the identification and management of neuropathic pain in cats. Three case vignettes are included and a structured treatment algorithm is presented to guide veterinarians in tailoring interventions.Evidence base:The review draws on current literature, where available, along with the author's extensive experience and research.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38710218/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38710218</a> | DOI:<a href=https://doi.org/10.1177/1098612X241246518>10.1177/1098612X241246518</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38710218</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Clare Rusbridge</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Journal of feline medicine and surgery</dc:source>
<dc:title>Neuropathic pain in cats: Mechanisms and multimodal management</dc:title>
<dc:identifier>pmid:38710218</dc:identifier>
<dc:identifier>doi:10.1177/1098612X241246518</dc:identifier>
</item>
<item>
<title>Electrical Stimulation-Based Twitch Exercise Suppresses Progression of Immobilization-Induced Muscle Fibrosis via Downregulation of PGC-1?/VEGF Pathway</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38710059/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>This study aimed to determine whether electrical stimulation-based twitch exercise is effective in inhibiting the progression of immobilization-induced muscle fibrosis. 19 Wistar rats were randomly divided into a control group (n=6), an immobilization group (n=6; with immobilization only), and a Belt group (n=7; with immobilization and twitch exercise through the belt electrode device, beginning 2 weeks after immobilization). The bilateral soleus muscles were harvested after the experimental...</description>
<content:encoded><![CDATA[<div>Physiol Res. 2024 Apr 30;73(2):285-294.ABSTRACTThis study aimed to determine whether electrical stimulation-based twitch exercise is effective in inhibiting the progression of immobilization-induced muscle fibrosis. 19 Wistar rats were randomly divided into a control group (n=6), an immobilization group (n=6; with immobilization only), and a Belt group (n=7; with immobilization and twitch exercise through the belt electrode device, beginning 2 weeks after immobilization). The bilateral soleus muscles were harvested after the experimental period. The right soleus muscles were used for histological analysis, and the left soleus muscles were used for biochemical and molecular biological analysis. As a result, in the picrosirius red images, the perimysium and endomysium were thicker in both the immobilization and Belt groups compared to the control group. However, the perimysium and endomysium thickening were suppressed in the Belt group. The hydroxyproline content and alpha-SMA, TGF-beta1, and HIF-1alpha mRNA expressions were significantly higher in the immobilization and belt groups than in the control group. These expressions were significantly lower in the Belt group than in the immobilization group. The capillary-to-myofiber ratio and the mRNA expressions of VEGF and PGC-1alpha were significantly lower in the immobilization and belt groups than in the control group, these were significantly higher in the Belt group than in the immobilization group. From these results, Electrical stimulation-based twitch exercise using the belt electrode device may prevent the progression of immobilization-induced muscle fibrosis caused by downregulating PGC-1alpha/VEGF pathway, we surmised that this intervention strategy might be effective against the progression of muscle contracture. Keywords: Immobilization, Skeletal muscle, Fibrosis, Electrical stimulation-based twitch exercise, PGC-1alpha/VEGF pathway.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38710059/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38710059</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38710059</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Y Honda</dc:creator>
<dc:creator>A Takahashi</dc:creator>
<dc:creator>N Tanaka</dc:creator>
<dc:creator>Y Kajiwara</dc:creator>
<dc:creator>R Sasaki</dc:creator>
<dc:creator>H Kataoka</dc:creator>
<dc:creator>J Sakamoto</dc:creator>
<dc:creator>M Okita</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Physiological research</dc:source>
<dc:title>Electrical Stimulation-Based Twitch Exercise Suppresses Progression of Immobilization-Induced Muscle Fibrosis via Downregulation of PGC-1?/VEGF Pathway</dc:title>
<dc:identifier>pmid:38710059</dc:identifier>
</item>
<item>
<title>Factors Associated With Early Motor Function Trajectories in DMD After Glucocorticoid Initiation: Post Hoc Analysis of the FOR-DMD Trial</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38710006/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>BACKGROUND AND OBJECTIVES: Clinical trials in Duchenne muscular dystrophy (DMD) require 3-6 months of stable glucocorticoids, and the primary outcome is explored at 48-52 weeks. The factors that influence the clinical outcome assessment (COA) trajectories soon after glucocorticoid initiation are relevant for the design and analysis of clinical trials of novel drugs. We describe early COA trajectories, associated factors, and the time from glucocorticoid initiation to COA peak.</description>
<content:encoded><![CDATA[<div>Neurology. 2024 May 28;102(10):e209206. doi: 10.1212/WNL.0000000000209206. Epub 2024 May 6.ABSTRACTBACKGROUND AND OBJECTIVES: Clinical trials in Duchenne muscular dystrophy (DMD) require 3-6 months of stable glucocorticoids, and the primary outcome is explored at 48-52 weeks. The factors that influence the clinical outcome assessment (COA) trajectories soon after glucocorticoid initiation are relevant for the design and analysis of clinical trials of novel drugs. We describe early COA trajectories, associated factors, and the time from glucocorticoid initiation to COA peak.METHODS: This was a prospective 18-month analysis of the Finding the Optimum Corticosteroid Regimen for Duchenne Muscular Dystrophy study. Four COAs were investigated: rise from supine velocity (RFV), 10-meter walk/run velocity (10MWRV), North Star Ambulatory Assessment (NSAA) total score, and 6-minute walk test distance (6MWT). The relationships of baseline age (4-5 vs 6-7 years), COA baseline performance, genotype, and glucocorticoid regimen (daily vs intermittent) with the COA trajectories were evaluated using linear mixed-effects models.RESULTS: One hundred ninety-six glucocorticoid-naïve boys with DMD aged 4-7 years were enrolled. The mean age at baseline was 5.9 ± 1.0 years, 66% (n = 130) were on daily regimens, 55% (n = 107) showed a 6MWT distance >330 metres; 41% (n = 78) showed RFV >0.2 rise/s; 76% (n = 149) showed 10MWRV >0.142 10m/s, and 41.0% (n = 79) showed NSAA total score >22 points. Mean COA trajectories differed by age at glucocorticoid initiation (p < 0.01 for RFV, 10MWRV, and NSAA; p < 0.05 for 6MWT) and regimen (p < 0.01 for RFV, 10MWRV, and NSAA). Boys younger than 6 years reached their peak performance 12-18 months after glucocorticoid initiation. Boys aged 6 years or older on a daily regimen peaked between months 9 and 12 and those on an intermittent regimen by 9 months. The baseline COA performance was associated with the NSAA (p < 0.01) and the 6MWT trajectory in boys younger than 6 years on a daily regimen (p < 0.01). Differences in the mean trajectories by genotype were not significant.DISCUSSION: Glucocorticoid regimen, age, duration of glucocorticoid exposure, and baseline COA performance need to be considered in the design and analysis of clinical trials in young boys with DMD.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38710006/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38710006</a> | DOI:<a href=https://doi.org/10.1212/WNL.0000000000209206>10.1212/WNL.0000000000209206</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38710006</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Marianela Schiava</dc:creator>
<dc:creator>Michael P McDermott</dc:creator>
<dc:creator>Jonathan Broomfield</dc:creator>
<dc:creator>Keith R Abrams</dc:creator>
<dc:creator>Anna G Mayhew</dc:creator>
<dc:creator>Craig M McDonald</dc:creator>
<dc:creator>William B Martens</dc:creator>
<dc:creator>Stephanie J Gregory</dc:creator>
<dc:creator>Robert C Griggs</dc:creator>
<dc:creator>Michela Guglieri</dc:creator>
<dc:creator>FOR-DMD investigators of the Muscle Study Group</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Neurology</dc:source>
<dc:title>Factors Associated With Early Motor Function Trajectories in DMD After Glucocorticoid Initiation: Post Hoc Analysis of the FOR-DMD Trial</dc:title>
<dc:identifier>pmid:38710006</dc:identifier>
<dc:identifier>doi:10.1212/WNL.0000000000209206</dc:identifier>
</item>
<item>
<title>Contemporary Approach to Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38710002/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Most malignant peripheral nerve sheath tumors (MPNSTs) are clinically aggressive high-grade sarcomas, arising in individuals with neurofibromatosis type 1 (NF1) at a significantly elevated estimated lifetime frequency of 8%-13%. In the setting of NF1, MPNSTs arise from malignant transformation of benign plexiform neurofibroma and borderline atypical neurofibromas. Composed of neoplastic cells from the Schwannian lineage, these cancers recur in approximately 50% of individuals, and most patients...</description>
<content:encoded><![CDATA[<div>Am Soc Clin Oncol Educ Book. 2024 Jun;44(3):e432242. doi: 10.1200/EDBK_432242.ABSTRACTMost malignant peripheral nerve sheath tumors (MPNSTs) are clinically aggressive high-grade sarcomas, arising in individuals with neurofibromatosis type 1 (NF1) at a significantly elevated estimated lifetime frequency of 8%-13%. In the setting of NF1, MPNSTs arise from malignant transformation of benign plexiform neurofibroma and borderline atypical neurofibromas. Composed of neoplastic cells from the Schwannian lineage, these cancers recur in approximately 50% of individuals, and most patients die within five years of diagnosis, despite surgical resection, radiation, and chemotherapy. Treatment for metastatic disease is limited to cytotoxic chemotherapy and investigational clinical trials. In this article, we review the pathophysiology of this aggressive cancer and current approaches to surveillance and treatment.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38710002/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38710002</a> | DOI:<a href=https://doi.org/10.1200/EDBK_432242>10.1200/EDBK_432242</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38710002</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Angela C Hirbe</dc:creator>
<dc:creator>Carina A Dehner</dc:creator>
<dc:creator>Eva Dombi</dc:creator>
<dc:creator>Vanessa Eulo</dc:creator>
<dc:creator>Andrea M Gross</dc:creator>
<dc:creator>Taylor Sundby</dc:creator>
<dc:creator>Alexander J Lazar</dc:creator>
<dc:creator>Brigitte C Widemann</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting</dc:source>
<dc:title>Contemporary Approach to Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors</dc:title>
<dc:identifier>pmid:38710002</dc:identifier>
<dc:identifier>doi:10.1200/EDBK_432242</dc:identifier>
</item>
<item>
<title>Heterogeneity of cognitive impairments in myotonic dystrophy type 1 explained by three distinct cognitive profiles</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38709306/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: We found different cognitive profiles in our DM1 population, which seem influenced by age and DM1 duration. Our findings may explain the heterogeneity of studies about cognition in DM1, and suggest a potential neurodegenerative mechanism in DM1 adults.</description>
<content:encoded><![CDATA[<div>J Neurol. 2024 May 6. doi: 10.1007/s00415-024-12404-2. Online ahead of print.ABSTRACTBACKGROUND: Severity and nature of cognitive impairments in Myotonic dystrophy type 1 (DM1) are heterogeneous among studies. We hypothesized that this heterogeneity is explained by different cognitive profiles in DM1, with different clinical, biological and behavioral features.METHODS: Adult patients with genetically proven DM1 underwent a clinical, neuropsychological and behavioral assessment. We conducted a k-means clustering analysis on 9 cognitive tests representative of different domains (verbal/non-verbal episodic memory, visuo-constructive abilities, visual gnosis, executive functions, information processing speed).RESULTS: We included 124 DM1 patients. Mean age was 45.1 ± 13.5 years [19.8-73.2], mean age of onset was 30.4 ± 15.7 years [5-72], and mean CTG triplets' expansion size was 489.7 ± 351.8 [50-1600]. We found 3 cognitive clusters, including, respectively, 84, 29 and 11 patients. The first cluster included patients with more preserved cognitive functions; the second included patients with worse cognitive performances which predominate on executive functions; and the third even more pronounced and diffuse cognitive deficits. Younger patients, with a more recent DM1 clinical onset, higher educational level were more frequently classified in the cluster with more preserved cognitive functions. There were no significant differences between clusters regarding CTG triplets' expansion, neither age at DM1 onset, nor most of behavioral measures.CONCLUSIONS: We found different cognitive profiles in our DM1 population, which seem influenced by age and DM1 duration. Our findings may explain the heterogeneity of studies about cognition in DM1, and suggest a potential neurodegenerative mechanism in DM1 adults.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38709306/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38709306</a> | DOI:<a href=https://doi.org/10.1007/s00415-024-12404-2>10.1007/s00415-024-12404-2</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38709306</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jean-Baptiste Davion</dc:creator>
<dc:creator>Céline Tard</dc:creator>
<dc:creator>Loren Fragoso</dc:creator>
<dc:creator>Amina Wilu-Wilu</dc:creator>
<dc:creator>Emilie Skrobala</dc:creator>
<dc:creator>Luc Defebvre</dc:creator>
<dc:creator>Xavier Delbeuck</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Journal of neurology</dc:source>
<dc:title>Heterogeneity of cognitive impairments in myotonic dystrophy type 1 explained by three distinct cognitive profiles</dc:title>
<dc:identifier>pmid:38709306</dc:identifier>
<dc:identifier>doi:10.1007/s00415-024-12404-2</dc:identifier>
</item>
<item>
<title>Assessing Rat Diaphragm Motor Unit Connectivity Outcome Measures as Quantitative Biomarkers of Phrenic Motor Neuron Degeneration and Compensation</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38709037/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Loss of ventilatory muscle function is a consequence of motor neuron injury and neurodegeneration (e.g., cervical spinal cord injury and amyotrophic lateral sclerosis, respectively). Phrenic motor neurons are the final link between the central nervous system and muscle, and their respective motor units (groups of muscle fibers innervated by a single motor neuron) represent the smallest functional unit of the neuromuscular ventilatory system. Compound muscle action potential (CMAP), single motor...</description>
<content:encoded><![CDATA[<div>J Vis Exp. 2024 Apr 19;(206). doi: 10.3791/66568.ABSTRACTLoss of ventilatory muscle function is a consequence of motor neuron injury and neurodegeneration (e.g., cervical spinal cord injury and amyotrophic lateral sclerosis, respectively). Phrenic motor neurons are the final link between the central nervous system and muscle, and their respective motor units (groups of muscle fibers innervated by a single motor neuron) represent the smallest functional unit of the neuromuscular ventilatory system. Compound muscle action potential (CMAP), single motor unit potential (SMUP), and motor unit number estimation (MUNE) are established electrophysiological approaches that enable the longitudinal assessment of motor unit integrity in animal models over time but have mostly been applied to limb muscles. Therefore, the objectives of this study are to describe an approach in preclinical rodent studies that can be used longitudinally to quantify the phrenic MUNE, motor unit size (represented as SMUP), and CMAP, and then to demonstrate the utility of these approaches in a motor neuron loss model. Sensitive, objective, and translationally relevant biomarkers for neuronal injury, degeneration, and regeneration in motor neuron injury and diseases can significantly aid and accelerate experimental research discoveries to clinical testing.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38709037/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38709037</a> | DOI:<a href=https://doi.org/10.3791/66568>10.3791/66568</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38709037</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Arsh Ketabforoush</dc:creator>
<dc:creator>Meifang Wang</dc:creator>
<dc:creator>Catherine L Smith</dc:creator>
<dc:creator>William David Arnold</dc:creator>
<dc:creator>Nicole L Nichols</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Journal of visualized experiments : JoVE</dc:source>
<dc:title>Assessing Rat Diaphragm Motor Unit Connectivity Outcome Measures as Quantitative Biomarkers of Phrenic Motor Neuron Degeneration and Compensation</dc:title>
<dc:identifier>pmid:38709037</dc:identifier>
<dc:identifier>doi:10.3791/66568</dc:identifier>
</item>
<item>
<title>Insights on Natural Products Against Amyotrophic Lateral Sclerosis (ALS)</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38708921/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes the death of motor neurons and consequent muscle paralysis. Despite many efforts to address it, current therapy targeting ALS remains limited, increasing the interest in complementary therapies. Over the years, several herbal preparations and medicinal plants have been studied to prevent and treat this disease, which has received remarkable attention due to their blood-brain barrier penetration properties...</description>
<content:encoded><![CDATA[<div>Curr Neuropharmacol. 2024;22(7):1169-1188. doi: 10.2174/1570159X22666231016153606.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes the death of motor neurons and consequent muscle paralysis. Despite many efforts to address it, current therapy targeting ALS remains limited, increasing the interest in complementary therapies. Over the years, several herbal preparations and medicinal plants have been studied to prevent and treat this disease, which has received remarkable attention due to their blood-brain barrier penetration properties and low toxicity. Thus, this review presents the therapeutic potential of a variety of medicinal herbs and their relationship with ALS and their physiopathological pathways.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38708921/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38708921</a> | DOI:<a href=https://doi.org/10.2174/1570159X22666231016153606>10.2174/1570159X22666231016153606</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38708921</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Kadja Luana Chagas Monteiro</dc:creator>
<dc:creator>Marcone Gomes Dos Santos Alcântara</dc:creator>
<dc:creator>Thiago Mendonça de Aquino</dc:creator>
<dc:creator>Edeildo Ferreira da Silva-Júnior</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Current neuropharmacology</dc:source>
<dc:title>Insights on Natural Products Against Amyotrophic Lateral Sclerosis (ALS)</dc:title>
<dc:identifier>pmid:38708921</dc:identifier>
<dc:identifier>doi:10.2174/1570159X22666231016153606</dc:identifier>
</item>
<item>
<title>Malunion of a clavicle fracture caused thoracic outlet syndrome in a professional violinist</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38708702/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Clavicle fractures are a common injury in adults. Most patients are treated non-operatively. In this case report, a 53-year-old professional violinist had a midt shaft clavicula fracture and was treated non-operatively. The fracture healed, but the patient developed thoracic outlet syndrome (TOS) and a venous thrombosis when playing violin. Surgery with restoration of the normal anatomy alleviated the symptoms and six months later she was symptom free and playing violin again. TOS is a rare...</description>
<content:encoded><![CDATA[<div>Ugeskr Laeger. 2024 Apr 8;186(15):V10230679. doi: 10.61409/V10230679.ABSTRACTClavicle fractures are a common injury in adults. Most patients are treated non-operatively. In this case report, a 53-year-old professional violinist had a midt shaft clavicula fracture and was treated non-operatively. The fracture healed, but the patient developed thoracic outlet syndrome (TOS) and a venous thrombosis when playing violin. Surgery with restoration of the normal anatomy alleviated the symptoms and six months later she was symptom free and playing violin again. TOS is a rare complication to clavicle fractures and the treating doctors should be aware of the diagnosis.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38708702/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38708702</a> | DOI:<a href=https://doi.org/10.61409/V10230679>10.61409/V10230679</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38708702</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Pernille Henszelman Jørsboe</dc:creator>
<dc:creator>Anne Marie Nyholm</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Ugeskrift for laeger</dc:source>
<dc:title>Malunion of a clavicle fracture caused thoracic outlet syndrome in a professional violinist</dc:title>
<dc:identifier>pmid:38708702</dc:identifier>
<dc:identifier>doi:10.61409/V10230679</dc:identifier>
</item>
<item>
<title>The history of polio vaccination with "Sabin's OPV" 60 years after its introduction in Italy: an unforgivable "delay"</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38706758/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>In the spring of 1964, polio vaccination with the oral vaccine developed by Albert Sabin began in Italy. Polio was feared in the world and in Italy. Thus, between 1957 and the beginning of 1958, Italian children began receiving the "Salk vaccine", though the results were not particularly convincing. In July 1960, the international scientific community was able to verify the data from the mass testing of the Sabin vaccine. It became clear that the OPV, could prevent the virus from multiplying,...</description>
<content:encoded><![CDATA[<div>J Prev Med Hyg. 2024 Mar 31;65(1):E105-E112. doi: 10.15167/2421-4248/jpmh2024.65.1.3242. eCollection 2024 Mar.ABSTRACTIn the spring of 1964, polio vaccination with the oral vaccine developed by Albert Sabin began in Italy. Polio was feared in the world and in Italy. Thus, between 1957 and the beginning of 1958, Italian children began receiving the "Salk vaccine", though the results were not particularly convincing. In July 1960, the international scientific community was able to verify the data from the mass testing of the Sabin vaccine. It became clear that the OPV, could prevent the virus from multiplying, thereby providing greater protection and determining the eradication of the disease. In 1960 over 70 million people in the USSR alone had already received the oral vaccine and mass vaccination in the USA would start in March 1961. However, in Italy there was no similar initiative; only later the new vaccine was accepted but was not made compulsory at the beginning. As a result of the commission's report, registration of the "Polioral" vaccine, was authorized in September 1962 but the sale of the vaccine was not authorized until November 1963. At the beginning of 1964, the production of "Polioral" started and the product was marketed and on the 1 st of March 1964, anti-polio vaccination with the "Sabin anti-polio vaccine" also began in Italy. This manuscript focuses on a crucial issue about a historical delay for public health and it points out as the preparation and diffusion of the Sabin polio vaccine demonstrates that decisions regarding health treatments, and specifically vaccination campaigns, must be based exclusively on the results of clinical studies and on independent evaluation by the scientific community. This process ensures trust in vaccines, adequate protection of public health andcitizens' well-being.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38706758/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38706758</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11066819/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11066819</a> | DOI:<a href=https://doi.org/10.15167/2421-4248/jpmh2024.65.1.3242>10.15167/2421-4248/jpmh2024.65.1.3242</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38706758</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Davide Orsini</dc:creator>
<dc:creator>Lucia Valchi</dc:creator>
<dc:creator>Carola Minet</dc:creator>
<dc:creator>Mariano Martini</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Journal of preventive medicine and hygiene</dc:source>
<dc:title>The history of polio vaccination with "Sabin's OPV" 60 years after its introduction in Italy: an unforgivable "delay"</dc:title>
<dc:identifier>pmid:38706758</dc:identifier>
<dc:identifier>pmc:PMC11066819</dc:identifier>
<dc:identifier>doi:10.15167/2421-4248/jpmh2024.65.1.3242</dc:identifier>
</item>
<item>
<title>Screening for diabetic peripheral neuropathy at community pharmacies in Slovakia</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38706234/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>AIM: To identify diabetic patients with a potential risk of developing diabetic peripheral neuropathy (DPN) in community pharmacies in Slovakia using a modified Michigan Neuropathy Screening Instrument questionnaire (MNSIq-12).</description>
<content:encoded><![CDATA[<div>Croat Med J. 2024 Apr 30;65(2):85-92.ABSTRACTAIM: To identify diabetic patients with a potential risk of developing diabetic peripheral neuropathy (DPN) in community pharmacies in Slovakia using a modified Michigan Neuropathy Screening Instrument questionnaire (MNSIq-12).METHODS: This cross-sectional study enrolled 703 patients with type 1 and type 2 diabetes mellitus who had not been diagnosed with DPN. The study took place in selected community pharmacies across Slovakia in October 2019. The MNSIq-12 was administered by pharmacy students, and a Michigan score <1.5 was considered risky. The groups divided based on the Michigan score were compared in terms of duration of diabetes, age, body mass index (BMI), sex, weekly physical activity, level of education, and smoking.RESULTS: The risk of developing DPN was detected in 6.6% of respondents with type 1 diabetes and 13.4% with type 2 diabetes. Patients with both types of diabetes (38.2%; 67.0%) reported fatigue and heaviness in the legs as the most common clinical symptoms that may indicate the development of DPN. Those with a Michigan score <1.5 were older (P<0.0001), had a higher BMI (P<0.0001), a lower level of education (P=0.0020), and were less physically active (P<0.0001). Conclusion Approximately one-eighth of patients with diabetes who visited community pharmacies were potentially at risk for developing DPN. The modified MNSIq-12 was shown to be a simple, time-effective, and non-invasive indicative screening tool that can be applied in the environment of community pharmacies.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38706234/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38706234</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38706234</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Zuzana Pagáčová</dc:creator>
<dc:creator>Milan Grofik</dc:creator>
<dc:creator>Tomáš Fazekaš</dc:creator>
<dc:creator>Viera Žufková</dc:creator>
<dc:creator>Daniela Mináriková</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>Croatian medical journal</dc:source>
<dc:title>Screening for diabetic peripheral neuropathy at community pharmacies in Slovakia</dc:title>
<dc:identifier>pmid:38706234</dc:identifier>
</item>
<item>
<title>Medial Hoffa Fracture: A Case Report and Literature Review of Approach and Management</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38706183/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>BACKGROUND Hoffa fractures are an uncommon form of coronal fracture that impact the femoral condyle. As a result, they are not very prevalent. It is necessary to perform anatomical reduction and rigorous fixation on these fractures; however, there is no consensus among medical professionals on the surgical procedure and implant that would be the most successful in treating these fractures. CASE REPORT A 50-year-old woman who had poliomyelitis in her right lower limb presented with a displaced...</description>
<content:encoded><![CDATA[<div>Am J Case Rep. 2024 May 6;25:e943136. doi: 10.12659/AJCR.943136.ABSTRACTBACKGROUND Hoffa fractures are an uncommon form of coronal fracture that impact the femoral condyle. As a result, they are not very prevalent. It is necessary to perform anatomical reduction and rigorous fixation on these fractures; however, there is no consensus among medical professionals on the surgical procedure and implant that would be the most successful in treating these fractures. CASE REPORT A 50-year-old woman who had poliomyelitis in her right lower limb presented with a displaced medial Hoffa fracture of her left knee. She had fallen and was suffering from poliomyelitis. The trauma that caused this fracture had a modest energy level. Open reduction and internal fixation with 2 retrograde cannulated screws were included in her surgical procedure. An approach known as the medial parapatellar route was used for this treatment. As part of her postoperative rehabilitation, she participated in physiotherapy, exercises that did not require weight bearing, exercises that used passive and active assistance, activities that involved partial and full weight bearing, and exercises that involved complete weight bearing. At the 2-year follow-up, the patient's left knee continued to be painless and stable, and it had unrestricted range of motion across the whole extremity. It was determined via radiographs that the fracture had healed without any problems or arthritic changes developing. She was able to walk without help and carry out her daily tasks since she was able to walk with the use of a cane. CONCLUSIONS Retrograde cannulated screws can be a reliable and successful choice for treatment of medial Hoffa fractures, with positive results according to both clinical and radiographic characteristics. Further research is needed to analyze the outcomes over a longer period of time and make comparisons between this technique and others.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38706183/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38706183</a> | DOI:<a href=https://doi.org/10.12659/AJCR.943136>10.12659/AJCR.943136</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38706183</guid>
<pubDate>Mon, 06 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Alaa Akel</dc:creator>
<dc:creator>Mohammed Yahia Sarhan</dc:creator>
<dc:creator>Mohammad Abu-Jeyyab</dc:creator>
<dc:creator>Salah Tewfik Daradkeh</dc:creator>
<dc:creator>Suhaib Moseley</dc:creator>
<dc:creator>Mohammad Saeed Dawoud</dc:creator>
<dc:date>2024-05-06</dc:date>
<dc:source>The American journal of case reports</dc:source>
<dc:title>Medial Hoffa Fracture: A Case Report and Literature Review of Approach and Management</dc:title>
<dc:identifier>pmid:38706183</dc:identifier>
<dc:identifier>doi:10.12659/AJCR.943136</dc:identifier>
</item>
<item>
<title>Chinese expert consensus on the surgical treatment of neuropathic pain by the spinal cord dorsal root entry zone</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38706052/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>In order to promote the standardization of the treatment of neuropathic pain by spinal dorsal root entry surgery, alleviate the pain of certain specific neuropathic pain patients, and improve their quality of life and survival, experts with experience in neuropathic pain and spinal dorsal root entry surgery were organized by Functional Neurosurgery Group of the Neurosurgery Branch of the Chinese Medical Association and Functional Neurosurgery Expert Committee of Chinese Congress of Neurological...</description>
<content:encoded><![CDATA[<div>Zhonghua Yi Xue Za Zhi. 2024 May 7;104(17):1466-1473. doi: 10.3760/cma.j.cn112137-20231229-01508.ABSTRACTIn order to promote the standardization of the treatment of neuropathic pain by spinal dorsal root entry surgery, alleviate the pain of certain specific neuropathic pain patients, and improve their quality of life and survival, experts with experience in neuropathic pain and spinal dorsal root entry surgery were organized by Functional Neurosurgery Group of the Neurosurgery Branch of the Chinese Medical Association and Functional Neurosurgery Expert Committee of Chinese Congress of Neurological Surgeons to write this consensus. Based on a systematic review and summary of literature and clinical evidence at home and abroad, this consensus discusses the diagnosis and drug treatment of neuropathic pain, clinical application of, spinal dorsal root entry surgery the selection of patients receiving surgery of dorsal root entry zone, preoperative examination, surgical procedures, postoperative management, and the prevention and management of postoperative complications, and forms 12 recommended recommendations, providing reference and guidance for clinical work on the treatment of neuropathic pain through spinal dorsal root entry surgery.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38706052/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38706052</a> | DOI:<a href=https://doi.org/10.3760/cma.j.cn112137-20231229-01508>10.3760/cma.j.cn112137-20231229-01508</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38706052</guid>
<pubDate>Sun, 05 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Functional Neurosurgery Group of the Neurosurgery Branch of the Chinese Medical Association</dc:creator>
<dc:creator>Functional Neurosurgery Expert Committee of Chinese Congress of Neurological Surgeons</dc:creator>
<dc:date>2024-05-05</dc:date>
<dc:source>Zhonghua yi xue za zhi</dc:source>
<dc:title>Chinese expert consensus on the surgical treatment of neuropathic pain by the spinal cord dorsal root entry zone</dc:title>
<dc:identifier>pmid:38706052</dc:identifier>
<dc:identifier>doi:10.3760/cma.j.cn112137-20231229-01508</dc:identifier>
</item>
<item>
<title>Long-Term Comparative Efficacy and Safety of Risdiplam and Nusinersen in Children with Type 1 Spinal Muscular Atrophy</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38705943/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: Long-term data supported risdiplam as a superior alternative to nusinersen in children with type 1 SMA. Video abstract available for this article. Video abstract (MP4 184542 KB).</description>
<content:encoded><![CDATA[<div>Adv Ther. 2024 May 5. doi: 10.1007/s12325-024-02845-6. Online ahead of print.ABSTRACTINTRODUCTION: Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disease characterized by a loss of motor neurons and progressive muscle weakness. Children with untreated type 1 SMA never sit independently and require increasing levels of ventilatory support as the disease progresses. Without intervention, and lacking ventilatory support, death typically occurs before the age of 2 years. There are currently no head-to-head trials comparing available treatments in SMA. Indirect treatment comparisons are therefore needed to provide information on the relative efficacy and safety of SMA treatments for healthcare decision-making.METHODS: The long-term efficacy and safety of risdiplam versus nusinersen in children with type 1 SMA was evaluated using indirect treatment comparison methodology to adjust for differences between population baseline characteristics, to reduce any potential bias in the comparative analysis. An unanchored matching-adjusted indirect comparison was conducted using risdiplam data from 58 children in FIREFISH (NCT02913482) and published aggregate nusinersen data from 81 children obtained from the ENDEAR (NCT02193074) and SHINE (NCT02594124) clinical trials with at least 36 months of follow-up.RESULTS: Children with type 1 SMA treated with risdiplam had a 78% reduction in the rate of death, an 81% reduction in the rate of death or permanent ventilation, and a 57% reduction in the rate of serious adverse events compared with children treated with nusinersen. Children treated with risdiplam also had a 45% higher rate of achieving a Hammersmith Infant Neurological Examination, Module 2 motor milestone response and a 186% higher rate of achieving a ≥ 4-point improvement in Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders compared with children treated with nusinersen.CONCLUSION: Long-term data supported risdiplam as a superior alternative to nusinersen in children with type 1 SMA. Video abstract available for this article. Video abstract (MP4 184542 KB).PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38705943/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38705943</a> | DOI:<a href=https://doi.org/10.1007/s12325-024-02845-6>10.1007/s12325-024-02845-6</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38705943</guid>
<pubDate>Sun, 05 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Christos Kokaliaris</dc:creator>
<dc:creator>Rachel Evans</dc:creator>
<dc:creator>Neil Hawkins</dc:creator>
<dc:creator>Anadi Mahajan</dc:creator>
<dc:creator>David Alexander Scott</dc:creator>
<dc:creator>C Simone Sutherland</dc:creator>
<dc:creator>Julian Nam</dc:creator>
<dc:creator>Gautam Sajeev</dc:creator>
<dc:date>2024-05-05</dc:date>
<dc:source>Advances in therapy</dc:source>
<dc:title>Long-Term Comparative Efficacy and Safety of Risdiplam and Nusinersen in Children with Type 1 Spinal Muscular Atrophy</dc:title>
<dc:identifier>pmid:38705943</dc:identifier>
<dc:identifier>doi:10.1007/s12325-024-02845-6</dc:identifier>
</item>
<item>
<title>Pyomyositis in the sternocleidomastoid muscle in a previously healthy 36-year-old woman</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704724/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Pyomyositis is a bacterial infection of striated muscle, usually located to muscles in the extremities or pelvis. We present a microbiologically unique case report of pyomyositis in the sternocleidomastoid muscle (the first of its kind in Denmark) caused by Staphylococcus epidermidis, S. capitis and possibly Streptococcus pneumoniae. Pyomyositis is very rare but can lead to critical complications such as endocarditis and sepsis. It is therefore important to know the condition when evaluating an...</description>
<content:encoded><![CDATA[<div>Ugeskr Laeger. 2024 Apr 15;186(16):V11230750. doi: 10.61409/V11230750.ABSTRACTPyomyositis is a bacterial infection of striated muscle, usually located to muscles in the extremities or pelvis. We present a microbiologically unique case report of pyomyositis in the sternocleidomastoid muscle (the first of its kind in Denmark) caused by Staphylococcus epidermidis, S. capitis and possibly Streptococcus pneumoniae. Pyomyositis is very rare but can lead to critical complications such as endocarditis and sepsis. It is therefore important to know the condition when evaluating an infected patient with muscle pain. Treatment consists of antibiotics and - if relevant - surgical abscess drainage.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704724/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704724</a> | DOI:<a href=https://doi.org/10.61409/V11230750>10.61409/V11230750</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704724</guid>
<pubDate>Sun, 05 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jeppe Hjembæk-Brandt</dc:creator>
<dc:creator>Preben Homøe</dc:creator>
<dc:date>2024-05-05</dc:date>
<dc:source>Ugeskrift for laeger</dc:source>
<dc:title>Pyomyositis in the sternocleidomastoid muscle in a previously healthy 36-year-old woman</dc:title>
<dc:identifier>pmid:38704724</dc:identifier>
<dc:identifier>doi:10.61409/V11230750</dc:identifier>
</item>
<item>
<title>Systematic review of intermediate and long-term results of thoracic outlet decompression</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704189/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Thoracic outlet syndrome (TOS) consists of a group of disorders resulting from compression of the neurovascular bundle exiting through the thoracic outlet. TOS can be classified as follows based on the etiology of the pathophysiology: neurogenic TOS, venous TOS, arterial TOS, and mixed TOS. The constellation of symptoms a patient may experience varies, depending on the structures involved. Due to the wide range of etiologies and presenting symptoms, treatments for TOS also differ. Furthermore,...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):90-97. doi: 10.1053/j.semvascsurg.2024.01.001. Epub 2024 Jan 23.ABSTRACTThoracic outlet syndrome (TOS) consists of a group of disorders resulting from compression of the neurovascular bundle exiting through the thoracic outlet. TOS can be classified as follows based on the etiology of the pathophysiology: neurogenic TOS, venous TOS, arterial TOS, and mixed TOS. The constellation of symptoms a patient may experience varies, depending on the structures involved. Due to the wide range of etiologies and presenting symptoms, treatments for TOS also differ. Furthermore, most studies focus on the perioperative and short-term outcomes after surgical decompression for TOS. This systematic review aimed to provide a pooled analysis of studies to better understand the intermediate and long-term outcomes of surgical decompression for TOS. We conducted a systematic literature search in the Ovid MEDLINE, Embase, and Google Scholar databases for studies that analyzed long-term outcomes after surgical decompression for TOS. The inclusion period was from January 2015 to May 2023. The primary outcome was postoperative QuickDASH Outcome Measure scores. A total of 16 studies were included in the final analysis. The differences between postoperative and preoperative QuickDASH Outcome Measure scores were calculated, when possible, and there was a mean overall difference of 33.5 points (95% CI, 25.2-41.8; P = .001) after surgical decompression. There was a higher proportion of excellent outcomes reported for patients undergoing intervention for arterial and mixed TOS etiologies, whereas those with venous and neurogenic etiologies had the lowest proportion of excellent outcomes reported. Patients with neurogenic TOS had the highest proportion of poor outcomes reported. In conclusion, surgical decompression for TOS has favorable long-term outcomes, especially in patients with arterial and mixed etiologies.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704189/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704189</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.01.001>10.1053/j.semvascsurg.2024.01.001</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704189</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Mitri K Khoury</dc:creator>
<dc:creator>Micah A Thornton</dc:creator>
<dc:creator>Anahita Dua</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Systematic review of intermediate and long-term results of thoracic outlet decompression</dc:title>
<dc:identifier>pmid:38704189</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.01.001</dc:identifier>
</item>
<item>
<title>Video-assisted thoracic surgery and robotic-assisted first-rib excision and thoracic outlet syndrome decompression</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704188/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Multiple surgical approaches have been used in the management of thoracic outlet syndrome. These approaches have traditionally been "open" approaches and have been associated with the inherent morbidities of an open approach, including a risk of injury to the neurovascular structures due to traction and trauma while resecting the first rib. In addition, there has been concern that recurrence of symptoms may be related to incomplete resection of the rib with conventional open techniques. With the...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):82-89. doi: 10.1053/j.semvascsurg.2024.02.003. Epub 2024 Feb 16.ABSTRACTMultiple surgical approaches have been used in the management of thoracic outlet syndrome. These approaches have traditionally been "open" approaches and have been associated with the inherent morbidities of an open approach, including a risk of injury to the neurovascular structures due to traction and trauma while resecting the first rib. In addition, there has been concern that recurrence of symptoms may be related to incomplete resection of the rib with conventional open techniques. With the advent of minimally invasive thoracic surgery, surgeons began to explore first-rib resection via a thoracoscopic approach. Unfortunately, the existing video-assisted thoracic surgery technology and equipment was not well suited to working in the apex of the chest. With the introduction and subsequent progress in robotic surgery and instrumentation, this dissection can be performed with all the advantages of robotics, but also with minimal traction and trauma to the neurovascular structures, and incorporates almost complete resection of the rib with minimal residual stump. Robotics has developed as a reliable, safe, and less invasive approach to first-rib resection, yielding excellent results while limiting the morbidity of the procedure.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704188/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704188</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.02.003>10.1053/j.semvascsurg.2024.02.003</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704188</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Whitney Sutton</dc:creator>
<dc:creator>John O'Neill</dc:creator>
<dc:creator>Eric Strother</dc:creator>
<dc:creator>Danielle A Grossman</dc:creator>
<dc:creator>Ann E Hwalek</dc:creator>
<dc:creator>Marc Margolis</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Video-assisted thoracic surgery and robotic-assisted first-rib excision and thoracic outlet syndrome decompression</dc:title>
<dc:identifier>pmid:38704188</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.02.003</dc:identifier>
</item>
<item>
<title>The infraclavicular approach for venous thoracic outlet syndrome</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704187/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Venous thoracic outlet syndrome (vTOS) is an esoteric condition that presents in young, healthy adults. Treatment includes catheter-directed thrombolysis, followed by first-rib resection for decompression of the thoracic outlet. Various techniques for first-rib resection have been described with successful outcomes. The infraclavicular approach is well-suited to treat the most medial structures that are anatomically relevant for vTOS. A narrative review was conducted to specifically examine the...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):74-81. doi: 10.1053/j.semvascsurg.2024.01.003. Epub 2024 Jan 28.ABSTRACTVenous thoracic outlet syndrome (vTOS) is an esoteric condition that presents in young, healthy adults. Treatment includes catheter-directed thrombolysis, followed by first-rib resection for decompression of the thoracic outlet. Various techniques for first-rib resection have been described with successful outcomes. The infraclavicular approach is well-suited to treat the most medial structures that are anatomically relevant for vTOS. A narrative review was conducted to specifically examine the literature on infraclavicular exposure for vTOS. The technique for this operation is described, as well as the advantages and disadvantages of this approach. The infraclavicular approach is a reasonable choice for definitive treatment of uncomplicated vTOS.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704187/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704187</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.01.003>10.1053/j.semvascsurg.2024.01.003</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704187</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Sarah A Loh</dc:creator>
<dc:creator>Britt H Tonnessen</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>The infraclavicular approach for venous thoracic outlet syndrome</dc:title>
<dc:identifier>pmid:38704187</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.01.003</dc:identifier>
</item>
<item>
<title>Trans-axillary thoracic outlet decompression</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704186/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Thoracic outlet syndrome (TOS) is a group of conditions thought to be caused by the compression of neurovascular structures going to the upper extremity. TOS is a difficult disease to diagnose, and surgical treatment remains challenging. Many different surgical techniques for the treatment of TOS have been described in the literature and many reasonable to good outcomes have been reported, which makes it hard for surgeons to determine which techniques should be used. Our aim was to describe the...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):66-73. doi: 10.1053/j.semvascsurg.2024.02.006. Epub 2024 Mar 4.ABSTRACTThoracic outlet syndrome (TOS) is a group of conditions thought to be caused by the compression of neurovascular structures going to the upper extremity. TOS is a difficult disease to diagnose, and surgical treatment remains challenging. Many different surgical techniques for the treatment of TOS have been described in the literature and many reasonable to good outcomes have been reported, which makes it hard for surgeons to determine which techniques should be used. Our aim was to describe the rationale, techniques, and outcomes associated with the surgical treatment of TOS. Most patients in our center are treated primarily through a trans-axillary approach. We will elaborate on the technical details of performing trans-axillary thoracic outlet decompression. The essential steps during surgery are illustrated with videos. We focused on the idea behind performing a trans-axillary thoracic outlet decompression in primary cases. Institutional data on the outcomes of this surgical approach are described briefly.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704186/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704186</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.02.006>10.1053/j.semvascsurg.2024.02.006</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704186</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jens Goeteyn</dc:creator>
<dc:creator>Stijn B J Teijink</dc:creator>
<dc:creator>Niels Pesser</dc:creator>
<dc:creator>Marc R H M van Sambeek</dc:creator>
<dc:creator>Bart F L van Nuenen</dc:creator>
<dc:creator>Joep A W Teijink</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Trans-axillary thoracic outlet decompression</dc:title>
<dc:identifier>pmid:38704186</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.02.006</dc:identifier>
</item>
<item>
<title>The supraclavicular approach to decompression of the thoracic outlet</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704185/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Surgical decompression of the thoracic outlet, along with treatment of the involved nerve or vessel, is the accepted treatment modality when indicated. Although neurogenic thoracic outlet syndrome (TOS) is often operated via the axillary approach and venous TOS via the paraclavicular approach, arterial TOS is almost always operated via the supraclavicular approach. The supraclavicular approach provides excellent access to the artery, brachial plexus, phrenic nerve, and the cervical and/or first...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):57-65. doi: 10.1053/j.semvascsurg.2024.01.006. Epub 2024 Jan 26.ABSTRACTSurgical decompression of the thoracic outlet, along with treatment of the involved nerve or vessel, is the accepted treatment modality when indicated. Although neurogenic thoracic outlet syndrome (TOS) is often operated via the axillary approach and venous TOS via the paraclavicular approach, arterial TOS is almost always operated via the supraclavicular approach. The supraclavicular approach provides excellent access to the artery, brachial plexus, phrenic nerve, and the cervical and/or first ribs, along with any bony or fibrous or muscular abnormality that may be causing compression of the neurovascular structures. Even for neurogenic TOS, for which the axillary approach offers good cosmesis, the supraclavicular approach helps with adequate decompression while preserving the first rib. This approach may also be sufficient for thin patients with venous TOS. For arterial TOS, a supraclavicular incision usually suffices for excision of bony abnormality and repair of the subclavian artery.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704185/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704185</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.01.006>10.1053/j.semvascsurg.2024.01.006</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704185</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Prem Chand Gupta</dc:creator>
<dc:creator>Prajna B Kota</dc:creator>
<dc:creator>Vamsikrishna Yerramsetty</dc:creator>
<dc:creator>Velladuraichi Boologapandian</dc:creator>
<dc:creator>Viswanath Atreyapurapu</dc:creator>
<dc:creator>Pritee Sharma</dc:creator>
<dc:creator>Ajay Savlania</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>The supraclavicular approach to decompression of the thoracic outlet</dc:title>
<dc:identifier>pmid:38704185</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.01.006</dc:identifier>
</item>
<item>
<title>Management of thoracic outlet syndrome in patients with hemodialysis access</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704184/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Patients with threatened arteriovenous access are often found to have central venous stenoses at the ipsilateral costoclavicular junction, which may be resistant to endovascular intervention. Stenoses in this location may not resolve unless surgical decompression of thoracic outlet is performed to relieve the extrinsic compression on the subclavian vein. The authors reviewed the management of dialysis patients with central venous lesions at the thoracic outlet, as well as the role of surgical...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):50-56. doi: 10.1053/j.semvascsurg.2024.01.004. Epub 2024 Jan 22.ABSTRACTPatients with threatened arteriovenous access are often found to have central venous stenoses at the ipsilateral costoclavicular junction, which may be resistant to endovascular intervention. Stenoses in this location may not resolve unless surgical decompression of thoracic outlet is performed to relieve the extrinsic compression on the subclavian vein. The authors reviewed the management of dialysis patients with central venous lesions at the thoracic outlet, as well as the role of surgical decompression with first-rib resection or claviculectomy for salvage of threatened, ipsilateral dialysis access.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704184/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704184</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.01.004>10.1053/j.semvascsurg.2024.01.004</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704184</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Arash Fereydooni</dc:creator>
<dc:creator>Michael David Sgroi</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Management of thoracic outlet syndrome in patients with hemodialysis access</dc:title>
<dc:identifier>pmid:38704184</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.01.004</dc:identifier>
</item>
<item>
<title>Thoracic outlet syndrome in women</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704183/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Thoracic outlet syndrome (TOS) is observed more frequently in women, although the exact causes of this sex disparity remain unclear. By investigating the three types of TOS-arterial, neurogenic, and venous-regarding symptoms, diagnosis, and treatment, this article aims to shed light on the current understanding of TOS, focusing on its variations in women.</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):44-49. doi: 10.1053/j.semvascsurg.2024.01.002. Epub 2024 Feb 2.ABSTRACTThoracic outlet syndrome (TOS) is observed more frequently in women, although the exact causes of this sex disparity remain unclear. By investigating the three types of TOS-arterial, neurogenic, and venous-regarding symptoms, diagnosis, and treatment, this article aims to shed light on the current understanding of TOS, focusing on its variations in women.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704183/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704183</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.01.002>10.1053/j.semvascsurg.2024.01.002</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704183</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Grace Carvajal Mulatti</dc:creator>
<dc:creator>Marcelo Bellini Dalio</dc:creator>
<dc:creator>Tayrine Mazotti de Moraes</dc:creator>
<dc:creator>Gabriela Araújo Attie</dc:creator>
<dc:creator>André Brito-Queiroz</dc:creator>
<dc:creator>Edwaldo Edner Joviliano</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Thoracic outlet syndrome in women</dc:title>
<dc:identifier>pmid:38704183</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.01.002</dc:identifier>
</item>
<item>
<title>Diagnosis and management of thoracic outlet syndrome in athletes</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704182/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>The physical demands of sports can place patients at elevated risk of use-related pathologies, including thoracic outlet syndrome (TOS). Overhead athletes in particular (eg, baseball and football players, swimmers, divers, and weightlifters) often subject their subclavian vessels and brachial plexuses to repetitive trauma, resulting in venous effort thrombosis, arterial occlusions, brachial plexopathy, and more. This patient population is at higher risk for Paget-Schroetter syndrome, or effort...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):35-43. doi: 10.1053/j.semvascsurg.2024.01.007. Epub 2024 Feb 1.ABSTRACTThe physical demands of sports can place patients at elevated risk of use-related pathologies, including thoracic outlet syndrome (TOS). Overhead athletes in particular (eg, baseball and football players, swimmers, divers, and weightlifters) often subject their subclavian vessels and brachial plexuses to repetitive trauma, resulting in venous effort thrombosis, arterial occlusions, brachial plexopathy, and more. This patient population is at higher risk for Paget-Schroetter syndrome, or effort thrombosis, although neurogenic TOS (nTOS) is still the predominant form of the disease among all groups. First-rib resection is almost always recommended for vascular TOS in a young, active population, although a surgical benefit for patients with nTOS is less clear. Practitioners specializing in upper extremity disorders should take care to differentiate TOS from other repetitive use-related disorders, including shoulder orthopedic injuries and nerve entrapments at other areas of the neck and arm, as TOS is usually a diagnosis of exclusion. For nTOS, physical therapy is a cornerstone of diagnosis, along with response to injections. Most patients first undergo some period of nonoperative management with intense physical therapy and training before proceeding with rib resection. It is particularly essential for ensuring that athletes can return to their baselines of flexibility, strength, and stamina in the upper extremity. Botulinum toxin and lidocaine injections in the anterior scalene muscle might predict which patients will likely benefit from first-rib resection. Athletes are usually satisfied with their decisions to undergo first-rib resection, although the risk of rare but potentially career- or life-threatening complications, such as brachial plexus injury or subclavian vessel injury, must be considered. Frequently, they are able to return to the same or a higher level of play after full recovery.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704182/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704182</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.01.007>10.1053/j.semvascsurg.2024.01.007</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704182</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Andrea T Fisher</dc:creator>
<dc:creator>Jason T Lee</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Diagnosis and management of thoracic outlet syndrome in athletes</dc:title>
<dc:identifier>pmid:38704182</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.01.007</dc:identifier>
</item>
<item>
<title>Current concepts in clinical features and diagnosis of thoracic outlet syndrome</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704181/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>The diagnosis and clinical features of thoracic outlet syndrome have long confounded clinicians, owing to heterogeneity in symptom presentation and many overlapping competing diagnoses that are "more common." Despite the advent and prevalence of high-resolution imaging, along with the increasing awareness of the syndrome itself, misdiagnoses and untimely diagnoses can result in significant patient morbidity. The authors aimed to summarize the current concepts in the clinical features and...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):3-11. doi: 10.1053/j.semvascsurg.2024.01.005. Epub 2024 Jan 23.ABSTRACTThe diagnosis and clinical features of thoracic outlet syndrome have long confounded clinicians, owing to heterogeneity in symptom presentation and many overlapping competing diagnoses that are "more common." Despite the advent and prevalence of high-resolution imaging, along with the increasing awareness of the syndrome itself, misdiagnoses and untimely diagnoses can result in significant patient morbidity. The authors aimed to summarize the current concepts in the clinical features and diagnosis of thoracic outlet syndrome.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704181/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704181</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.01.005>10.1053/j.semvascsurg.2024.01.005</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704181</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Alexis Betancourt</dc:creator>
<dc:creator>Ehsan Benrashid</dc:creator>
<dc:creator>Prem Chand Gupta</dc:creator>
<dc:creator>Katharine L McGinigle</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Current concepts in clinical features and diagnosis of thoracic outlet syndrome</dc:title>
<dc:identifier>pmid:38704181</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.01.005</dc:identifier>
</item>
<item>
<title>Upper-limb neurovascular compression, pectoralis minor and quadrilateral space syndromes: A narrative review of current literature</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704180/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Pectoralis minor syndrome (PMS) and quadrilateral space syndrome (QSS) are uncommon neurovascular compression disorders affecting the upper extremity. PMS involves compression under the pectoralis minor muscle, and QSS results from compression in the quadrilateral space-both are classically observed in overhead-motion athletes. Diagnosing PMS and QSS may be challenging due to variable presentations and similarities with other, more common, upper-limb pathologies. Although there is no gold...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):26-34. doi: 10.1053/j.semvascsurg.2024.02.004. Epub 2024 Feb 16.ABSTRACTPectoralis minor syndrome (PMS) and quadrilateral space syndrome (QSS) are uncommon neurovascular compression disorders affecting the upper extremity. PMS involves compression under the pectoralis minor muscle, and QSS results from compression in the quadrilateral space-both are classically observed in overhead-motion athletes. Diagnosing PMS and QSS may be challenging due to variable presentations and similarities with other, more common, upper-limb pathologies. Although there is no gold standard diagnostic, local analgesic muscle-block response in a patient with the appropriate clinical context is often all that is required for an accurate diagnosis after excluding more common etiologies. Treatment ranges from conservative physical therapy to decompressive surgery, which is reserved for refractory cases or severe, acute vascular presentations. Decompression generally yields favorable outcomes, with most patients experiencing significant relief and restored baseline function. In conclusion, PMS and QSS, although rare, can cause debilitating upper-extremity symptoms; accurate diagnosis and appropriate treatment offer excellent outcomes, alleviating pain and disability.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704180/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704180</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.02.004>10.1053/j.semvascsurg.2024.02.004</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704180</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Peter N Drossopoulos</dc:creator>
<dc:creator>Colby Ruiz</dc:creator>
<dc:creator>Jonathan Mengistu</dc:creator>
<dc:creator>Charlotte B Smith</dc:creator>
<dc:creator>Luigi Pascarella</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Upper-limb neurovascular compression, pectoralis minor and quadrilateral space syndromes: A narrative review of current literature</dc:title>
<dc:identifier>pmid:38704180</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.02.004</dc:identifier>
</item>
<item>
<title>Neurogenic thoracic outlet syndrome and controversies in diagnosis and management</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704179/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Compression of the neurovascular structures at the level of the scalene triangle and pectoralis minor space is rare, but increasing awareness and understanding is allowing for the treatment of more individuals than in the past. We outlined the recognition, preoperative evaluation, and treatment of patients with neurogenic thoracic outlet syndrome. Recent work has illustrated the role of imaging and centrality of the physical examination on the diagnosis. However, a fuller understanding of the...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):20-25. doi: 10.1053/j.semvascsurg.2024.02.002. Epub 2024 Feb 19.ABSTRACTCompression of the neurovascular structures at the level of the scalene triangle and pectoralis minor space is rare, but increasing awareness and understanding is allowing for the treatment of more individuals than in the past. We outlined the recognition, preoperative evaluation, and treatment of patients with neurogenic thoracic outlet syndrome. Recent work has illustrated the role of imaging and centrality of the physical examination on the diagnosis. However, a fuller understanding of the spatial biomechanics of the shoulder, scalene triangle, and pectoralis minor musculotendinous complex has shown that, although physical therapy is a mainstay of treatment, a poor response to physical therapy with a sound diagnosis should not preclude decompression. Modes of failure of surgical decompression stress the importance of full resection of the anterior scalene muscle and all posterior rib impinging elements to minimize the risk of recurrence of symptoms. Neurogenic thoracic outlet syndrome is a rare but critical cause of disability of the upper extremity. Modern understanding of the pathophysiology and evaluation have led to a sounder diagnosis. Although physical therapy is a mainstay, surgical decompression remains the gold standard to preserve and recover function of the upper extremity. Understanding these principles will be central to further developments in the treatment of this patient population.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704179/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704179</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.02.002>10.1053/j.semvascsurg.2024.02.002</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704179</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Erin McIntosh</dc:creator>
<dc:creator>Ramesh K Tripathi</dc:creator>
<dc:creator>J Westley Ohman</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Neurogenic thoracic outlet syndrome and controversies in diagnosis and management</dc:title>
<dc:identifier>pmid:38704179</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.02.002</dc:identifier>
</item>
<item>
<title>A review of arterial thoracic outlet syndrome</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704178/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Arterial thoracic outlet syndrome (TOS) is a condition in which anatomic abnormalities in the thoracic outlet cause compression of the subclavian or, less commonly, axillary artery. Patients are usually younger and typically have an anatomic abnormality causing the compression. The condition usually goes undiagnosed until patients present with signs of acute or chronic hand or arm ischemia. Workup of this condition includes a thorough history and physical examination; chest x-ray to identify...</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):12-19. doi: 10.1053/j.semvascsurg.2024.02.001. Epub 2024 Feb 13.ABSTRACTArterial thoracic outlet syndrome (TOS) is a condition in which anatomic abnormalities in the thoracic outlet cause compression of the subclavian or, less commonly, axillary artery. Patients are usually younger and typically have an anatomic abnormality causing the compression. The condition usually goes undiagnosed until patients present with signs of acute or chronic hand or arm ischemia. Workup of this condition includes a thorough history and physical examination; chest x-ray to identify potential anatomic abnormalities; and arterial imaging, such as computed tomographic angiography or duplex to identify arterial abnormalities. Patients will usually require operative intervention, given their symptomatic presentation. Intervention should always include decompression of the thoracic outlet with at least a first-rib resection and any other structures causing external compression. If the artery is identified to have intimal damage, mural thrombus, or is aneurysmal, then arterial reconstruction is warranted. Stenting should be avoided due to external compression. In patients with symptoms of embolization, a combination of embolectomy, lytic catheter placement, and/or therapeutic anticoagulation should be done. Typically, patients have excellent outcomes, with resolution of symptoms and high patency of the bypass graft, although patients with distal embolization may require finger amputation.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704178/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704178</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.02.001>10.1053/j.semvascsurg.2024.02.001</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704178</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Vamsi K Potluri</dc:creator>
<dc:creator>Ruojia D Li</dc:creator>
<dc:creator>Paul Crisostomo</dc:creator>
<dc:creator>Carlos F Bechara</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>A review of arterial thoracic outlet syndrome</dc:title>
<dc:identifier>pmid:38704178</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.02.001</dc:identifier>
</item>
<item>
<title>Introduction and history of thoracic outlet syndrome</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38704177/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>No abstract</description>
<content:encoded><![CDATA[<div>Semin Vasc Surg. 2024 Mar;37(1):1-2. doi: 10.1053/j.semvascsurg.2024.02.005. Epub 2024 Feb 23.NO ABSTRACTPMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38704177/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38704177</a> | DOI:<a href=https://doi.org/10.1053/j.semvascsurg.2024.02.005>10.1053/j.semvascsurg.2024.02.005</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38704177</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Anahita Dua</dc:creator>
<dc:creator>Ramesh K Tripathi</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Seminars in vascular surgery</dc:source>
<dc:title>Introduction and history of thoracic outlet syndrome</dc:title>
<dc:identifier>pmid:38704177</dc:identifier>
<dc:identifier>doi:10.1053/j.semvascsurg.2024.02.005</dc:identifier>
</item>
<item>
<title>Could the motor unit number index be an early prognostic biomarker for amyotrophic lateral sclerosis?</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38703699/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: This longitudinal study suggests that MUNIX could be an early quantitative marker of disease progression and prognosis in ALS.</description>
<content:encoded><![CDATA[<div>Clin Neurophysiol. 2024 Apr 26;163:47-55. doi: 10.1016/j.clinph.2024.04.013. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the associations between motor unit number index (MUNIX) and disease progression and prognosis in amyotrophic lateral sclerosis (ALS) in a large-scale longitudinal study.METHODS: MUNIX was performed at the patient's first visit, at 3, 6, and 12 months in 4 muscles. MUNIX data from the patients were compared with those from 38 age-matched healthy controls. Clinical data included the revised ALS functional rating scale (ALSFRS-R), the forced vital capacity (FVC), and the survival of the patients.RESULTS: Eighty-two patients were included at baseline, 62 were evaluated at three months, 48 at six months, and 33 at twelve months. MUNIX score was lower in ALS patients compared to controls. At baseline, MUNIX was correlated with ALSFRS-R and FVC. Motor unit size index (MUSIX) was correlated with patient survival. Longitudinal analyses showed that MUNIX decline was greater than ALSFRS-R decline at each evaluation. A baseline MUNIX score greater than 378 predicted survival over the 12-month period with a sensitivity of 82% and a specificity of 56%.CONCLUSIONS: This longitudinal study suggests that MUNIX could be an early quantitative marker of disease progression and prognosis in ALS.SIGNIFICANCE: MUNIX might be considered as potential indicator for monitoring disease progression.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38703699/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38703699</a> | DOI:<a href=https://doi.org/10.1016/j.clinph.2024.04.013>10.1016/j.clinph.2024.04.013</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38703699</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Aude-Marie Grapperon</dc:creator>
<dc:creator>Vincent Harlay</dc:creator>
<dc:creator>Mohamed Boucekine</dc:creator>
<dc:creator>David Devos</dc:creator>
<dc:creator>Anne-Sophie Rolland</dc:creator>
<dc:creator>Claude Desnuelle</dc:creator>
<dc:creator>Emilien Delmont</dc:creator>
<dc:creator>Annie Verschueren</dc:creator>
<dc:creator>Shahram Attarian</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</dc:source>
<dc:title>Could the motor unit number index be an early prognostic biomarker for amyotrophic lateral sclerosis?</dc:title>
<dc:identifier>pmid:38703699</dc:identifier>
<dc:identifier>doi:10.1016/j.clinph.2024.04.013</dc:identifier>
</item>
<item>
<title>Effect of stiffness-optimized ankle foot orthoses on joint work in adults with neuromuscular diseases is related to severity of push-off deficits</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38703445/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>BACKGROUND: People with plantar flexor weakness generate less ankle push-off work during walking, resulting in inefficient proximal joint compensations. To increase push-off work, spring-like ankle foot orthoses (AFOs) can be provided. However, whether and in which patients AFOs increase push-off work and reduce compensatory hip and knee work is unknown.</description>
<content:encoded><![CDATA[<div>Gait Posture. 2024 May 3;111:162-168. doi: 10.1016/j.gaitpost.2024.04.034. Online ahead of print.ABSTRACTBACKGROUND: People with plantar flexor weakness generate less ankle push-off work during walking, resulting in inefficient proximal joint compensations. To increase push-off work, spring-like ankle foot orthoses (AFOs) can be provided. However, whether and in which patients AFOs increase push-off work and reduce compensatory hip and knee work is unknown.METHODS: In 18 people with bilateral plantar flexor weakness, we performed a 3D gait analysis at comfortable walking speed with shoes-only and with AFOs of which the stiffness was optimized. To account for walking speed differences between conditions, we compared relative joint work of the hip, knee and ankle joint. The relationships between relative work generated with shoes-only and changes in joint work with AFO were tested with Pearson correlations.RESULTS: No differences in relative ankle, knee and hip work over the gait cycle were found between shoes-only and AFO (p>0.499). Percentage of total ankle work generated during pre-swing increased with the AFO (AFO: 85.3±9.1% vs Shoes: 72.4±27.1%, p=0.026). At the hip, the AFO reduced relative work in pre-swing (AFO: 31.9±7.4% vs Shoes: 34.1±10.4%, p=0.038) and increased in loading response (AFO: 18.0±11.0% vs Shoes: 11.9±9.8%, p=0.022). Ankle work with shoes-only was inversely correlated with an increase in ankle work with AFO (r=-0.839, p<0.001) and this increase correlated with reduction in hip work with AFO (r=-0.650, p=0.004).DISCUSSION: Although stiffness-optimized AFOs did not alter the work distribution across the ankle, knee and hip joint compared to shoes-only walking, relative more ankle work was generated during push-off, causing a shift in hip work from pre-swing to loading response. Furthermore, larger ankle push-off deficits when walking with shoes-only were related with an increase in ankle work with AFO and reduction in compensatory hip work, indicating that more severely affected individuals benefit more from the energy storing-and-releasing capacity of AFOs.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38703445/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38703445</a> | DOI:<a href=https://doi.org/10.1016/j.gaitpost.2024.04.034>10.1016/j.gaitpost.2024.04.034</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38703445</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>N F J Waterval</dc:creator>
<dc:creator>F Nollet</dc:creator>
<dc:creator>M A Brehm</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Gait & posture</dc:source>
<dc:title>Effect of stiffness-optimized ankle foot orthoses on joint work in adults with neuromuscular diseases is related to severity of push-off deficits</dc:title>
<dc:identifier>pmid:38703445</dc:identifier>
<dc:identifier>doi:10.1016/j.gaitpost.2024.04.034</dc:identifier>
</item>
<item>
<title>Primary mitochondrial disorders and mimics: Insights from a large French cohort</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38703036/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>OBJECTIVE: The objective of this study was to evaluate the implementation of NGS within the French mitochondrial network, MitoDiag, from targeted gene panels to whole exome sequencing (WES) or whole genome sequencing (WGS) focusing on mitochondrial nuclear-encoded genes.</description>
<content:encoded><![CDATA[<div>Ann Clin Transl Neurol. 2024 May 4. doi: 10.1002/acn3.52062. Online ahead of print.ABSTRACTOBJECTIVE: The objective of this study was to evaluate the implementation of NGS within the French mitochondrial network, MitoDiag, from targeted gene panels to whole exome sequencing (WES) or whole genome sequencing (WGS) focusing on mitochondrial nuclear-encoded genes.METHODS: Over 2000 patients suspected of Primary Mitochondrial Diseases (PMD) were sequenced by either targeted gene panels, WES or WGS within MitoDiag. We described the clinical, biochemical, and molecular data of 397 genetically confirmed patients, comprising 294 children and 103 adults, carrying pathogenic or likely pathogenic variants in nuclear-encoded genes.RESULTS: The cohort exhibited a large genetic heterogeneity, with the identification of 172 distinct genes and 253 novel variants. Among children, a notable prevalence of pathogenic variants in genes associated with oxidative phosphorylation (OXPHOS) functions and mitochondrial translation was observed. In adults, pathogenic variants were primarily identified in genes linked to mtDNA maintenance. Additionally, a substantial proportion of patients (54% (42/78) and 48% (13/27) in children and adults, respectively), undergoing WES or WGS testing displayed PMD mimics, representing pathologies that clinically resemble mitochondrial diseases.INTERPRETATION: We reported the largest French cohort of patients suspected of PMD with pathogenic variants in nuclear genes. We have emphasized the clinical complexity of PMD and the challenges associated with recognizing and distinguishing them from other pathologies, particularly neuromuscular disorders. We confirmed that WES/WGS, instead of panel approach, was more valuable to identify the genetic basis in patients with "possible" PMD and we provided a genetic testing flowchart to guide physicians in their diagnostic strategy.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38703036/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38703036</a> | DOI:<a href=https://doi.org/10.1002/acn3.52062>10.1002/acn3.52062</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38703036</guid>
<pubDate>Sat, 04 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Cécile Rouzier</dc:creator>
<dc:creator>Emmanuelle Pion</dc:creator>
<dc:creator>Annabelle Chaussenot</dc:creator>
<dc:creator>Céline Bris</dc:creator>
<dc:creator>Samira Ait-El-Mkadem Saadi</dc:creator>
<dc:creator>Valérie Desquiret-Dumas</dc:creator>
<dc:creator>Naïg Gueguen</dc:creator>
<dc:creator>Konstantina Fragaki</dc:creator>
<dc:creator>Patrizia Amati-Bonneau</dc:creator>
<dc:creator>Giulia Barcia</dc:creator>
<dc:creator>Pauline Gaignard</dc:creator>
<dc:creator>Julie Steffann</dc:creator>
<dc:creator>Alessandra Pennisi</dc:creator>
<dc:creator>Jean-Paul Bonnefont</dc:creator>
<dc:creator>Elise Lebigot</dc:creator>
<dc:creator>Sylvie Bannwarth</dc:creator>
<dc:creator>Bruno Francou</dc:creator>
<dc:creator>Benoit Rucheton</dc:creator>
<dc:creator>Damien Sternberg</dc:creator>
<dc:creator>Marie-Laure Martin-Negrier</dc:creator>
<dc:creator>Aurélien Trimouille</dc:creator>
<dc:creator>Gaëlle Hardy</dc:creator>
<dc:creator>Stéphane Allouche</dc:creator>
<dc:creator>Cécile Acquaviva-Bourdain</dc:creator>
<dc:creator>Cécile Pagan</dc:creator>
<dc:creator>Anne-Sophie Lebre</dc:creator>
<dc:creator>Pascal Reynier</dc:creator>
<dc:creator>Mireille Cossee</dc:creator>
<dc:creator>Shahram Attarian</dc:creator>
<dc:creator>Véronique Paquis-Flucklinger</dc:creator>
<dc:creator>MitoDiag's Network Collaborators</dc:creator>
<dc:creator>Vincent Procaccio</dc:creator>
<dc:date>2024-05-04</dc:date>
<dc:source>Annals of clinical and translational neurology</dc:source>
<dc:title>Primary mitochondrial disorders and mimics: Insights from a large French cohort</dc:title>
<dc:identifier>pmid:38703036</dc:identifier>
<dc:identifier>doi:10.1002/acn3.52062</dc:identifier>
</item>
<item>
<title>Functional connectivity associated with attention networks differs among subgroups of fibromyalgia patients: an observational case-control study</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38702506/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Fibromyalgia is a heterogenous chronic pain disorder diagnosed by symptom-based criteria. The aim of this study was to clarify different pathophysiological characteristics between subgroups of patients with fibromyalgia. We identified subgroups with distinct pain thresholds: those with a low pressure pain threshold (PL; 16 patients) and those with a normal pressure pain threshold (PN; 15 patients). Both groups experienced severe pain. We performed resting-state functional MRI analysis and...</description>
<content:encoded><![CDATA[<div>Sci Rep. 2024 May 3;14(1):10197. doi: 10.1038/s41598-024-60993-9.ABSTRACTFibromyalgia is a heterogenous chronic pain disorder diagnosed by symptom-based criteria. The aim of this study was to clarify different pathophysiological characteristics between subgroups of patients with fibromyalgia. We identified subgroups with distinct pain thresholds: those with a low pressure pain threshold (PL; 16 patients) and those with a normal pressure pain threshold (PN; 15 patients). Both groups experienced severe pain. We performed resting-state functional MRI analysis and detected 11 functional connectivity pairs among all 164 ROIs with distinct difference between the two groups (p < 0.001). The most distinctive one was that the PN group had significantly higher functional connectivity between the secondary somatosensory area and the dorsal attention network (p < 0.0001). Then, we investigated the transmission pathway of pain stimuli. Functional connectivity of the thalamus to the insular cortex was significantly higher in the PL group (p < 0.01 - 0.05). These results suggest that endogenous pain driven by top-down signals via the dorsal attention network may contribute to pain sensation in a subgroup of fibromyalgia patients with a normal pain threshold. Besides, external pain driven by bottom-up signals via the spinothalamic tract may contribute to pain sensations in another group of patients with a low pain threshold. Trial registration: UMIN000037712.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38702506/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38702506</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11068894/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11068894</a> | DOI:<a href=https://doi.org/10.1038/s41598-024-60993-9>10.1038/s41598-024-60993-9</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38702506</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Tomohiko Aoe</dc:creator>
<dc:creator>Ryoko Kawanaka</dc:creator>
<dc:creator>Fumio Ohsone</dc:creator>
<dc:creator>Akira Hara</dc:creator>
<dc:creator>Tokuzo Yokokawa</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Scientific reports</dc:source>
<dc:title>Functional connectivity associated with attention networks differs among subgroups of fibromyalgia patients: an observational case-control study</dc:title>
<dc:identifier>pmid:38702506</dc:identifier>
<dc:identifier>pmc:PMC11068894</dc:identifier>
<dc:identifier>doi:10.1038/s41598-024-60993-9</dc:identifier>
</item>
<item>
<title>Severe cardiac and skeletal manifestations in DMD-edited microminipigs: an advanced surrogate for Duchenne muscular dystrophy</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38702481/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Duchenne muscular dystrophy (DMD) is an intractable X-linked muscular dystrophy caused by mutations in the DMD gene. While many animal models have been used to study the disease, translating findings to humans has been challenging. Microminipigs, with their pronounced physiological similarity to humans and notably compact size amongst pig models, could offer a more representative model for human diseases. Here, we accomplished precise DMD modification in microminipigs by co-injecting embryos...</description>
<content:encoded><![CDATA[<div>Commun Biol. 2024 May 3;7(1):523. doi: 10.1038/s42003-024-06222-5.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked muscular dystrophy caused by mutations in the DMD gene. While many animal models have been used to study the disease, translating findings to humans has been challenging. Microminipigs, with their pronounced physiological similarity to humans and notably compact size amongst pig models, could offer a more representative model for human diseases. Here, we accomplished precise DMD modification in microminipigs by co-injecting embryos with Cas9 protein and a single-guide RNA targeting exon 23 of DMD. The DMD-edited microminipigs exhibited pronounced clinical phenotypes, including perturbed locomotion and body-wide skeletal muscle weakness and atrophy, alongside augmented serum creatine kinase levels. Muscle weakness was observed as of one month of age, respiratory and cardiac dysfunctions emerged by the sixth month, and the maximum lifespan was 29.9 months. Histopathological evaluations confirmed dystrophin deficiency and pronounced dystrophic pathology in the skeletal and myocardial tissues, demonstrating that these animals are an unprecedented model for studying human DMD. The model stands as a distinct and crucial tool in biomedical research, offering deep understanding of disease progression and enhancing therapeutic assessments, with potential to influence forthcoming treatment approaches.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38702481/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38702481</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11068776/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11068776</a> | DOI:<a href=https://doi.org/10.1038/s42003-024-06222-5>10.1038/s42003-024-06222-5</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38702481</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Masayoshi Otake</dc:creator>
<dc:creator>Michihiro Imamura</dc:creator>
<dc:creator>Satoko Enya</dc:creator>
<dc:creator>Akihisa Kangawa</dc:creator>
<dc:creator>Masatoshi Shibata</dc:creator>
<dc:creator>Kinuyo Ozaki</dc:creator>
<dc:creator>Koichi Kimura</dc:creator>
<dc:creator>Etsuro Ono</dc:creator>
<dc:creator>Yoshitsugu Aoki</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Communications biology</dc:source>
<dc:title>Severe cardiac and skeletal manifestations in DMD-edited microminipigs: an advanced surrogate for Duchenne muscular dystrophy</dc:title>
<dc:identifier>pmid:38702481</dc:identifier>
<dc:identifier>pmc:PMC11068776</dc:identifier>
<dc:identifier>doi:10.1038/s42003-024-06222-5</dc:identifier>
</item>
<item>
<title>Utility of next generation sequencing in paediatric neurological disorders: experience from South Africa</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38702429/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Next generation sequencing (NGS)-based tests have become routine first-line investigative modalities in paediatric neurology clinics in many high-income countries (HICs). Studies from these countries show that these tests are both cost-effective and reliable in diagnosing many complex childhood neurological diseases. However, NGS-based testing in low-and middle-income countries (LMICs) is limited due to affordability constraints. The primary objective of this study was to evaluate the diagnostic...</description>
<content:encoded><![CDATA[<div>Eur J Hum Genet. 2024 May 3. doi: 10.1038/s41431-024-01582-2. Online ahead of print.ABSTRACTNext generation sequencing (NGS)-based tests have become routine first-line investigative modalities in paediatric neurology clinics in many high-income countries (HICs). Studies from these countries show that these tests are both cost-effective and reliable in diagnosing many complex childhood neurological diseases. However, NGS-based testing in low-and middle-income countries (LMICs) is limited due to affordability constraints. The primary objective of this study was to evaluate the diagnostic yield and impact of targeted gene panel sequencing in a selected paediatric cohort attending a tertiary paediatric neurology clinic in the Western Cape Province of South Africa. This retrospective study included 124 consecutive paediatric patients with neurological disease, aged 6 weeks to 17 years, referred for NGS-based multi-gene panel testing over a 41-month period. Twenty-four different disease group-specific panels were utilized. A caregiver experience questionnaire was administered when a pathogenic variant was identified. The overall study diagnostic yield (DY) was 45% (56/124 patients). The diagnostic yield in this study is similar to previously reported paediatric cohorts in HICs. The high yields for neuromuscular disorders (52%) and early epileptic encephalopathies (41%) suggest that NGS-based panels may be more cost-effective as first-line testing in well-defined phenotypes. The latter finding argues for early inclusion of all children with developmental epileptic encephalopathies (DEE), as early diagnosis leads to better treatment and avoidance of unnecessary investigations.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38702429/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38702429</a> | DOI:<a href=https://doi.org/10.1038/s41431-024-01582-2>10.1038/s41431-024-01582-2</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38702429</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Magriet van Niekerk</dc:creator>
<dc:creator>Shahida Moosa</dc:creator>
<dc:creator>Ronald van Toorn</dc:creator>
<dc:creator>Regan Solomons</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>European journal of human genetics : EJHG</dc:source>
<dc:title>Utility of next generation sequencing in paediatric neurological disorders: experience from South Africa</dc:title>
<dc:identifier>pmid:38702429</dc:identifier>
<dc:identifier>doi:10.1038/s41431-024-01582-2</dc:identifier>
</item>
<item>
<title>Factors influencing the outcomes of non-pharmacological interventions for managing fatigue across the lifespan of people living with musculoskeletal (MSK) conditions: a scoping review protocol</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38702081/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>INTRODUCTION: Fatigue is an important and distressing symptom for many people living with chronic musculoskeletal (MSK) conditions. Many non-pharmacological interventions have been investigated in recent years and some have been demonstrated to be effective in reducing fatigue and fatigue impact, however, there is limited guidance for clinicians to follow regarding the most appropriate management options. The objective of this scoping review is to understand and map the extent of evidence in...</description>
<content:encoded><![CDATA[<div>BMJ Open. 2024 May 3;14(5):e082555. doi: 10.1136/bmjopen-2023-082555.ABSTRACTINTRODUCTION: Fatigue is an important and distressing symptom for many people living with chronic musculoskeletal (MSK) conditions. Many non-pharmacological interventions have been investigated in recent years and some have been demonstrated to be effective in reducing fatigue and fatigue impact, however, there is limited guidance for clinicians to follow regarding the most appropriate management options. The objective of this scoping review is to understand and map the extent of evidence in relation to the factors that relate to the outcome of non-pharmacological interventions on MSK condition-related fatigue across the lifespan.METHODS AND ANALYSIS: This scoping review will include evidence relating to people of all ages living with chronic MSK conditions who have been offered a non-pharmacological intervention with either the intention or effect of reducing fatigue and its impact. Databases including AMED, PsycINFO, CINAHLPlus, MEDLINE, EMBASE and Scopus will be searched for peer-reviewed primary research studies published after 1 January 2007 in English language. These findings will be used to identify factors associated with successful interventions and to map gaps in knowledge.ETHICS AND DISSEMINATION: Ethical approval was not required for this review. Findings will be disseminated by journal publications, conference presentations and by communicating with relevant healthcare and charity organisations.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38702081/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38702081</a> | DOI:<a href=https://doi.org/10.1136/bmjopen-2023-082555>10.1136/bmjopen-2023-082555</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38702081</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Katie Fishpool</dc:creator>
<dc:creator>George Young</dc:creator>
<dc:creator>Coziana Ciurtin</dc:creator>
<dc:creator>Fiona Cramp</dc:creator>
<dc:creator>Emmanuel Oghenetejiri Erhieyovwe</dc:creator>
<dc:creator>Bayram Farisogullari</dc:creator>
<dc:creator>Gary J Macfarlane</dc:creator>
<dc:creator>Pedro M Machado</dc:creator>
<dc:creator>Jen Pearson</dc:creator>
<dc:creator>Eduardo Santos</dc:creator>
<dc:creator>Emma Dures</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>BMJ open</dc:source>
<dc:title>Factors influencing the outcomes of non-pharmacological interventions for managing fatigue across the lifespan of people living with musculoskeletal (MSK) conditions: a scoping review protocol</dc:title>
<dc:identifier>pmid:38702081</dc:identifier>
<dc:identifier>doi:10.1136/bmjopen-2023-082555</dc:identifier>
</item>
<item>
<title>Successful surgical excision of a melanoma and a rare peripheral nerve sheath tumor in 2 cattle</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701801/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>A heifer and a dairy cow were presented to our practice with cutaneous masses on the left side of their necks. Each mass had a diameter of approximately 20 cm. Both tumors had increased in size in recent weeks and were now prone to injuries from the stable equipment. Both animal owners agreed to surgical removal, which was performed under sedation and local anesthesia on a bovine treatment crush. The subsequent histopathological examinations of the extirpates revealed a melanocytoma in the young...</description>
<content:encoded><![CDATA[<div>Tierarztl Prax Ausg G Grosstiere Nutztiere. 2024 Apr;52(2):101-107. doi: 10.1055/a-2283-9614. Epub 2024 May 3.ABSTRACTA heifer and a dairy cow were presented to our practice with cutaneous masses on the left side of their necks. Each mass had a diameter of approximately 20 cm. Both tumors had increased in size in recent weeks and were now prone to injuries from the stable equipment. Both animal owners agreed to surgical removal, which was performed under sedation and local anesthesia on a bovine treatment crush. The subsequent histopathological examinations of the extirpates revealed a melanocytoma in the young heifer and a cutaneous peripheral nerve sheath tumor (PNST) in the dairy cow. Both cases were benign tumors. The postoperative course was without complications and no recurrences were observed even more than a year later. No comparable tumors were found in related animals or in the offspring.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701801/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701801</a> | DOI:<a href=https://doi.org/10.1055/a-2283-9614>10.1055/a-2283-9614</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701801</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Marie-Theres Schrenk</dc:creator>
<dc:creator>Christoph Wenzel</dc:creator>
<dc:creator>Kathrin Jäger</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere</dc:source>
<dc:title>Successful surgical excision of a melanoma and a rare peripheral nerve sheath tumor in 2 cattle</dc:title>
<dc:identifier>pmid:38701801</dc:identifier>
<dc:identifier>doi:10.1055/a-2283-9614</dc:identifier>
</item>
<item>
<title>Genome sequence analyses identify novel risk loci for multiple system atrophy</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701790/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is poorly understood, and treatments are limited to supportive measures. Here, we performed a comprehensive analysis of whole genome sequence data from 888 European-ancestry MSA cases and 7,128 controls to systematically investigate the genetic underpinnings of this understudied neurodegenerative disease. We identified four...</description>
<content:encoded><![CDATA[<div>Neuron. 2024 Apr 24:S0896-6273(24)00240-X. doi: 10.1016/j.neuron.2024.04.002. Online ahead of print.ABSTRACTMultiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is poorly understood, and treatments are limited to supportive measures. Here, we performed a comprehensive analysis of whole genome sequence data from 888 European-ancestry MSA cases and 7,128 controls to systematically investigate the genetic underpinnings of this understudied neurodegenerative disease. We identified four significantly associated risk loci using a genome-wide association study approach. Transcriptome-wide association analyses prioritized USP38-DT, KCTD7, and lnc-KCTD7-2 as novel susceptibility genes for MSA within these loci, and single-nucleus RNA sequence analysis found that the associated variants acted as cis-expression quantitative trait loci for multiple genes across neuronal and glial cell types. In conclusion, this study highlights the role of genetic determinants in the pathogenesis of MSA, and the publicly available data from this study represent a valuable resource for investigating synucleinopathies.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701790/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701790</a> | DOI:<a href=https://doi.org/10.1016/j.neuron.2024.04.002>10.1016/j.neuron.2024.04.002</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701790</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Ruth Chia</dc:creator>
<dc:creator>Anindita Ray</dc:creator>
<dc:creator>Zalak Shah</dc:creator>
<dc:creator>Jinhui Ding</dc:creator>
<dc:creator>Paola Ruffo</dc:creator>
<dc:creator>Masashi Fujita</dc:creator>
<dc:creator>Vilas Menon</dc:creator>
<dc:creator>Sara Saez-Atienzar</dc:creator>
<dc:creator>Paolo Reho</dc:creator>
<dc:creator>Karri Kaivola</dc:creator>
<dc:creator>Ronald L Walton</dc:creator>
<dc:creator>Regina H Reynolds</dc:creator>
<dc:creator>Ramita Karra</dc:creator>
<dc:creator>Shaimaa Sait</dc:creator>
<dc:creator>Fulya Akcimen</dc:creator>
<dc:creator>Monica Diez-Fairen</dc:creator>
<dc:creator>Ignacio Alvarez</dc:creator>
<dc:creator>Alessandra Fanciulli</dc:creator>
<dc:creator>Nadia Stefanova</dc:creator>
<dc:creator>Klaus Seppi</dc:creator>
<dc:creator>Susanne Duerr</dc:creator>
<dc:creator>Fabian Leys</dc:creator>
<dc:creator>Florian Krismer</dc:creator>
<dc:creator>Victoria Sidoroff</dc:creator>
<dc:creator>Alexander Zimprich</dc:creator>
<dc:creator>Walter Pirker</dc:creator>
<dc:creator>Olivier Rascol</dc:creator>
<dc:creator>Alexandra Foubert-Samier</dc:creator>
<dc:creator>Wassilios G Meissner</dc:creator>
<dc:creator>François Tison</dc:creator>
<dc:creator>Anne Pavy-Le Traon</dc:creator>
<dc:creator>Maria Teresa Pellecchia</dc:creator>
<dc:creator>Paolo Barone</dc:creator>
<dc:creator>Maria Claudia Russillo</dc:creator>
<dc:creator>Juan Marín-Lahoz</dc:creator>
<dc:creator>Jaime Kulisevsky</dc:creator>
<dc:creator>Soraya Torres</dc:creator>
<dc:creator>Pablo Mir</dc:creator>
<dc:creator>Maria Teresa Periñán</dc:creator>
<dc:creator>Christos Proukakis</dc:creator>
<dc:creator>Viorica Chelban</dc:creator>
<dc:creator>Lesley Wu</dc:creator>
<dc:creator>Yee Y Goh</dc:creator>
<dc:creator>Laura Parkkinen</dc:creator>
<dc:creator>Michele T Hu</dc:creator>
<dc:creator>Christopher Kobylecki</dc:creator>
<dc:creator>Jennifer A Saxon</dc:creator>
<dc:creator>Sara Rollinson</dc:creator>
<dc:creator>Emily Garland</dc:creator>
<dc:creator>Italo Biaggioni</dc:creator>
<dc:creator>Irene Litvan</dc:creator>
<dc:creator>Ileana Rubio</dc:creator>
<dc:creator>Roy N Alcalay</dc:creator>
<dc:creator>Kimberly T Kwei</dc:creator>
<dc:creator>Steven J Lubbe</dc:creator>
<dc:creator>Qinwen Mao</dc:creator>
<dc:creator>Margaret E Flanagan</dc:creator>
<dc:creator>Rudolph J Castellani</dc:creator>
<dc:creator>Vikram Khurana</dc:creator>
<dc:creator>Alain Ndayisaba</dc:creator>
<dc:creator>Andrea Calvo</dc:creator>
<dc:creator>Gabriele Mora</dc:creator>
<dc:creator>Antonio Canosa</dc:creator>
<dc:creator>Gianluca Floris</dc:creator>
<dc:creator>Ryan C Bohannan</dc:creator>
<dc:creator>Anni Moore</dc:creator>
<dc:creator>Lucy Norcliffe-Kaufmann</dc:creator>
<dc:creator>Jose-Alberto Palma</dc:creator>
<dc:creator>Horacio Kaufmann</dc:creator>
<dc:creator>Changyoun Kim</dc:creator>
<dc:creator>Michiyo Iba</dc:creator>
<dc:creator>Eliezer Masliah</dc:creator>
<dc:creator>Ted M Dawson</dc:creator>
<dc:creator>Liana S Rosenthal</dc:creator>
<dc:creator>Alexander Pantelyat</dc:creator>
<dc:creator>Marilyn S Albert</dc:creator>
<dc:creator>Olga Pletnikova</dc:creator>
<dc:creator>Juan C Troncoso</dc:creator>
<dc:creator>Jon Infante</dc:creator>
<dc:creator>Carmen Lage</dc:creator>
<dc:creator>Pascual Sánchez-Juan</dc:creator>
<dc:creator>Geidy E Serrano</dc:creator>
<dc:creator>Thomas G Beach</dc:creator>
<dc:creator>Pau Pastor</dc:creator>
<dc:creator>Huw R Morris</dc:creator>
<dc:creator>Diego Albani</dc:creator>
<dc:creator>Jordi Clarimon</dc:creator>
<dc:creator>Gregor K Wenning</dc:creator>
<dc:creator>John A Hardy</dc:creator>
<dc:creator>Mina Ryten</dc:creator>
<dc:creator>Eric Topol</dc:creator>
<dc:creator>Ali Torkamani</dc:creator>
<dc:creator>Adriano Chiò</dc:creator>
<dc:creator>David A Bennett</dc:creator>
<dc:creator>Philip L De Jager</dc:creator>
<dc:creator>Philip A Low</dc:creator>
<dc:creator>Wolfgang Singer</dc:creator>
<dc:creator>William P Cheshire</dc:creator>
<dc:creator>Zbigniew K Wszolek</dc:creator>
<dc:creator>Dennis W Dickson</dc:creator>
<dc:creator>Bryan J Traynor</dc:creator>
<dc:creator>J Raphael Gibbs</dc:creator>
<dc:creator>Clifton L Dalgard</dc:creator>
<dc:creator>Owen A Ross</dc:creator>
<dc:creator>Henry Houlden</dc:creator>
<dc:creator>Sonja W Scholz</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Neuron</dc:source>
<dc:title>Genome sequence analyses identify novel risk loci for multiple system atrophy</dc:title>
<dc:identifier>pmid:38701790</dc:identifier>
<dc:identifier>doi:10.1016/j.neuron.2024.04.002</dc:identifier>
</item>
<item>
<title>Superacute onset of Guillain-Barré syndrome after elective spinal surgery: A case report and literature review</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701319/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>RATIONALE: Guillain-Barré syndrome (GBS) epitomizes an acute peripheral neuropathy hallmarked by an autoimmune retort directed at the myelin sheath enwrapping peripheral nerves. While it is widely acknowledged that a majority of GBS patients boast a history of antecedent infections, the documentation of postoperative GBS occurrences is progressively mounting. Drawing upon an exhaustive compendium of recent case reports, the disease's inception spans a gamut from within 1 hour to 1.2 years.</description>
<content:encoded><![CDATA[<div>Medicine (Baltimore). 2024 May 3;103(18):e37925. doi: 10.1097/MD.0000000000037925.ABSTRACTRATIONALE: Guillain-Barré syndrome (GBS) epitomizes an acute peripheral neuropathy hallmarked by an autoimmune retort directed at the myelin sheath enwrapping peripheral nerves. While it is widely acknowledged that a majority of GBS patients boast a history of antecedent infections, the documentation of postoperative GBS occurrences is progressively mounting. Drawing upon an exhaustive compendium of recent case reports, the disease's inception spans a gamut from within 1 hour to 1.2 years.PATIENT CONCERNS: At this juncture, we proffer a singular case: an instance involving a 51-year-old gentleman who underwent lumbar spine surgery, only to encounter immediate debilitation of limb and respiratory musculature.DIAGNOSES: Post elimination of variables linked to anesthetic agents, encephalon, and spinal cord pathologies, a potent suspicion of superacute GBS onset emerged.INTERVENTIONS: Subsequent to immunoglobulin therapy, plasmapheresis, and adjunctive support, the patient's ultimate demise became manifest.OUTCOMES: No progress was found to date.LESSONS: Given GBS's potential to instigate paralysis, respiratory collapse, and autonomic nervous system aberrations, alongside other pernicious sequelae, coupled with the exceptional rarity of the temporal onset in this particular instance, it undeniably proffers an imposing conundrum for anesthetists in the realm of differential diagnosis and therapeutic conduct. During the postoperative convalescence phase under anesthesia, should the patient evince deviant limb musculature vigor and compromised respiratory sinews, the prospect of GBS must not be consigned to oblivion. Precision in diagnosis conjoined with apt therapeutic measures could well be the harbinger of a divergent denouement for the afflicted patient.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701319/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701319</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11062723/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11062723</a> | DOI:<a href=https://doi.org/10.1097/MD.0000000000037925>10.1097/MD.0000000000037925</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701319</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Xinyu Zhang</dc:creator>
<dc:creator>Deshui Yu</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Medicine</dc:source>
<dc:title>Superacute onset of Guillain-Barré syndrome after elective spinal surgery: A case report and literature review</dc:title>
<dc:identifier>pmid:38701319</dc:identifier>
<dc:identifier>pmc:PMC11062723</dc:identifier>
<dc:identifier>doi:10.1097/MD.0000000000037925</dc:identifier>
</item>
<item>
<title>Research trends on acupuncture for neuropathic pain: A bibliometric analysis from 1979 to 2023</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701301/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: This present study visually showed the research status and trends of acupuncture for NP from 1979 to 2023 on the basis of bibliometric analysis, which may in some way help researcher discovery and explore some new research directions and ideas in the future.</description>
<content:encoded><![CDATA[<div>Medicine (Baltimore). 2024 May 3;103(18):e37962. doi: 10.1097/MD.0000000000037962.ABSTRACTBACKGROUND: Acupuncture has drawn increasing attention as a complementary and alternative therapy for neuropathic pain (NP). The present study aimed to summarize the current status and research trends on acupuncture for NP over the past several decades.METHODS: The publications on acupuncture for NP in the database of Web of Science Core Collection from 1979 to 2023 were searched. VOSviewer (1.6.15) and CiteSpace software (5.5.R2) were applied to identify active authors, journals, countries and institutions, co-cited references and hot keywords.RESULTS: A total of 642 publications were finally included, and the quantitative trend of annual publications on acupuncture for NP have shown overall upward from 1979 to 2023. Peoples R China was the most productive and influential country, while Kyung Hee University from South Korea was both the first in publications and citations. Fang JQ ranked the first productive author and Han JS was the first 1 among the co-cited authors. The first productive journal was Evidence-based Complementary and Alternative Medicine, while the first co-cited journal was Pain. The high-frequency keywords were divided into 9 clusters, and the frontier topic focused on "Chronic pain".CONCLUSION: This present study visually showed the research status and trends of acupuncture for NP from 1979 to 2023 on the basis of bibliometric analysis, which may in some way help researcher discovery and explore some new research directions and ideas in the future.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701301/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701301</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11062671/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11062671</a> | DOI:<a href=https://doi.org/10.1097/MD.0000000000037962>10.1097/MD.0000000000037962</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701301</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Tao Li</dc:creator>
<dc:creator>Qilu Yan</dc:creator>
<dc:creator>Wei Huang</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Medicine</dc:source>
<dc:title>Research trends on acupuncture for neuropathic pain: A bibliometric analysis from 1979 to 2023</dc:title>
<dc:identifier>pmid:38701301</dc:identifier>
<dc:identifier>pmc:PMC11062671</dc:identifier>
<dc:identifier>doi:10.1097/MD.0000000000037962</dc:identifier>
</item>
<item>
<title>Identification and validation of oxidative stress-related genes in sepsis-induced myopathy</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701300/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: The results of this study suggest that OS-genes might play an important role in SIM. CD36, GPX3, NQO1, GSR, and TP53 have potential as specific biomarkers for the diagnosis of SIM.</description>
<content:encoded><![CDATA[<div>Medicine (Baltimore). 2024 May 3;103(18):e37933. doi: 10.1097/MD.0000000000037933.ABSTRACTBACKGROUND: Sepsis-induced myopathy (SIM) a complication of sepsis that results in prolonged mechanical ventilation, long-term functional disability, and increased patient mortality. This study was performed to identify potential key oxidative stress-related genes (OS-genes) as biomarkers for the diagnosis of SIM using bioinformatics.METHODS: The GSE13205 was obtained from the Gene Expression Omnibus (GEO) database, including 13 SIM samples and 8 healthy samples, and the differentially expressed genes (DEGs) were identified by limma package in R language. Simultaneously, we searched for the genes related to oxidative stress in the Gene Ontology (GO) database. The intersection of the genes selected from the GO database and the genes from the GSE13205 was considered as OS-genes of SIM, where the differential genes were regarded as OS-DEGs. OS-DEGs were analyzed using GO enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and protein-protein interaction (PPI) networks. Hub genes in OS-DEGs were selected based on degree, and diagnostic genes were further screened by gene expression and receiver operating characteristic (ROC) curve. Finally, a miRNA-gene network of diagnostic genes was constructed.RESULTS: A total of 1089 DEGs were screened from the GSE13205, and 453 OS-genes were identified from the GO database. The overlapping DEGs and OS-genes constituted 25 OS-DEGs, including 15 significantly upregulated and 10 significantly downregulated genes. The top 10 hub genes, including CD36, GPX3, NQO1, GSR, TP53, IDH1, BCL2, HMOX1, JAK2, and FOXO1, were screened. Furthermore, 5 diagnostic genes were identified: CD36, GPX3, NQO1, GSR, and TP53. The ROC analysis showed that the respective area under the curves (AUCs) of CD36, GPX3, NQO1, GSR, and TP53 were 0.990, 0.981, 0.971, 0.971, and 0.971, which meant these genes had very high diagnostic values of SIM. Finally, based on these 5 diagnostic genes, we found that miR-124-3p and miR-16-5p may be potential targets for the treatment of SIM.CONCLUSIONS: The results of this study suggest that OS-genes might play an important role in SIM. CD36, GPX3, NQO1, GSR, and TP53 have potential as specific biomarkers for the diagnosis of SIM.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701300/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701300</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11062695/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11062695</a> | DOI:<a href=https://doi.org/10.1097/MD.0000000000037933>10.1097/MD.0000000000037933</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701300</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Ning Zhang</dc:creator>
<dc:creator>Dan Huang</dc:creator>
<dc:creator>Xiang Li</dc:creator>
<dc:creator>JinXia Yan</dc:creator>
<dc:creator>Qi Yan</dc:creator>
<dc:creator>WeiXing Ge</dc:creator>
<dc:creator>Jun Zhou</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Medicine</dc:source>
<dc:title>Identification and validation of oxidative stress-related genes in sepsis-induced myopathy</dc:title>
<dc:identifier>pmid:38701300</dc:identifier>
<dc:identifier>pmc:PMC11062695</dc:identifier>
<dc:identifier>doi:10.1097/MD.0000000000037933</dc:identifier>
</item>
<item>
<title>Acupuncture and moxibustion treatment for myasthenia gravis: A systematic review and meta-analysis</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701271/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: Acupuncture and moxibustion has a good effect on MG, which is better than conventional Western medicine in improving the total clinical effective rate and absolute clinical score.</description>
<content:encoded><![CDATA[<div>Medicine (Baltimore). 2024 May 3;103(18):e37961. doi: 10.1097/MD.0000000000037961.ABSTRACTBACKGROUND: Myasthenia gravis (MG) is a common autoimmune disease that often involves the skeletal muscle of the whole body and seriously affects patients' quality of life. Acupuncture and moxibustion treatment of MG has unique advantages, the aim is to evaluate the clinical effect of acupuncture and moxibustion on MG.METHODS: The literature on acupuncture and moxibustion treating MG in PubMed, CochraneLibrary, EMBASE, SCI, China Academic Journals full-text database, China Biology Medicine disc, VIP and Wanfang database were searched through computers from the establishment of the database to December 2022.RESULTS: A total of 11 studies were included, involving 658 patients, where 330 in the treatment group and 328 in the control group. The results of the meta-analysis showed that the treatment group performed better than the control group in improving the total clinical response rate (OR = 3.26, 95%[2.04,5.21], P < .01). Additionally, the treatment group outperformed the control group in raising the absolute clinical score (MD = -3.48, 95%CI[-5.17, -1.78], P < .01). However, there was no significant difference between the treatment group and the control group in improving the level of serum interleukin-6 receptor (MD = -1.45,95%CI[-6.85,3.95], P > .05) and OMG quantitative score (MD = -2.16,95%CI[-4.85,0.52], P > .05). The total clinical effective rate was tested for publication bias, which showed that the 2 sides of the funnel plot were asymmetrical, suggesting the possible existence of publication bias.CONCLUSION: Acupuncture and moxibustion has a good effect on MG, which is better than conventional Western medicine in improving the total clinical effective rate and absolute clinical score.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701271/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701271</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11062737/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11062737</a> | DOI:<a href=https://doi.org/10.1097/MD.0000000000037961>10.1097/MD.0000000000037961</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701271</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Ying Lu</dc:creator>
<dc:creator>Jian Li</dc:creator>
<dc:creator>Ting Yu</dc:creator>
<dc:creator>Chunlan Wu</dc:creator>
<dc:creator>Yi You</dc:creator>
<dc:creator>Changde Wang</dc:creator>
<dc:creator>Xiaoying Liu</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Medicine</dc:source>
<dc:title>Acupuncture and moxibustion treatment for myasthenia gravis: A systematic review and meta-analysis</dc:title>
<dc:identifier>pmid:38701271</dc:identifier>
<dc:identifier>pmc:PMC11062737</dc:identifier>
<dc:identifier>doi:10.1097/MD.0000000000037961</dc:identifier>
</item>
<item>
<title>Research hotspots and trends of complementary and alternative therapy for neuropathic pain: A bibliometric analysis</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701253/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: This study reveals the current status and hotspots of CAT for NP. The study also indicates that the effectiveness and effect mechanism of acupuncture or herbs for treating emotional problems caused by low back pain or postherpetic neuralgia may be a trend for future research.</description>
<content:encoded><![CDATA[<div>Medicine (Baltimore). 2024 May 3;103(18):e38054. doi: 10.1097/MD.0000000000038054.ABSTRACTBACKGROUND: Neuropathic pain (NP) is a common type of pain in clinic. Due to the limited effect of drug treatment, many patients with NP are still troubled by this disease. In recent years, complementary and alternative therapy (CAT) has shown good efficacy in the treatment of NP. As the interest in CAT for NP continues to grow, we conducted a bibliometric study of publications on CAT treatment for NP. The aim of this study is to analyze the development overview, research hotspots and future trends in the field of CAT and NP through bibliometric methodology, so as to provide a reference for subsequent researchers.METHODS: Publications on CAT in the treatment of NP from 2002 to 2022 were retrieved from the Web of Science Core Collection. Relevant countries, institutions, authors, journals, keywords, and references were analyzed bibliometrically using Microsoft Excel 2021, bibliometric platform, VOSviewer, and CiteSpace.RESULTS: A total of 898 articles from 46 countries were published in 324 journals, and they were contributed by 4455 authors from 1102 institutions. The most influential country and institution are China (n = 445) and Kyung Hee University (n = 63), respectively. Fang JQ (n = 27) and Evidence-Based Complementary and Alternative Medicine (n = 63) are the author and journal with the most publications in this field. The clinical efficacy, molecular biological mechanisms and safety of CAT for NP are currently hot directions. Low back pain, postherpetic neuralgia, acupuncture, and herbal are the hot topics in CAT and NP in recent years.CONCLUSION: This study reveals the current status and hotspots of CAT for NP. The study also indicates that the effectiveness and effect mechanism of acupuncture or herbs for treating emotional problems caused by low back pain or postherpetic neuralgia may be a trend for future research.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701253/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701253</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11062655/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11062655</a> | DOI:<a href=https://doi.org/10.1097/MD.0000000000038054>10.1097/MD.0000000000038054</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701253</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Shilin Wang</dc:creator>
<dc:creator>Yuanzheng Sun</dc:creator>
<dc:creator>Huixie Zhao</dc:creator>
<dc:creator>Yingying Li</dc:creator>
<dc:creator>Xiaoxin Wang</dc:creator>
<dc:creator>Qitong Zhang</dc:creator>
<dc:creator>Xiao-Jie Ren</dc:creator>
<dc:creator>Yong-Peng Mi</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Medicine</dc:source>
<dc:title>Research hotspots and trends of complementary and alternative therapy for neuropathic pain: A bibliometric analysis</dc:title>
<dc:identifier>pmid:38701253</dc:identifier>
<dc:identifier>pmc:PMC11062655</dc:identifier>
<dc:identifier>doi:10.1097/MD.0000000000038054</dc:identifier>
</item>
<item>
<title>The effect of massage on patients with chronic fatigue syndrome: A systematic review and meta-analysis</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701244/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: Our research findings suggest that massage therapy has a significant therapeutic effect on CFS, avoiding adverse reactions and improving fatigue symptoms. Therefore, massage therapy for chronic fatigue syndrome should be further promoted and applied.</description>
<content:encoded><![CDATA[<div>Medicine (Baltimore). 2024 May 3;103(18):e37973. doi: 10.1097/MD.0000000000037973.ABSTRACTBACKGROUND: Chronic fatigue syndrome (CFS) is a long-term and complex chronic disease that seriously affects the physical and mental health and quality of life of patients. Massage, as one of the methods in traditional Chinese medicine, can treat both symptoms and root causes and is widely used to treat CFS. The main purpose is to systematically evaluate the impact of massage therapy on the efficacy and safety of CFS patients, providing a reference for clinical practice.METHODS: By searching for literature published in PubMed, Cochrane Library, Web of Science, Embase, Wanfang Database, VIP Database, and China National Knowledge Infrastructure Database until November 2023, randomized controlled trial studies were selected according to the established inclusion and exclusion criteria. The Cochrane system evaluation manual was used to evaluate the quality of the included studies, and RevMan5.4 software was used for meta-analysis.RESULTS: 32 randomized controlled trials were included, with a total of 2594 CFS patients. Meta-analysis showed that the total score of the fatigue scale (FS-14) in the treatment group, MD = -1.59, 95% CI (-1.84, -1.34), P < .00001; Physical fatigue score, MD = -1.30, 95% CI (-1.60, -1.00), P < .00001; Mental fatigue score, MD = -0.84, 95% CI (-0.99, -0.72), P < .0001]; Effective rate [RR = 1.23, 95% CI (1.19,1.28), P < .00001]; all indicators were superior to the control group, Only one study reported adverse reactions, including local swelling, skin bruising, and nausea.CONCLUSION: Our research findings suggest that massage therapy has a significant therapeutic effect on CFS, avoiding adverse reactions and improving fatigue symptoms. Therefore, massage therapy for chronic fatigue syndrome should be further promoted and applied.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701244/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701244</a> | PMC:<a href="https://www.ncbi.nlm.nih.gov/pmc/PMC11062744/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">PMC11062744</a> | DOI:<a href=https://doi.org/10.1097/MD.0000000000037973>10.1097/MD.0000000000037973</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701244</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Jingnan Li</dc:creator>
<dc:creator>Feng Piao</dc:creator>
<dc:creator>Qiaoqiao Zeng</dc:creator>
<dc:creator>Huixin Yan</dc:creator>
<dc:creator>Yunpeng Bi</dc:creator>
<dc:creator>Shaobo Zhang</dc:creator>
<dc:creator>Bailin Song</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Medicine</dc:source>
<dc:title>The effect of massage on patients with chronic fatigue syndrome: A systematic review and meta-analysis</dc:title>
<dc:identifier>pmid:38701244</dc:identifier>
<dc:identifier>pmc:PMC11062744</dc:identifier>
<dc:identifier>doi:10.1097/MD.0000000000037973</dc:identifier>
</item>
<item>
<title>Assessing the Swallowing Function in Children with Spinal Muscular Atrophy: An Easily Accessible and Objective Multidimensional Approach</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701158/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSIONS: Both tools provided new insights on the oral and pharyngeal phase of swallowing in SMA patients. In SMA patients, muscle strength in certain crucial anatomical regions during swallowing is weaker than in healthy children.</description>
<content:encoded><![CDATA[<div>J Neuromuscul Dis. 2024 May 2. doi: 10.3233/JND-240017. Online ahead of print.ABSTRACTBACKGROUND: Spinal muscular atrophy (SMA), a genetic neuromuscular disease caused by lack of survival of motor neuron (SMN) protein, is characterized by muscular atrophy and respiratory and bulbar dysfunction. While swallowing disorders are common, they remain poorly studied.OBJECTIVES: Our study aimed to explore 1) intraoral pressure measurements with the Iowa Oral Performance Instrument system and the reliability of a Swallowing Function Assessment Questionnaire (SFAQ) in healthy controls, and 2) evaluate their use as swallowing function biomarkers and the evolution of swallowing function over time in children with SMA.METHODS: We recruited 53 healthy children and 27 SMA patients all treated with SMN gene modulator therapy. Participants completed the SFAQ and underwent at least one measurement of maximal oral pressures (lingual, labial, and masseter).RESULTS: Mean oral normalized pressure index were lower (all sites p < 0.001) and mean SFAQ scores were higher (p < 0.001) in patients compared with healthy controls. Pressure evolution over 1 year in SMA patients for all three oral sites did not show significant differences. SFAQ scores correlated negatively with oral pressures at all three sites in patients.CONCLUSIONS: Both tools provided new insights on the oral and pharyngeal phase of swallowing in SMA patients. In SMA patients, muscle strength in certain crucial anatomical regions during swallowing is weaker than in healthy children.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701158/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701158</a> | DOI:<a href=https://doi.org/10.3233/JND-240017>10.3233/JND-240017</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701158</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Charlotte Colot</dc:creator>
<dc:creator>Sarah Benmechri</dc:creator>
<dc:creator>Elke Everaert</dc:creator>
<dc:creator>Sarah Muys</dc:creator>
<dc:creator>Linde Van Himme</dc:creator>
<dc:creator>Valentine Tahon</dc:creator>
<dc:creator>Maurine Salmon</dc:creator>
<dc:creator>Dorine Van Dyck</dc:creator>
<dc:creator>Elke De Vos</dc:creator>
<dc:creator>Nicolas Deconinck</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Journal of neuromuscular diseases</dc:source>
<dc:title>Assessing the Swallowing Function in Children with Spinal Muscular Atrophy: An Easily Accessible and Objective Multidimensional Approach</dc:title>
<dc:identifier>pmid:38701158</dc:identifier>
<dc:identifier>doi:10.3233/JND-240017</dc:identifier>
</item>
<item>
<title>IMPatienT: An Integrated Web Application to Digitize, Process and Explore Multimodal PATIENt daTa</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38701156/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>Medical acts, such as imaging, lead to the production of various medical text reports that describe the relevant findings. This induces multimodality in patient data by combining image data with free-text and consequently, multimodal data have become central to drive research and improve diagnoses. However, the exploitation of patient data is problematic as the ecosystem of analysis tools is fragmented according to the type of data (images, text, genetics), the task (processing, exploration) and...</description>
<content:encoded><![CDATA[<div>J Neuromuscul Dis. 2024 Apr 29. doi: 10.3233/JND-230085. Online ahead of print.ABSTRACTMedical acts, such as imaging, lead to the production of various medical text reports that describe the relevant findings. This induces multimodality in patient data by combining image data with free-text and consequently, multimodal data have become central to drive research and improve diagnoses. However, the exploitation of patient data is problematic as the ecosystem of analysis tools is fragmented according to the type of data (images, text, genetics), the task (processing, exploration) and domain of interest (clinical phenotype, histology). To address the challenges, we developed IMPatienT (Integrated digital Multimodal PATIENt daTa), a simple, flexible and open-source web application to digitize, process and explore multimodal patient data. IMPatienT has a modular architecture allowing to: (i) create a standard vocabulary for a domain, (ii) digitize and process free-text data, (iii) annotate images and perform image segmentation, (iv) generate a visualization dashboard and provide diagnosis decision support. To demonstrate the advantages of IMPatienT, we present a use case on a corpus of 40 simulated muscle biopsy reports of congenital myopathy patients. As IMPatienT provides users with the ability to design their own vocabulary, it can be adapted to any research domain and can be used as a patient registry for exploratory data analysis. A demo instance of the application is available at https://impatient.lbgi.fr/.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38701156/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38701156</a> | DOI:<a href=https://doi.org/10.3233/JND-230085>10.3233/JND-230085</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38701156</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Corentin Meyer</dc:creator>
<dc:creator>Norma Beatriz Romero</dc:creator>
<dc:creator>Teresinha Evangelista</dc:creator>
<dc:creator>Brunot Cadot</dc:creator>
<dc:creator>Jocelyn Laporte</dc:creator>
<dc:creator>Anne Jeannin-Girardon</dc:creator>
<dc:creator>Pierre Collet</dc:creator>
<dc:creator>Ali Ayadi</dc:creator>
<dc:creator>Kirsley Chennen</dc:creator>
<dc:creator>Olivier Poch</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Journal of neuromuscular diseases</dc:source>
<dc:title>IMPatienT: An Integrated Web Application to Digitize, Process and Explore Multimodal PATIENt daTa</dc:title>
<dc:identifier>pmid:38701156</dc:identifier>
<dc:identifier>doi:10.3233/JND-230085</dc:identifier>
</item>
<item>
<title>Long COVID: lights and shadows on the clinical characterization of this emerging pathology</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38700879/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>More than 800 million individuals have contracted SARSCOV2 infection worldwide. It was estimated that almost 10-20% of these might suffer from Long COVID. It is a multisystemic syndrome, which negatively affects the quality of life with a significant burden of health loss compared to COVID negative individuals. Moreover, the risk of sequelae still remains high at 2 years in both nonhospitalized and hospitalized individuals. This review summarizes studies regarding long COVID and clarifies the...</description>
<content:encoded><![CDATA[<div>New Microbiol. 2024 May;47(1):15-27.ABSTRACTMore than 800 million individuals have contracted SARSCOV2 infection worldwide. It was estimated that almost 10-20% of these might suffer from Long COVID. It is a multisystemic syndrome, which negatively affects the quality of life with a significant burden of health loss compared to COVID negative individuals. Moreover, the risk of sequelae still remains high at 2 years in both nonhospitalized and hospitalized individuals. This review summarizes studies regarding long COVID and clarifies the definitions, the risk factors and the management of this syndrome. Finally, it delves into the most frequent long-term outcomes, especially postural orthostatic tachycardia syndrome" (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), brain fog, and their therapeutical possibilities.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38700879/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38700879</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38700879</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Viola Cogliandro</dc:creator>
<dc:creator>Paolo Bonfanti</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>The new microbiologica</dc:source>
<dc:title>Long COVID: lights and shadows on the clinical characterization of this emerging pathology</dc:title>
<dc:identifier>pmid:38700879</dc:identifier>
</item>
<item>
<title>Comparison of Guillain-Barre Syndrome Cases during and Prior to the COVID-19 Pandemic: A Multicentric Study</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38700304/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>BACKGROUND: Guillain-Barre syndrome (GBS) is one of the most common neurological manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Although data for a strong causal association is lacking, anecdotal reports, case series and systematic reviews linking the two have emerged in the literature. This prompted us to compare the clinical features, electrophysiology, and outcomes of GBS cases presenting during the pandemic with cases reported during a...</description>
<content:encoded><![CDATA[<div>J Assoc Physicians India. 2023 Sep;71(9):69-71. doi: 10.59556/japi.71.0317.ABSTRACTBACKGROUND: Guillain-Barre syndrome (GBS) is one of the most common neurological manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Although data for a strong causal association is lacking, anecdotal reports, case series and systematic reviews linking the two have emerged in the literature. This prompted us to compare the clinical features, electrophysiology, and outcomes of GBS cases presenting during the pandemic with cases reported during a similar time period prior to the pandemic.MATERIALS AND METHODS: Prospective data of GBS cases diagnosed as per the National Institute of Neurological Disorders and Stroke (NINDS) criteria was collected for a 6-month period (July-December 2021) at three tertiary care teaching hospitals during the coronavirus pandemic and compared with retrospective records-based data of cases prior to the pandemic (January-July 2019).RESULTS: A total of 40 cases were included in the cases, out of which 17 were in the prepandemic and 23 in the postpandemic period. A total of three cases temporally related to coronavirus disease 2019 (COVID-19) infection and four cases following COVID-19 vaccination were seen in the pandemic cohort. The clinical features, electrophysiological features, and outcomes were comparable during both periods. A slightly higher rate of in-hospital complications and single mortality was reported in the postpandemic period.DISCUSSION: The number of GBS hospital admissions, clinical presentation, electrodiagnostic features, and short-term outcomes did not differ significantly between the prepandemic and postpandemic periods; a slightly higher incidence of in-hospital complications was observed during the pandemic period. How to cite this article: Panicker P, R D, V AG, et al. Comparison of Guillain-Barre Syndrome Cases during and Prior to the COVID-19 Pandemic: A Multicentric Study. J Assoc Physicians India 2023;71(9):69-71.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38700304/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38700304</a> | DOI:<a href=https://doi.org/10.59556/japi.71.0317>10.59556/japi.71.0317</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38700304</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Praveen Panicker</dc:creator>
<dc:creator>Dileep R</dc:creator>
<dc:creator>Abdul V Gafoor</dc:creator>
<dc:creator>Prasanth S R</dc:creator>
<dc:creator>Thomas Iype</dc:creator>
<dc:creator>James Jose</dc:creator>
<dc:creator>Antony Stanley</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>The Journal of the Association of Physicians of India</dc:source>
<dc:title>Comparison of Guillain-Barre Syndrome Cases during and Prior to the COVID-19 Pandemic: A Multicentric Study</dc:title>
<dc:identifier>pmid:38700304</dc:identifier>
<dc:identifier>doi:10.59556/japi.71.0317</dc:identifier>
</item>
<item>
<title>POLR3A-related disorders: From spastic ataxia to generalised dystonia and long-term efficacy of deep brain stimulation</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38700104/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>While biallelic POLR3A loss-of-function variants are traditionally linked to hypomyelinating leukodystrophy, patients with a specific splice variant c.1909+22G>A manifest as adolescent-onset spastic ataxia without overt leukodystrophy. In this study, we reported eight new cases, POLR3A-related disorder with c.1909+22 variant. One of these patients showed expanded phenotypic spectrum of generalised dystonia and her sister remained asymptomatic except for hypodontia. Two patients with dystonic arm...</description>
<content:encoded><![CDATA[<div>Ann Clin Transl Neurol. 2024 May 3. doi: 10.1002/acn3.52064. Online ahead of print.ABSTRACTWhile biallelic POLR3A loss-of-function variants are traditionally linked to hypomyelinating leukodystrophy, patients with a specific splice variant c.1909+22G>A manifest as adolescent-onset spastic ataxia without overt leukodystrophy. In this study, we reported eight new cases, POLR3A-related disorder with c.1909+22 variant. One of these patients showed expanded phenotypic spectrum of generalised dystonia and her sister remained asymptomatic except for hypodontia. Two patients with dystonic arm tremor responded to deep brain stimulation. In our systemic literature review, we found that POLR3A-related disorder with c.1909+22 variant has attenuated disease severity but frequency of dystonia and upper limb tremor did not differ among genotypes.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38700104/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38700104</a> | DOI:<a href=https://doi.org/10.1002/acn3.52064>10.1002/acn3.52064</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38700104</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Wai Yan Yau</dc:creator>
<dc:creator>Catherine Ashton</dc:creator>
<dc:creator>Eoin Mulroy</dc:creator>
<dc:creator>Thomas Foltynie</dc:creator>
<dc:creator>Patricia Limousin</dc:creator>
<dc:creator>Jana Vandrovcova</dc:creator>
<dc:creator>Kunal P Verma</dc:creator>
<dc:creator>Rick Stell</dc:creator>
<dc:creator>Mark Davis</dc:creator>
<dc:creator>Phillipa Lamont</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Annals of clinical and translational neurology</dc:source>
<dc:title>POLR3A-related disorders: From spastic ataxia to generalised dystonia and long-term efficacy of deep brain stimulation</dc:title>
<dc:identifier>pmid:38700104</dc:identifier>
<dc:identifier>doi:10.1002/acn3.52064</dc:identifier>
</item>
<item>
<title>Effect of a graded running race on lower limb muscle damage, jump performance and muscle soreness in men and women</title>
<link>https://pubmed.ncbi.nlm.nih.gov/38700004/?utm_source=Feedvalidator&utm_medium=rss&utm_campaign=None&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&fc=None&ff=20240507045652&v=2.18.0.post9+e462414</link>
<description>CONCLUSION: Structural and functional recovery was incomplete in both sexes up to D3-4, although DOMS had disappeared. More emphasis should be placed on hamstring muscle recovery. Highlighting the intermuscular compensations that can occur during multi-joint testing tasks, the structural-functional relationships were either positive or negative, muscle- and sex-dependent.</description>
<content:encoded><![CDATA[<div>Scand J Med Sci Sports. 2024 May;34(5):e14643. doi: 10.1111/sms.14643.ABSTRACTPURPOSE: Delayed structural and functional recovery after a 20 km graded running race was analyzed with respect to the sex effect.METHODS: Thirteen female and 14 male recreational runners completed the race and three test sessions: one before (PRE) and two after, once on Day 1 or 2 (D1-2) and then on Day 3 or 4 (D3-4). Muscle damage was assessed indirectly using ultrasonography to quantify changes in cross-sectional area (CSA) of 10 lower-limb muscles. Delayed onset of muscle soreness (DOMS) was assessed for three muscle groups. Functional recovery was quantified by kinetic analysis of a squat jump (SJ) and a drop jump (DJ) test performed on a sledge ergometer. Linear mixed models were used to assess control group reproducibility and recovery patterns according to sex.RESULTS: Regardless of sex, DOMS peaked at D1-2 for all muscle groups and resolved at D3-4. CSA was increased in each muscle group until D3-4, especially in the semimembranosus muscle. A specific increase was found in the short head of the biceps femoris in women. Regardless of sex, SJ and DJ performances declined up to D3-4. Depending on the muscle, positive and/or negative correlations were found between structural and functional changes. Some of these were sex-specific.CONCLUSION: Structural and functional recovery was incomplete in both sexes up to D3-4, although DOMS had disappeared. More emphasis should be placed on hamstring muscle recovery. Highlighting the intermuscular compensations that can occur during multi-joint testing tasks, the structural-functional relationships were either positive or negative, muscle- and sex-dependent.PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/38700004/?utm_source=Feedvalidator&utm_medium=rss&utm_content=1lIZdG7__acOiPmWIGFq09kRZNNr6-cdIuyHCdkoPZo0v8FMLk&ff=20240507045652&v=2.18.0.post9+e462414">38700004</a> | DOI:<a href=https://doi.org/10.1111/sms.14643>10.1111/sms.14643</a></div>]]></content:encoded>
<guid isPermaLink="false">pubmed:38700004</guid>
<pubDate>Fri, 03 May 2024 06:00:00 -0400</pubDate>
<dc:creator>Robin Macchi</dc:creator>
<dc:creator>Yoko Kunimasa</dc:creator>
<dc:creator>Pascale Chavet</dc:creator>
<dc:creator>Baptiste Corcelle</dc:creator>
<dc:creator>Laura Pomportes</dc:creator>
<dc:creator>Camille Fazzari</dc:creator>
<dc:creator>Arnaud Hays</dc:creator>
<dc:creator>Fabrice Vercruyssen</dc:creator>
<dc:creator>Francesca Rossi</dc:creator>
<dc:creator>David Bendahan</dc:creator>
<dc:creator>Caroline Nicol</dc:creator>
<dc:date>2024-05-03</dc:date>
<dc:source>Scandinavian journal of medicine & science in sports</dc:source>
<dc:title>Effect of a graded running race on lower limb muscle damage, jump performance and muscle soreness in men and women</dc:title>
<dc:identifier>pmid:38700004</dc:identifier>
<dc:identifier>doi:10.1111/sms.14643</dc:identifier>
</item>
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